Effectiveness of Cardiac Resynchronization Therapy in Patients with Cardiac Sarcoidosis

Effectiveness of Cardiac Resynchronization Therapy in Patients with Cardiac Sarcoidosis | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 11 June 2025 V1 Latest version Share on Effectiveness of Cardiac Resynchronization Therapy in Patients with Cardiac Sarcoidosis Authors : Maryam M. Sani 0009-0001-5480-8430 [email protected] , James Flynn , Ashkan Abdollahi , Chloe Duvall , Jana Lovell , Michelle Sharp , Edward Chen 0000-0003-0723-8209 , Nisha Gilotra , and Jonathan Chrispin 0000-0002-7985-3019 Authors Info & Affiliations https://doi.org/10.22541/au.174967397.78323725/v1 185 views 99 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objectives: To evaluate the clinical outcomes of patients with cardiac sarcoidosis (CS) undergoing cardiac resynchronization therapy (CRT) among a cohort of patients with CS and cardiac implantable electronic devices. Background: CS manifests with conduction abnormalities, ventricular arrhythmias (VA), and heart failure (HF). While CRT improves outcomes in select nonischemic cardiomyopathies, its specific role in CS-related cardiomyopathy remains unclear. Methods: This retrospective cohort study included patients from the Johns Hopkins Cardiac Sarcoidosis Program (2004–2024) with a clinical or histological CS diagnosis who underwent ICD or pacemaker implantation, with or without CRT. Outcomes assessed included HF hospitalizations, appropriate anti-tachycardia pacing (ATP) or ICD shocks, heart transplantation, all-cause mortality, and a composite of these measures. Results: Among 212 patients (40.1% female, mean age 52.8 ± 11.1 years), 85 received CRT (82 CRT-D, 3 CRT-P). CRT recipients had significantly lower baseline left ventricular ejection fraction (LVEF) than non-CRT patients (mean difference: 11%; P < .01) but demonstrated greater LVEF improvement over time (1.43%; P = .03). During a follow-up of 6.15 ± 4.43 years, HF hospitalizations occurred in 12.7%, ATP/ICD shocks in 40.6%, and death in 8.0%. Composite outcomes occurred in 48.5% with no significant differences between CRT and non-CRT groups ( P = .50). CRT patients had lower freedom from HF hospitalizations ( P = .01) but similar arrhythmia treatment rates ( P = .70). Conclusions: CRT in CS was associated with improved LVEF but higher HF hospitalization rates and comparable VA treatment outcomes. These findings highlight the need for further research to optimize CRT utilization in this population. Supplementary Material File (effectiveness of crt in patients with cs.docx) Download 1.09 MB Information & Authors Information Version history V1 Version 1 11 June 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords clinical: electrophysiology – cardiac arrest/sudden death clinical: electrophysiology – ventricular tachycardia clinical: implantable devices – biventricular pacing/defibrillation Authors Affiliations Maryam M. Sani 0009-0001-5480-8430 [email protected] Johns Hopkins Medicine Division of Cardiology View all articles by this author James Flynn Johns Hopkins Medicine Division of Cardiology View all articles by this author Ashkan Abdollahi Johns Hopkins Medicine Division of Cardiology View all articles by this author Chloe Duvall Johns Hopkins Medicine Division of Cardiology View all articles by this author Jana Lovell Johns Hopkins Medicine Division of Cardiology View all articles by this author Michelle Sharp Johns Hopkins University Department of Medicine View all articles by this author Edward Chen 0000-0003-0723-8209 Johns Hopkins University Department of Medicine View all articles by this author Nisha Gilotra Johns Hopkins Medicine Division of Cardiology View all articles by this author Jonathan Chrispin 0000-0002-7985-3019 Johns Hopkins Medicine Division of Cardiology View all articles by this author Metrics & Citations Metrics Article Usage 185 views 99 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Maryam M. Sani, James Flynn, Ashkan Abdollahi, et al. Effectiveness of Cardiac Resynchronization Therapy in Patients with Cardiac Sarcoidosis. Authorea . 11 June 2025. DOI: https://doi.org/10.22541/au.174967397.78323725/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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