Perceived social support and coping style as mediators between resilience and health-related Quality of Life in women newly diagnosed with breast cancer: A cross-sectional study

Perceived social support and coping style as mediators between resilience and health-related Quality of Life in women newly diagnosed with breast cancer: A cross-sectional study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Perceived social support and coping style as mediators between resilience and health-related Quality of Life in women newly diagnosed with breast cancer: A cross-sectional study Kaina Zhou, Lulu Li, Wenqian Zhao, Xue Bai, Mengyue Zhang, Dongfang Han, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-42009/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Background: Breast cancer may impair health-related quality of life (HRQoL). We examined the mediating roles of perceived social support (PSS) and coping style (CS) in the relationship between resilience and HRQoL in newly diagnosed breast cancer patients. Methods: Four-hundred thirty-one patients completed a survey at two hospitals in Shaanxi Province, China, using self-report measures assessing HRQoL, resilience, PSS, and CS. A one-sample t-test analyzed differences between resilience, PSS, and CS in breast cancer patients and the corresponding norm. Multivariate linear regression analyzed the independent predictors of HRQoL. The mediating roles of PSS and CS between resilience and HRQoL were investigated using structural equation modeling (SEM). Results: Participants had significantly lower scores for resilience and PSS and higher scores for the avoidance and resignation CSs than their corresponding norm. SEM analysis showed resilience had significant direct effects on PSS (B = 0.59, 95% CI [0.49, 0.68], P = 0.003), CS (confrontation: B = 0.53, 95% CI [0.44, 0.62], P = 0.001; resignation: B = -0.66, 95% CI [-0.74, -0.57], P = 0.002), and HRQoL (B range from 0.54–0.58). Resilience had significant indirect effects (B range from 0.09–0.27), and PSS and CS had significant direct effects on HRQoL (P < 0.05). Conclusions: Newly diagnosed breast cancer patients had lower resilience and PSS and higher negative CSs. PSS and CS appeared to mediate the influence of resilience on HRQoL. Multimodal intervention programs focusing on PSS and CS might increase the influence of resilience on HRQoL in breast cancer patients. Health Economics & Outcomes Research Oncology breast cancer resilience perceived social support coping style health-related quality of life Figures Figure 1 Figure 2 Background As a major stressful life event, breast cancer diagnosis and treatment-related adverse effects could cause severe physical and psychological trauma to the patient, and eventually, result in damage to their health-related quality of life (HRQoL) [1, 2]. The improvement of breast cancer treatment strategies and an increased survival rate has made the psychosocial rehabilitation of patients increasingly important [3]. Resilience refers to an individual’s ability to adapt and successfully cope with adversity [4]. This ability changes continuously with the interactions between the individual and the environment [4–6]. Resilience levels integrate physiological, psychological, and social functions that affect an individual’s HRQoL after suffering from stressful events [7]. Women with breast cancer experience different degrees of psychological trauma during the process of diagnosis, treatment, and rehabilitation [5, 8, 9]. However, previous studies have focused primarily on negative psychological and behavioral responses such as anxiety and depression [8, 9], fear of progression/relapse [10, 11], decreased self-efficacy [12], poor perception of social support [13, 14], and negative coping strategies [15]. Few studies have examined the direct and indirect effects of resilience on the physical, psychological, and social functioning of women with breast cancer [7, 16, 17], and studies of women who have been newly diagnosed are even more limited. HRQoL is an individual’s self-perception of their physical, psychological, and social functioning [18]. It is an essential indicator for evaluating the overall therapeutic effect of cancer treatment and the overall functional rehabilitation of patients during their lifetime [18]. Diseases and various negative stressors affect the HRQoL of breast cancer patients with varying degrees, especially in the field of psychosocial functioning [18]. Commonly reported factors that influence HRQoL include anxiety, depression, and despair [8, 9]; perceived social support (PSS) [13, 14]; and coping style (CS) [15]. Social support and CS are also important mediator variables of HRQoL [19, 20]. However, there is a lack of research evidence on how PSS and CS mediate the relationship between resilience and HRQoL in women newly diagnosed with breast cancer. Theoretical basis This study is based on the Neuman Systems Model (NSM), a theoretical framework for nursing that emphasizes the interaction between people and the environment, and the individual’s response to stressors in the environment. The main components of this model include the stressor, the body’s defense, and nursing interventions. When a stressor acts on the body, the body reacts defensively, and the purpose of a nursing intervention is to maintain and restore the balance of the body’s system [21]. Each woman with breast cancer is an independent system; the disease and its treatment-related factors (stressors) will have various negative effects on the patient (system), and then cause changes in their psychological toughness (body defense). Through comprehensive consideration of the positive role of the patient’s self-defense capabilities and the positive guiding effects of a patient’s personal responses (i.e., CS and PSS), this study used the NSM as the theoretical basis to build an influencing factor model. Resilience was regarded as the body’s defense, PSS and CS as the personal responses, and HRQoL as the patient-reported outcome (Figure 1). This model was used to examine the mediator roles of PSS and CS (i.e., mediator variables) in the relationship between resilience (i.e., independent variable) and HRQoL (i.e., outcome variable). To our knowledge, only one study has used the NSM as the theoretical basis for breast cancer patient research on nausea and vomiting caused by chemotherapy [22]. It has not been reported as the theoretical basis in research examining HRQoL in breast cancer patients. [Figure 1 near here] The purpose of the study is to examine the mediator roles of PSS and CS in the relationship between resilience and HRQoL in women newly diagnosed with breast cancer. There are two hypotheses: (i) resilience, PSS, and CS are independent predictors of HRQoL; and (ii) PSS and CS mediate the relationship between resilience and HRQoL. The study’s findings will provide new evidence for identifying the mediator roles of psychosocial factors in the relationship between resilience and HRQoL, and for developing multimodal intervention programs to improve HRQoL in women newly diagnosed with breast cancer. Methods Design, participants, and sampling We used a cross-sectional study design. Convenience sampling was used to recruit women with breast cancer who had been admitted to the Tumor Hospital of Shaanxi Province or the First Affiliated Hospital of Xi’an Jiaotong University. Inclusion criteria were women newly diagnosed with breast cancer, aged 18 years or older, and Chinese speakers. The exclusion criteria were patients with other comorbid non-breast tumors, breast diseases, or cognitive disorders (screened by a blinded psychiatrist according to the criteria of the DSM-5.). The required sample size was estimated based on the metric of 5 to 10 participants per item in a validated instrument [23] to ensure sufficient power. Considering that the largest instrument used has 36 items, the appropriate sample size should be 180 to 360 patients. Measurements We used four existing instruments to assess HRQoL, resilience, PSS, and CS. Functional Assessment of Cancer Therapy-Breast version 4.0 Patients’ HRQoL was measured by the 36-item Chinese Functional Assessment of Cancer Therapy–Breast version 4.0 (FACT-Bv4.0). Each item is rated on a 5-point Likert scale (0 = not at all, 4 = very much). The items are divided into five subscales (i.e., social/family well-being [SWB], physical well-being [PWB], functional well-being [FWB], emotional well-being [EWB], and breast cancer-specific [BCS] concerns) [24]. The FACT-Bv4.0 total score (ranging from 0 to 144) is the sum of the five subscales scores, with a higher score indicating better HRQoL [25]. A validation study of the Chinese FACT-Bv4.0 resulted in higher reliability (Cronbach’s a of the five subscales ranges from 0.59 to 0.85) and satisfactory validity [25]. In this study, the Cronbach’s a for the overall scale was 0.93 and, for each of the five subscales, it was 0.85 (PWB), 0.91 (SWB), 0.86 (EWB), 0.89 (FWB), and 0.70 (BCS). Connor–Davidson Resilience scale The 25-item Chinese Connor–Davidson Resilience Scale (CD-RISC) was used to measure psychological resilience. Responses are indicated on a 5-point Likert-type scale, ranging from 0 (not true at all) to 4 (true nearly all the time). Items are divided into three subscales—tenacity, self-reliance, and optimism. The total score ranges from 0 to 100, with a higher score reflecting higher resilience [26]. The Chinese CD-RISC also has high reliability (Cronbach’s a = 0.91) and satisfactory validity [26]. In this study, the Cronbach’s a values were 0.95 (CD-RISC), 0.92 (tenacity), 0.77 (self-reliance), and 0.88 (optimism). Multidimensional Scale of Perceived Social Support The 12-item Chinese Multidimensional Scale of Perceived Social Support (MSPSS) measures perceived support from family, friends, and significant others. Items are rated on a 7-point Likert scale (1 = very strongly disagree, 7 = very strongly agree). The total score is the sum of all items, ranging from 12 to 84, with a higher score indicating higher PSS [27]. The Chinese MSPSS has been well validated in university students (Cronbach’s a = 0.92) [28] and in patients with methadone maintenance treatment (Cronbach’s a = 0.92) [29]. In this study, the Cronbach’s a values were 0.93 (MSPSS), 0.91 (family support), 0.90 (friends support), and 0.93 (significant others support). Medical Coping Mode questionnaire The 20-item Chinese Medical Coping Mode questionnaire (MCMQ) was used to assess the CS of patients with breast cancer. It has three subscales, namely confrontation, avoidance, and resignation, with a higher subscale score indicating more confrontation, avoidance, or resignation, respectively [30]. The Chinese MCMQs have satisfactory psychometric properties (Cronbach’s a was 0.76) [30]. In this study, the Cronbach’s a for the three subscales were 0.70 (confrontation), 0.72 (avoidance), and 0.88 (resignation). Data collection and analysis Data were collected from March to December 2019. Patients were instructed to complete the questionnaires independently. If the patient had difficulties in reading or writing, a trained data collector read the items to the patient and recorded their responses. Categorical variables were summarized using frequencies and percentages, while continuous variables were summarized using mean and standard deviation (SD). A one-sample t -test was utilized to compare the total score of the CD-RISC and MSPSS, and the three subscales scores of the MCMQ with the corresponding normative data. A multivariate linear regression analysis was performed to identify the influence of resilience, PSS, and CS on HRQoL when controlling for socio-demographics and clinical characteristics. Structural equation modeling (SEM) was employed using the maximum likelihood bootstrapping method [30] to examine the mediating role of PSS and CS on the relationship between resilience and HRQoL. Standardized direct, indirect, and total effects, and R 2 with a corresponding 95% bias-corrected confidence interval were estimated based on 1 000 random samples (bootstrapping method subsample) generated by computer [31, 32]. The mediating roles were examined via three stages [33]: 1) significant direct effects of resilience (independent variable), PSS, and CS (mediators); 2) significant direct effects of resilience on HRQoL (outcome variable); and 3) significant indirect effects of resilience and direct effects of PSS and CS on HRQoL. The model fit was examined with c 2 value (desired significance P > 0.05), adjusted goodness-of-fit index (AGFI; desired value ³ 0.90), and root mean square error of approximation (RMSEA; desired value < 0.08) [32]. The data were analyzed using SPSS 25.0 and AMOS 21.0 (IBM Corp., Armonk, NY). A value of P < 0.05 (two-tailed) was considered statistically significant. Ethical statement The Human Research Ethics Committee of Xi’an Jiaotong University reviewed and approved the study protocol (2018-9800). Written informed consent was obtained from each patient before administering the questionnaire survey. Furthermore, the study conforms to the standards contained in the Declaration of Helsinki, as amended. Results A total of 440 patients met the eligibility criteria and 431 (98.0%) completed the questionnaires with no missing data; 127 (29.5%) were from the Tumor Hospital of Shaanxi Province, and 304 (70.5%) were from the First Affiliated Hospital of Xi’an Jiaotong University. Nine patients were excluded due to comorbid non-breast tumors ( n = 3), other breast disease ( n = 4), and refusal to provide written informed consent ( n = 2). Table 1 summarizes the socio-demographic, clinical characteristics, and results for the four questionnaires used in the data analysis of the sample. Table 2 shows the comparisons of resilience, social support, coping style, and corresponding norms. [Table 1 near here] [Table 2 near here] After controlling for the socio-demographic and clinical characteristics, resilience, PSS, and CS (i.e., confrontation, resignation) significantly influenced HRQoL, with R 2 of 0.64 (Model A), 0.64 (Model B), and 0.66 (Model C; P < 0.001; Table 3). [Table 3 near here] Figure 2 illustrates the SEM analysis that further showed resilience had significant direct effects on PSS, CS, and HRQoL; resilience had significant indirect effects ( B s ranged from 0.09 to 0.27. P < 0.01), and PSS and CS had significant direct effects on HRQoL ( P < 0.05). The model fit indices were all satisfied (Figure 2). [Figure 2 near here] Discussion After controlling for socio-demographic and clinical characteristics, statistical analyses demonstrated that women newly diagnosed with breast cancer had poor HRQoL, which was significantly influenced by resilience, PSS, and CS (confrontation and resignation). Additionally, PSS and CS (confrontation and resignation) mediated the relationship between resilience and HRQoL. Based on the NSM, we constructed three models to examine the mediator role of PSS and CS. The SEM analysis further identified the mediating roles of PSS and CS in the relationship between resilience and HRQoL. First, in the three SEM models, resilience had significant direct effects on PSS, CS (i.e., confrontation and resignation), and HRQoL. This supports the first and second stages of the mediator role analysis [33]. Second, resilience had significant indirect effects, and PSS and CS (confrontation and resignation) had significant direct effects on HRQoL, thus supporting the third stage of the mediator role analysis [33]. These findings support our second hypothesis that PSS and CS mediated the relationship between resilience and HRQoL. This indicates that higher PSS and the confrontation CS would strengthen the positive influence of resilience on HRQoL. Accordingly, interventions for improving PSS and enhancing the confrontation CS should be prioritized when developing HRQoL improvement programs. Previous studies have reported the mediating role of social support between resilience and HRQoL [34]. However, to the best of our knowledge, no previous studies have reported the mediating roles of CS, or PSS and CS in the relationship between resilience and HRQoL in similar samples of breast cancer patients [16, 35, 36]. Therefore, our findings provide new evidence for identifying the mediator roles of psychosocial factors in the relationship between resilience and HRQoL and for developing multimodal intervention programs that consider PSS and CS to improve the positive influences of resilience on HRQoL in women with newly diagnosed breast cancer. The results with regard to poor HRQoL showed that functional well-being had the lowest score among the five subscales. This demonstrates that newly diagnosed women with breast cancer had the most prominent decrease in functional health. The emotional, social/family, and physical well-being subscales were also affected negatively during the disease course. The findings were consistent with prior research [7, 18] that indicated breast cancer patients had difficulties with physical, psychological, and social functioning. Although the breast cancer-specific subscales for additional concerns had the highest scores among the five subscales, which is consistent with our previous studies [37, 38], more attention should be devoted to the lower health domain scores in physical, social/family, emotional, and functional well-being that might be the result of concerns about potential future surgery and adjuvant therapy in clinical care for newly diagnosed patients. The patients had lower resilience and PSS, and higher negative CSs (i.e., avoidance and resignation) than that of the corresponding norm. These findings were consistent with previous studies [5, 13–16]. Closer inspection of the CD-RISC, MSPSS, and MCMQ subscales suggests that some patients were tenacious, perceived strong family support, and selected confrontation as their CS while dealing with the disease. Strong family support may be beneficial to improve the patient’s resilience. Considering the significance of family networks in China, it is necessary to further focus on enhancing family resilience for the patients in breast cancer care [39, 40]. However, patients with lower optimism and higher negative CS (i.e., avoidance and resignation) scores are a concerning group. The aforementioned findings suggest that psychosocial interventions should focus on improving poor resilience and changing the negative CSs of women newly diagnosed with breast cancer [41–43]. The finding that resilience, PSS, and CS (i.e., confrontation and resignation) had significant influences on HRQoL is consistent with previous research [44–46], and partially supports our first hypothesis that psychosocial factors are independent predictors of HRQoL. However, the avoidance CS did not significantly influence HRQoL. This may be because newly diagnosed patients chose the confrontation CS to deal with their health problems, as the confrontation CS score is closer to that of the norm. Although it has been reported that negative CSs are negatively associated with HRQoL [47], the insignificant impacts of avoidance in women with newly diagnosed breast cancer in this study needs further examination. This study has some limitations. First, the self-reported data of HRQoL, resilience, PSS, and CS lack objectivity. Information on related behaviors and physical health changes are recommended in future work. Second, the relationships among the above variables were possibly inflated due to response bias. Third, this cross-sectional study design could not support causal relationships among variables. Thus, their relationship trajectories during the long-term rehabilitation process should be further explored in longitudinal studies. Fourth, the mediator role of PSS and CS was analyzed based on the NSM, thus, the results might be different without the NSM, which need to be further explored in future work. Finally, the study was conducted in Xi’an, thus limiting the generalization of the findings to all women newly diagnosed with breast cancer. A multicenter design is recommended to enhance generalizability. Conclusion The patients in our study had relatively poor HRQoL, lower resilience and PSS, and higher avoidance and resignation CSs. Resilience, PSS, and CS had significant direct effects on HRQoL, with PSS and CS mediating the influence of resilience on HRQoL. A multimodal intervention program focusing on PSS and CS needs to be developed to improve the positive influence of resilience on HRQoL in breast cancer patients. Abbreviations PSS - Perceived Social Support AGFI Adjusted Goodness-of-Fit Index BCS - Breast Cancer-Specific CD-RISC - Connor–Davidson Resilience Scale CS - Coping Style EWB - Emotional Well-Being FACT-Bv4.0 - Functional Assessment of Cancer Therapy–Breast version 4.0 FWB - Functional Well-Being HRQoL - Health-Related Quality of Life MCMQ - Medical Coping Mode questionnaire MSPSS - Multidimensional Scale of Perceived Social Support NSM - Neuman Systems Model PWB - Physical Well-Being RMSEA - Root Mean Square Error of Approximation SD - Standard Deviation SEM - Structural Equation Modeling SWB - Social Well-Being Declarations Ethics approval and consent to participate : The Human Research Ethics Committee of Xi’an Jiaotong University reviewed and approved the study protocol (2018-9800). Written informed consent was obtained from each patient before administering the questionnaire survey. Furthermore, the study conforms to the standards contained in the Declaration of Helsinki, as amended. Consent for publication : Not applicable. Availability of data and materials : The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Competing interests : The authors declare that they have no competing interests. Funding : The study was supported by China Postdoctoral Science Foundation (No. 2018M643678). The funding body had no role in the design of the study and collection, analysis, and interpretation of data or in writing the manuscript. Author Contributions : KZ and XL designed the study. LL, WZ, XB, MZ, and DH collected the data. KZ analyzed and interpreted the data, and prepared the manuscript draft. KZ and XL revised the manuscript. All authors read and approved the final manuscript. 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Clin Nurs Res. 2019;28(1):107–24. doi: 10.1177/1054773817714562 Toscano A, Blanchin M, Bourdon M, Bonnaud Antignac A, Sebille V. Longitudinal associations between coping strategies, locus of control and health-related quality of life in patients with breast cancer or melanoma. Qual Life Res. 2020;29(5):1271–9. doi: 10.1007/s11136-019-02401-8 Tables Table 1 . Participants’ socio-demographic, clinical characteristics, and summary results for the four questionnaires ( N = 431) Mean ± SD n (%) Socio-Demographic Characteristics Age (years; mean ± SD a ; range: 27–77) 48.26 ± 10.40 Education Level Primary & Below 90 (20.9) Secondary 278 (64.5) Tertiary 63 (14.6) Marital status Married 425 (98.6) Other Marital Status 6 (1.4) Has Children Yes 416 (96.5) No 15 (3.5) Employment Status Unemployed 170 (39.4) Retired 54 (12.5) Employed 207 (48.1) Average monthly income over the past 12 months (Chinese Yuan) 9000 15 (3.5) Place of Residence Urban 207 (48.0) Rural 224 (52.0) Chronic Disease (disease course > 6 months) Yes 28 (6.5) No 403 (93.5) Clinical Characteristics Illness Stage 0-I 134 (31.1) II 203 (47.1) III 66 (15.3) IV 28 (6.5) Metastasis No Metastasis 285 (66.1) Axillary 119 (27.6) Other Metastasis 27 (6.3) Surgical Style No Surgery 146 (33.9) Modified Radical Mastectomy 203 (47.1) Simple Mastectomy 60 (13.9) Breast Conservation 23 (5.3) Adjuvant Therapy Conventional Chemotherapy 381 (88.4) Neoadjuvant Chemotherapy 26 (6.0) Radio Therapy 151 (35.0) Endocrine Therapy 231 (53.6) Targeted Therapy 47 (10.9) HRQoL b Physical Well-Being 17.75 ± 4.91 Social/Family Well-Being 17.66 ± 5.95 Emotional Well-Being 14.29 ± 4.48 Functional Well-Being 13.24 ± 5.04 Breast-Cancer-Specific Subscales for additional concerns 24.81 ± 3.97 FACT-Bv4.0 c Total Score 87.74 ± 18.69 Resilience Tenacity 27.51 ± 8.19 Self-Reliance 16.84 ± 4.42 Optimism 10.37 ± 3.06 CD-RISC d Total Score 54.72 ± 14.71 Perceived Social Support Family support 24.16 ± 3.24 Friends support 20.76 ± 4.00 Significant others support 20.52 ± 4.17 MSPSS e total score 65.45 ± 9.40 Coping Style Confrontation 19.87 ± 3.73 Avoidance 16.70 ± 1.90 Resignation 9.57 ± 2.87 a SD: standard deviation b health-related quality of life c Functional Assessment of Cancer Therapy–Breast version 4.0 d Connor-Davidson Resilience scale e Multidimensional Scale of Perceived Social Support Table 2 . Comparisons of resilience, social support, coping styles, and corresponding norms ( N = 431) Score Mean ± SD Norm MD a 95% CI b P Resilience ( N = 560) e CD-RISC c Total Score 54.72 ± 14.71 65.4 ± 13.9 -10.68 -12.59, -8.77 <0.001 Perceived Social Support ( N = 1589) f MSPSS d total score 65.45 ± 9.40 68.91 ± 11.99 -3.46 -4.68, -2.24 <0.001 Coping Style ( N = 701) g Confrontation 19.87 ± 3.73 19.48 ± 3.81 0.39 -0.10, 0.87 0.12 Avoidance 16.70 ± 1.90 14.44 ± 2.97 2.25 2.01, 2.50 <0.001 Resignation 9.57 ± 2.87 8.81 ± 3.17 0.76 0.39, 1.13 <0.001 a mean difference b confidence interval c Connor-Davidson Resilience scale d Multidimensional Scale of Perceived Social Support e Adapted from: Ren Y, Zhou Y, Ma C, et al. Influence of psychological resilience on job satisfaction of nurses. Chin Nurs Res. 2014;28(1C): 293–4. f Adapted from: Wang Y, Liu C. The mediating effects of social support and coping style between nurses’ personality characteristics and mental health. Chin J Nurs Educ. 2019;16(7): 536–40. g Adapted from: Shen X, Jiang Q. Report on application of Chinese version of MCMQ in 701 patients. Chin J Behav Med Sci. 2000;9(1):18–20. Table 3 . Independent predictors of health-related quality of life ( N = 431) Independent Variables B (95% CI) d P Model A a Resilience 0.75 (0.59, 0.92) <0.001 Perceived Social Support 0.29 (0.06, 0.51) 0.014 Coping Style (Confrontation) 0.60 (0.01, 1.19) 0.046 Model B b Resilience 0.81 (0.66, 0.97) <0.001 Perceived Social Support 0.28 (0.05, 0.51) 0.016 Coping Style (Avoidance) 0.82 (-0.07, 1.71) 0.070 Model C c Resilience 0.64 (0.47, 0.81) <0.001 Perceived Social Support 0.22 (0.002, 0.45) 0.048 Coping Style (Resignation) -1.68 (-2.48, -0.89) <0.001 A multivariate linear regression analysis was performed after controlling for the following dummy variables: education level (ref. primary and below), marital status (ref. married), has children (ref. yes), employment status (ref. unemployed), average monthly income over the past 12 months (Chinese Yuan) (ref. <3000), place of residence (ref. urban), chronic disease (ref. yes), illness stage (ref. 0–I), metastasis (ref. no metastasis), surgical style (ref. no surgery), adjuvant therapy (ref. conventional chemotherapy), and continuous characteristics (age). a R = 0.80, R 2 = 0.64, F = 14.33, P < 0.001. b R = 0.80, R 2 = 0.64, F = 14.25, P < 0.001. c R = 0.81, R 2 = 0.66, F = 15.76, P < 0.001. d confidence interval Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Indirect effect: Model (a): B = 0.15, 95% CI [0.08, 0.23], P = 0.002; Model (b): B = 0.09, 95% CI [0.03, 0.15], P = 0.005; Model (c): B = 0.27, 95% CI [0.19, 0.36], P = 0.002. Total effect of each of the three models: B = 0.72, 95% CI [0.65, 0.78], P = 0.002. (AGFI: adjusted goodness-of-fit index; reference value: 0.90. df: degree of freedom. RMSEA: root mean square error of approximation; reference value: \u003c0.08. 2 value (desired significance P \u003e 0.05). 95% CI: 95% confidence interval. B: standardized regression weights.)","description":"","filename":"2.PNG","url":"https://assets-eu.researchsquare.com/files/rs-42009/v2/c096463987c579115fa6c932.PNG"},{"id":13607884,"identity":"113e95d4-2e3d-40df-b841-bb40644a56b7","added_by":"auto","created_at":"2021-09-17 06:13:56","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":453076,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-42009/v2/98940351-4a17-49ac-a799-ffcc8a319dd7.pdf"}],"financialInterests":"","formattedTitle":"Perceived social support and coping style as mediators between resilience and health-related Quality of Life in women newly diagnosed with breast cancer: A cross-sectional study","fulltext":[{"header":"Background","content":"\u003cp\u003eAs a major stressful life event, breast cancer diagnosis and treatment-related adverse effects could cause severe physical and psychological trauma to the patient, and eventually, result in damage to their health-related quality of life (HRQoL) [1, 2]. The improvement of breast cancer treatment strategies and an increased survival rate has made the psychosocial rehabilitation of patients increasingly important [3].\u003c/p\u003e\n\u003cp\u003eResilience refers to an individual\u0026rsquo;s ability to adapt and successfully cope with adversity [4]. This ability changes continuously with the interactions between the individual and the environment [4\u0026ndash;6]. Resilience levels integrate physiological, psychological, and social functions that affect an individual\u0026rsquo;s HRQoL after suffering from stressful events [7]. Women with breast cancer experience different degrees of psychological trauma during the process of diagnosis, treatment, and rehabilitation [5, 8, 9]. However, previous studies have focused primarily on negative psychological and behavioral responses such as anxiety and depression [8, 9], fear of progression/relapse [10, 11], decreased self-efficacy [12], poor perception of social support [13, 14], and negative coping strategies [15]. Few studies have examined the direct and indirect effects of resilience on the physical, psychological, and social functioning of women with breast cancer [7, 16, 17], and studies of women who have been newly diagnosed are even more limited.\u003c/p\u003e\n\u003cp\u003eHRQoL is an individual\u0026rsquo;s self-perception of their physical, psychological, and social functioning [18]. It is an essential indicator for evaluating the overall therapeutic effect of cancer treatment and the overall functional rehabilitation of patients during their lifetime [18]. Diseases and various negative stressors affect the HRQoL of breast cancer patients with varying degrees, especially in the field of psychosocial functioning [18]. Commonly reported factors that influence HRQoL include anxiety, depression, and despair [8, 9]; perceived social support (PSS) [13, 14]; and coping style (CS) [15]. Social support and CS are also important mediator variables of HRQoL [19, 20]. However, there is a lack of research evidence on how PSS and CS mediate the relationship between resilience and HRQoL in women newly diagnosed with breast cancer.\u003c/p\u003e\n\u003ch2\u003eTheoretical basis\u003c/h2\u003e\n\u003cp\u003eThis study is based on the Neuman Systems Model (NSM), a theoretical framework for nursing that emphasizes the interaction between people and the environment, and the individual\u0026rsquo;s response to stressors in the environment. The main components of this model include the stressor, the body\u0026rsquo;s defense, and nursing interventions. When a stressor acts on the body, the body reacts defensively, and the purpose of a nursing intervention is to maintain and restore the balance of the body\u0026rsquo;s system [21].\u003c/p\u003e\n\u003cp\u003eEach woman with breast cancer is an independent system; the disease and its treatment-related factors (stressors) will have various negative effects on the patient (system), and then cause changes in their psychological toughness (body defense). Through comprehensive consideration of the positive role of the patient\u0026rsquo;s self-defense capabilities and the positive guiding effects of a patient\u0026rsquo;s personal responses (i.e., CS and PSS), this study used the NSM as the theoretical basis to build an influencing factor model. Resilience was regarded as the body\u0026rsquo;s defense, PSS and CS as the personal responses, and HRQoL as the patient-reported outcome (Figure 1). This model was used to examine the mediator roles of PSS and CS (i.e., mediator variables) in the relationship between resilience (i.e., independent variable) and HRQoL (i.e., outcome variable). To our knowledge, only one study has used the NSM as the theoretical basis for breast cancer patient research on nausea and vomiting caused by chemotherapy [22]. It has not been reported as the theoretical basis in research examining HRQoL in breast cancer patients.\u003c/p\u003e\n\u003cp\u003e[Figure 1 near here]\u003c/p\u003e\n\u003cp\u003eThe purpose of the study is to examine the mediator roles of PSS and CS in the relationship between resilience and HRQoL in women newly diagnosed with breast cancer. There are two hypotheses: (i) resilience, PSS, and CS are independent predictors of HRQoL; and (ii) PSS and CS mediate the relationship between resilience and HRQoL. The study\u0026rsquo;s findings will provide new evidence for identifying the mediator roles of psychosocial factors in the relationship between resilience and HRQoL, and for developing multimodal intervention programs to improve HRQoL in women newly diagnosed with breast cancer.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003eDesign, participants, and sampling\u003c/p\u003e\n\u003cp\u003eWe used a cross-sectional study design. Convenience sampling was used to recruit women with breast cancer who had been admitted to the Tumor Hospital of Shaanxi Province or the First Affiliated Hospital of Xi\u0026rsquo;an Jiaotong University. Inclusion criteria were women newly diagnosed with breast cancer, aged 18 years or older, and Chinese speakers. The exclusion criteria were patients with other comorbid non-breast tumors, breast diseases, or cognitive disorders (screened by a blinded psychiatrist according to the criteria of the DSM-5.). The required sample size was estimated based on the metric of 5 to 10 participants per item in a validated instrument [23] to ensure sufficient power. Considering that the largest instrument used has 36 items, the appropriate sample size should be 180 to 360 patients.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMeasurements\u003c/p\u003e\n\u003cp\u003eWe used four existing instruments to assess HRQoL, resilience, PSS, and CS.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eFunctional Assessment of Cancer Therapy-Breast version 4.0\u003c/p\u003e\n\u003cp\u003ePatients\u0026rsquo; HRQoL was measured by the 36-item Chinese Functional Assessment of Cancer Therapy\u0026ndash;Breast version 4.0 (FACT-Bv4.0). Each item is rated on a 5-point Likert scale (0 = not at all, 4 = very much). The items are divided into five subscales (i.e., social/family well-being [SWB], physical well-being [PWB], functional well-being [FWB], emotional well-being [EWB], and breast cancer-specific [BCS] concerns) [24]. The FACT-Bv4.0 total score (ranging from 0 to 144) is the sum of the five subscales scores, with a higher score indicating better HRQoL [25]. A validation study of the Chinese FACT-Bv4.0 resulted in higher reliability (Cronbach\u0026rsquo;s a of the five subscales ranges from 0.59 to 0.85) and satisfactory validity [25]. In this study, the Cronbach\u0026rsquo;s a for the overall scale was 0.93 and, for each of the five subscales, it was 0.85 (PWB), 0.91 (SWB), 0.86 (EWB), 0.89 (FWB), and 0.70 (BCS).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eConnor\u0026ndash;Davidson Resilience scale\u003c/p\u003e\n\u003cp\u003eThe 25-item Chinese Connor\u0026ndash;Davidson Resilience Scale (CD-RISC) was used to measure psychological resilience. Responses are indicated on a 5-point Likert-type scale, ranging from 0 (not true at all) to 4 (true nearly all the time). Items are divided into three subscales\u0026mdash;tenacity, self-reliance, and optimism. The total score ranges from 0 to 100, with a higher score reflecting higher resilience [26]. The Chinese CD-RISC also has high reliability (Cronbach\u0026rsquo;s a = 0.91) and satisfactory validity [26]. In this study, the Cronbach\u0026rsquo;s a values were 0.95 (CD-RISC), 0.92 (tenacity), 0.77 (self-reliance), and 0.88 (optimism).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMultidimensional Scale of Perceived Social Support\u003c/p\u003e\n\u003cp\u003eThe 12-item Chinese Multidimensional Scale of Perceived Social Support (MSPSS) measures perceived support from family, friends, and significant others. Items are rated on a 7-point Likert scale (1 = very strongly disagree, 7 = very strongly agree). The total score is the sum of all items, ranging from 12 to 84, with a higher score indicating higher PSS [27]. The Chinese MSPSS has been well validated in university students (Cronbach\u0026rsquo;s a = 0.92) [28] and in patients with methadone maintenance treatment (Cronbach\u0026rsquo;s a = 0.92) [29]. In this study, the Cronbach\u0026rsquo;s a values were 0.93 (MSPSS), 0.91 (family support), 0.90 (friends support), and 0.93 (significant others support).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMedical Coping Mode questionnaire\u003c/p\u003e\n\u003cp\u003eThe 20-item Chinese Medical Coping Mode questionnaire (MCMQ) was used to assess the CS of patients with breast cancer. It has three subscales, namely confrontation, avoidance, and resignation, with a higher subscale score indicating more confrontation, avoidance, or resignation, respectively [30]. The Chinese MCMQs have satisfactory psychometric properties (Cronbach\u0026rsquo;s a was 0.76) [30]. In this study, the Cronbach\u0026rsquo;s a for the three subscales were 0.70 (confrontation), 0.72 (avoidance), and 0.88 (resignation).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eData collection and analysis\u003c/p\u003e\n\u003cp\u003eData were collected from March to December 2019. Patients were instructed to complete the questionnaires independently. If the patient had difficulties in reading or writing, a trained data collector read the items to the patient and recorded their responses.\u003c/p\u003e\n\u003cp\u003eCategorical variables were summarized using frequencies and percentages, while continuous variables were summarized using mean and standard deviation (SD). A one-sample \u003cem\u003et\u003c/em\u003e-test was utilized to compare the total score of the CD-RISC and MSPSS, and the three subscales scores of the MCMQ with the corresponding normative data. A multivariate linear regression analysis was performed to identify the influence of resilience, PSS, and CS on HRQoL when controlling for socio-demographics and clinical characteristics.\u003c/p\u003e\n\u003cp\u003eStructural equation modeling (SEM) was employed using the maximum likelihood bootstrapping method [30] to examine the mediating role of PSS and CS on the relationship between resilience and HRQoL. Standardized direct, indirect, and total effects, and R\u003csup\u003e2\u003c/sup\u003e with a corresponding 95% bias-corrected confidence interval were estimated based on 1 000 random samples (bootstrapping method subsample) generated by computer [31, 32]. The mediating roles were examined via three stages [33]: 1) significant direct effects of resilience (independent variable), PSS, and CS (mediators); 2) significant direct effects of resilience on HRQoL (outcome variable); and 3) significant indirect effects of resilience and direct effects of PSS and CS on HRQoL. The model fit was examined with c\u003csup\u003e2\u003c/sup\u003e value (desired significance\u003cem\u003e P\u003c/em\u003e \u0026gt; 0.05), adjusted goodness-of-fit index (AGFI; desired value \u0026sup3; 0.90), and root mean square error of approximation (RMSEA; desired value \u0026lt; 0.08) [32]. The data were analyzed using SPSS 25.0 and AMOS 21.0 (IBM Corp., Armonk, NY). A value of \u003cem\u003eP\u003c/em\u003e \u0026lt; 0.05 (two-tailed) was considered statistically significant.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eEthical statement\u003c/p\u003e\n\u003cp\u003eThe Human Research Ethics Committee of Xi\u0026rsquo;an Jiaotong University reviewed and approved the study protocol (2018-9800). Written informed consent was obtained from each patient before administering the questionnaire survey. Furthermore, the study conforms to the standards contained in the Declaration of Helsinki, as amended.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eA total of 440 patients met the eligibility criteria and 431 (98.0%) completed the questionnaires with no missing data; 127 (29.5%) were from the Tumor Hospital of Shaanxi Province, and 304 (70.5%) were from the First Affiliated Hospital of Xi\u0026rsquo;an Jiaotong University. Nine patients were excluded due to comorbid non-breast tumors (\u003cem\u003en\u003c/em\u003e = 3), other breast disease (\u003cem\u003en\u003c/em\u003e = 4), and refusal to provide written informed consent (\u003cem\u003en\u003c/em\u003e = 2). Table 1 summarizes the socio-demographic, clinical characteristics, and results for the four questionnaires used in the data analysis of the sample. Table 2 shows the comparisons of resilience, social support, coping style, and corresponding norms.\u003c/p\u003e\n\u003cp\u003e[Table 1 near here]\u003c/p\u003e\n\u003cp\u003e[Table 2 near here]\u003c/p\u003e\n\u003cp\u003eAfter controlling for the socio-demographic and clinical characteristics, resilience, PSS, and CS (i.e., confrontation, resignation) significantly influenced HRQoL, with \u003cem\u003eR\u003c/em\u003e\u003csup\u003e2\u003c/sup\u003e of 0.64 (Model A), 0.64 (Model B), and 0.66 (Model C; \u003cem\u003eP\u003c/em\u003e \u0026lt; 0.001; Table 3).\u003c/p\u003e\n\u003cp\u003e[Table 3 near here]\u003c/p\u003e\n\u003cp\u003eFigure 2 illustrates the SEM analysis that further showed resilience had significant direct effects on PSS, CS, and HRQoL; resilience had significant indirect effects (\u003cem\u003eB\u003c/em\u003es ranged from 0.09 to 0.27. \u003cem\u003eP\u003c/em\u003e \u0026lt; 0.01), and PSS and CS had significant direct effects on HRQoL (\u003cem\u003eP\u003c/em\u003e \u0026lt; 0.05). The model fit indices were all satisfied (Figure 2).\u003c/p\u003e\n\u003cp\u003e[Figure 2 near here]\u003c/p\u003e"},{"header":"Discussion ","content":"\u003cp\u003eAfter controlling for socio-demographic and clinical characteristics, statistical analyses demonstrated that women newly diagnosed with breast cancer had poor HRQoL, which was significantly influenced by resilience, PSS, and CS (confrontation and resignation). Additionally, PSS and CS (confrontation and resignation) mediated the relationship between resilience and HRQoL.\u003c/p\u003e\n\u003cp\u003eBased on the NSM, we constructed three models to examine the mediator role of PSS and CS. The SEM analysis further identified the mediating roles of PSS and CS in the relationship between resilience and HRQoL. First, in the three SEM models, resilience had significant direct effects on PSS, CS (i.e., confrontation and resignation), and HRQoL. This supports the first and second stages of the mediator role analysis [33]. Second, resilience had significant indirect effects, and PSS and CS (confrontation and resignation) had significant direct effects on HRQoL, thus supporting the third stage of the mediator role analysis [33]. These findings support our second hypothesis that PSS and CS mediated the relationship between resilience and HRQoL. This indicates that higher PSS and the confrontation CS would strengthen the positive influence of resilience on HRQoL. Accordingly, interventions for improving PSS and enhancing the confrontation CS should be prioritized when developing HRQoL improvement programs. Previous studies have reported the mediating role of social support between resilience and HRQoL [34]. However, to the best of our knowledge, no previous studies have reported the mediating roles of CS, or PSS and CS in the relationship between resilience and HRQoL in similar samples of breast cancer patients [16, 35, 36]. Therefore, our findings provide new evidence for identifying the mediator roles of psychosocial factors in the relationship between resilience and HRQoL and for developing multimodal intervention programs that consider PSS and CS to improve the positive influences of resilience on HRQoL in women with newly diagnosed breast cancer.\u003c/p\u003e\n\u003cp\u003eThe results with regard to poor HRQoL showed that functional well-being had the lowest score among the five subscales. This demonstrates that newly diagnosed women with breast cancer had the most prominent decrease in functional health. The emotional, social/family, and physical well-being subscales were also affected negatively during the disease course. The findings were consistent with prior research [7, 18] that indicated breast cancer patients had difficulties with physical, psychological, and social functioning.\u003c/p\u003e\n\u003cp\u003eAlthough the breast cancer-specific subscales for additional concerns had the highest scores among the five subscales, which is consistent with our previous studies [37, 38], more attention should be devoted to the lower health domain scores in physical, social/family, emotional, and functional well-being that might be the result of concerns about potential future surgery and adjuvant therapy in clinical care for newly diagnosed patients.\u003c/p\u003e\n\u003cp\u003eThe patients had lower resilience and PSS, and higher negative CSs (i.e., avoidance and resignation) than that of the corresponding norm. These findings were consistent with previous studies [5, 13\u0026ndash;16]. Closer inspection of the CD-RISC, MSPSS, and MCMQ subscales suggests that some patients were tenacious, perceived strong family support, and selected confrontation as their CS while dealing with the disease. Strong family support may be beneficial to improve the patient\u0026rsquo;s resilience. Considering the significance of family networks in China, it is necessary to further focus on enhancing family resilience for the patients in breast cancer care [39, 40]. However, patients with lower optimism and higher negative CS (i.e., avoidance and resignation) scores are a concerning group. The aforementioned findings suggest that psychosocial interventions should focus on improving poor resilience and changing the negative CSs of women newly diagnosed with breast cancer [41\u0026ndash;43].\u003c/p\u003e\n\u003cp\u003eThe finding that resilience, PSS, and CS (i.e., confrontation and resignation) had significant influences on HRQoL is consistent with previous research [44\u0026ndash;46], and partially supports our first hypothesis that psychosocial factors are independent predictors of HRQoL. However, the avoidance CS did not significantly influence HRQoL. This may be because newly diagnosed patients chose the confrontation CS to deal with their health problems, as the confrontation CS score is closer to that of the norm. Although it has been reported that negative CSs are negatively associated with HRQoL [47], the insignificant impacts of avoidance in women with newly diagnosed breast cancer in this study needs further examination.\u003c/p\u003e\n\u003cp\u003eThis study has some limitations. First, the self-reported data of HRQoL, resilience, PSS, and CS lack objectivity. Information on related behaviors and physical health changes are recommended in future work. Second, the relationships among the above variables were possibly inflated due to response bias. Third, this cross-sectional study design could not support causal relationships among variables. Thus, their relationship trajectories during the long-term rehabilitation process should be further explored in longitudinal studies. Fourth, the mediator role of PSS and CS was analyzed based on the NSM, thus, the results might be different without the NSM, which need to be further explored in future work. Finally, the study was conducted in Xi\u0026rsquo;an, thus limiting the generalization of the findings to all women newly diagnosed with breast cancer. A multicenter design is recommended to enhance generalizability.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThe patients in our study had relatively poor HRQoL, lower resilience and PSS, and higher avoidance and resignation CSs. Resilience, PSS, and CS had significant direct effects on HRQoL, with PSS and CS mediating the influence of resilience on HRQoL. A multimodal intervention program focusing on PSS and CS needs to be developed to improve the positive influence of resilience on HRQoL in breast cancer patients.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003ePSS - Perceived Social Support\u003c/p\u003e\n\u003cp\u003eAGFI Adjusted Goodness-of-Fit Index\u003c/p\u003e\n\u003cp\u003eBCS - Breast Cancer-Specific\u003c/p\u003e\n\u003cp\u003eCD-RISC - Connor\u0026ndash;Davidson Resilience Scale\u003c/p\u003e\n\u003cp\u003eCS - Coping Style\u003c/p\u003e\n\u003cp\u003eEWB - Emotional Well-Being\u003c/p\u003e\n\u003cp\u003eFACT-Bv4.0 - Functional Assessment of Cancer Therapy\u0026ndash;Breast version 4.0\u003c/p\u003e\n\u003cp\u003eFWB - Functional Well-Being\u003c/p\u003e\n\u003cp\u003eHRQoL - Health-Related Quality of Life\u003c/p\u003e\n\u003cp\u003eMCMQ - Medical Coping Mode questionnaire\u003c/p\u003e\n\u003cp\u003eMSPSS - Multidimensional Scale of Perceived Social Support\u003c/p\u003e\n\u003cp\u003eNSM - Neuman Systems Model\u003c/p\u003e\n\u003cp\u003ePWB - Physical Well-Being\u003c/p\u003e\n\u003cp\u003eRMSEA - Root Mean Square Error of Approximation\u003c/p\u003e\n\u003cp\u003eSD - Standard Deviation\u003c/p\u003e\n\u003cp\u003eSEM - Structural Equation Modeling\u003c/p\u003e\n\u003cp\u003eSWB - Social Well-Being\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e: The Human Research Ethics Committee of Xi\u0026rsquo;an Jiaotong University reviewed and approved the study protocol (2018-9800). Written informed consent was obtained from each patient before administering the questionnaire survey. Furthermore, the study conforms to the standards contained in the Declaration of Helsinki, as amended.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e: Not applicable.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e: The authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e: The study was supported by China Postdoctoral Science Foundation (No. 2018M643678). The funding body had no role in the design of the study and collection, analysis, and interpretation of data or in writing the manuscript.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor Contributions\u003c/strong\u003e: KZ and XL designed the study. LL, WZ, XB, MZ, and DH collected the data. KZ analyzed and interpreted the data, and prepared the manuscript draft. KZ and XL revised the manuscript. All authors read and approved the final manuscript.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e: We thank the China Postdoctoral Science Foundation (No. 2018M643678) for their funding support.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eOh PJ, Cho JR. Changes in fatigue, psychological distress, and quality of life after chemotherapy in women with breast cancer: A prospective study. 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Qual Life Res. 2020;29(5):1271\u0026ndash;9. doi: 10.1007/s11136-019-02401-8\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eTable 1\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e. Participants\u0026rsquo; socio-demographic, clinical characteristics, and summary results for the four questionnaires (\u003cem\u003eN\u003c/em\u003e = 431)\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 100.0%; border-collapse: collapse;\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eMean \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e SD\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003en\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eSocio-Demographic Characteristics\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eAge (years; mean \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e SD\u003csup\u003ea\u003c/sup\u003e; range: 27\u0026ndash;77)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e48.26 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 10.40\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eEducation Level\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ePrimary \u0026amp; Below\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e90 (20.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eSecondary\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e278 (64.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eTertiary\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e63 (14.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eMarital status\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eMarried\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e425 (98.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eOther Marital Status\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e6 (1.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eHas Children\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e416 (96.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e15 (3.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eEmployment Status\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eUnemployed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e170 (39.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eRetired\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e54 (12.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eEmployed\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e207 (48.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eAverage monthly income over the past 12 months (Chinese Yuan)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026lt;3000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e170 (39.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e3000\u0026ndash;6000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e194 (45.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e6001\u0026ndash;9000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e52 (12.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026gt;9000\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e15 (3.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ePlace of Residence\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eUrban\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e207 (48.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eRural\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e224 (52.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eChronic Disease (disease course \u0026gt; 6 months)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eYes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e28 (6.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eNo\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e403 (93.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eClinical Characteristics\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eIllness Stage\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0-I\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e134 (31.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eII\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e203 (47.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eIII\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e66 (15.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eIV\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e28 (6.5)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eMetastasis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eNo Metastasis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e285 (66.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eAxillary\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e119 (27.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eOther Metastasis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e27 (6.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eSurgical Style \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eNo Surgery\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e146 (33.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eModified Radical Mastectomy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e203 (47.1)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eSimple Mastectomy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e60 (13.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eBreast Conservation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e23 (5.3)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eAdjuvant Therapy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eConventional Chemotherapy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e381 (88.4)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eNeoadjuvant Chemotherapy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e26 (6.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eRadio Therapy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e151 (35.0)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eEndocrine Therapy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e231 (53.6)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eTargeted Therapy\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e47 (10.9)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eHRQoL\u003c/span\u003e\u003c/strong\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ePhysical Well-Being\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e17.75 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 4.91\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eSocial/Family Well-Being\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e17.66 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 5.95\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eEmotional Well-Being\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e14.29 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 4.48\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eFunctional Well-Being\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e13.24 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 5.04\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"margin-left: .25in; text-align: left; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eBreast-Cancer-Specific \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eSubscales for additional concerns\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e24.81 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 3.97\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eFACT-Bv4.0\u003csup\u003ec\u003c/sup\u003e Total Score\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e87.74 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 18.69\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eResilience\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eTenacity\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e27.51 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 8.19\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eSelf-Reliance\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e16.84 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 4.42\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eOptimism\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e10.37 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 3.06\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eCD-RISC\u003csup\u003ed\u003c/sup\u003e Total Score\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e54.72 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 14.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ePerceived Social Support\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eFamily support\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e24.16 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 3.24\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eFriends support\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e20.76 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 4.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eSignificant others support\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e20.52 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 4.17\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eMSPSS\u003csup\u003ee\u003c/sup\u003e total score\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e65.45 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 9.40\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eCoping Style\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eConfrontation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e19.87 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 3.73\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eAvoidance\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e16.70 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 1.90\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 55.9%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"55%\"\u003e\n\u003cp style=\"text-indent: .25in; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eResignation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.06%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e9.57 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 2.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 22.04%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"22%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 35.55pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e SD: standard deviation\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e health-related quality of life \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ec\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e Functional Assessment of Cancer Therapy\u0026ndash;Breast version 4.0\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ed\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e Connor-Davidson Resilience scale\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ee\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e Multidimensional Scale of Perceived Social Support\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eTable 2\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e. Comparisons of resilience, social support, coping styles, and corresponding norms (\u003cem\u003eN\u003c/em\u003e = 431)\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 100.0%; border-collapse: collapse;\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.54%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"31%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eScore\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eMean \u0026plusmn; SD\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eNorm\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.26%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eMD\u003c/span\u003e\u003c/strong\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 15.72%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"15%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e95% CI\u003c/span\u003e\u003c/strong\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.18%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.54%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"31%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eResilience\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e(\u003cem\u003eN\u003c/em\u003e = 560)\u003csup\u003ee\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.26%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 15.72%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"15%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.18%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.54%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"31%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eCD-RISC\u003csup\u003ec\u003c/sup\u003e Total Score\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e54.72 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 14.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e65.4 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 13.9\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.26%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e-10.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 15.72%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"15%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e-12.59, -8.77\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.18%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.54%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"31%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ePerceived Social Support\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e(\u003cem\u003eN\u003c/em\u003e = 1589)\u003csup\u003ef\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.26%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 15.72%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"15%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.18%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.54%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"31%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eMSPSS\u003csup\u003ed\u003c/sup\u003e total score\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e65.45 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 9.40\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e68.91 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 11.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.26%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e-3.46\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 15.72%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"15%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e-4.68, -2.24\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.18%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.54%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"31%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eCoping Style\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e(\u003cem\u003eN\u003c/em\u003e = 701)\u003csup\u003eg\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.26%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 15.72%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"15%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.18%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.54%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"31%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eConfrontation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e19.87 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 3.73\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e19.48 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 3.81\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.26%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.39\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 15.72%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"15%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e-0.10, 0.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.18%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.54%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"31%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eAvoidance\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e16.70 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 1.90\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e14.44 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 2.97\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.26%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e2.25\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 15.72%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"15%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e2.01, 2.50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.18%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 31.54%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"31%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eResignation\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e9.57 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 2.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 16.66%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"16%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e8.81 \u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e 3.17\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 9.26%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"9%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 15.72%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"15%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.39, 1.13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 10.18%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"10%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12pt; line-height: 200%; font-family: 'Times New Roman', serif;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e mean difference\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e confidence interval\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ec\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e Connor-Davidson Resilience scale\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ed\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e Multidimensional Scale of Perceived Social Support \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ee \u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eAdapted from: Ren Y, Zhou Y, Ma C, et al. Influence of psychological resilience on job satisfaction of nurses. Chin Nurs Res. 2014;28(1C): 293\u0026ndash;4.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ef\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e Adapted from: Wang Y, Liu C. The mediating effects of social support and coping style between nurses\u0026rsquo; personality characteristics and mental health. Chin J Nurs Educ. 2019;16(7): 536\u0026ndash;40.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eg\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e Adapted from: Shen X, Jiang Q. Report on application of Chinese version of MCMQ in 701 patients. Chin J Behav Med Sci. 2000;9(1):18\u0026ndash;20.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eTable 3\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e. Independent predictors of health-related quality of life (\u003cem\u003eN\u003c/em\u003e = 431)\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 100.0%; border-collapse: collapse;\" width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eIndependent Variables\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eB\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e (95% CI)\u003csup\u003ed\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; border-top: solid windowtext 1.0pt; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cem\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eP\u003c/span\u003e\u003c/em\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eModel A\u003c/span\u003e\u003c/strong\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; border: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"text-indent: 9.0pt; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eResilience\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.75 (0.59, 0.92)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"text-indent: 9.0pt; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ePerceived Social Support\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.29 (0.06, 0.51)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.014\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"text-indent: 9.0pt; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eCoping Style (Confrontation)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.60 (0.01, 1.19)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.046\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eModel B\u003c/span\u003e\u003c/strong\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"text-indent: 9.0pt; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eResilience\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.81 (0.66, 0.97)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"text-indent: 9.0pt; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ePerceived Social Support\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.28 (0.05, 0.51)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.016\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"text-indent: 9.0pt; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eCoping Style (Avoidance)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.82 (-0.07, 1.71)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.070\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eModel C\u003c/span\u003e\u003c/strong\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ec\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"text-indent: 9.0pt; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eResilience\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.64 (0.47, 0.81)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"text-indent: 9.0pt; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ePerceived Social Support\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.22 (0.002, 0.45)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e0.048\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 48.5%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"48%\"\u003e\n\u003cp style=\"text-indent: 9.0pt; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eCoping Style (Resignation)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 34.28%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"34%\"\u003e\n\u003cp style=\"text-align: center; line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e-1.68 (-2.48, -0.89)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 17.22%; border: none; border-bottom: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"17%\"\u003e\n\u003cp style=\"text-align: left; line-height: 200%; tab-stops: decimal 22.6pt; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003cspan style=\"font-size: 12pt; line-height: 200%; font-family: 'Times New Roman', serif;\"\u003eA multivariate linear regression analysis was performed after controlling for the following dummy variables: education level (ref. primary and below), marital status (ref. married), has children (ref. yes), employment status (ref. unemployed), average monthly income over the past 12 months (Chinese Yuan) (ref. \u0026lt;3000), place of residence (ref. urban), chronic disease (ref. yes), illness stage (ref. 0\u0026ndash;I), metastasis (ref. no metastasis), surgical style (ref. no surgery), adjuvant therapy (ref. conventional chemotherapy), and continuous characteristics (age).\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ea\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e \u003cem\u003eR\u003c/em\u003e = 0.80, \u003cem\u003eR\u003c/em\u003e\u003csup\u003e2\u003c/sup\u003e = 0.64, \u003cem\u003eF\u003c/em\u003e = 14.33, \u003cem\u003eP\u003c/em\u003e \u0026lt; 0.001.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e \u003cem\u003eR\u003c/em\u003e = 0.80, \u003cem\u003eR\u003c/em\u003e\u003csup\u003e2\u003c/sup\u003e = 0.64, \u003cem\u003eF\u003c/em\u003e = 14.25, \u003cem\u003eP\u003c/em\u003e \u0026lt; 0.001.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ec\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e \u003cem\u003eR\u003c/em\u003e = 0.81, \u003cem\u003eR\u003c/em\u003e\u003csup\u003e2\u003c/sup\u003e = 0.66, \u003cem\u003eF\u003c/em\u003e = 15.76, \u003cem\u003eP\u003c/em\u003e \u0026lt; 0.001.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"line-height: 200%; layout-grid-mode: char;\"\u003e\u003csup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003ed\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size: 12.0pt; line-height: 200%; font-family: 'Times New Roman',serif;\"\u003e confidence interval\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"breast cancer, resilience, perceived social support, coping style, health-related quality of life","lastPublishedDoi":"10.21203/rs.3.rs-42009/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-42009/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Background: Breast cancer may impair health-related quality of life (HRQoL). We examined the mediating roles of perceived social support (PSS) and coping style (CS) in the relationship between resilience and HRQoL in newly diagnosed breast cancer patients.\n\nMethods: Four-hundred thirty-one patients completed a survey at two hospitals in Shaanxi Province, China, using self-report measures assessing HRQoL, resilience, PSS, and CS. A one-sample t-test analyzed differences between resilience, PSS, and CS in breast cancer patients and the corresponding norm. Multivariate linear regression analyzed the independent predictors of HRQoL. The mediating roles of PSS and CS between resilience and HRQoL were investigated using structural equation modeling (SEM).\n\nResults: Participants had significantly lower scores for resilience and PSS and higher scores for the avoidance and resignation CSs than their corresponding norm. SEM analysis showed resilience had significant direct effects on PSS (B = 0.59, 95% CI [0.49, 0.68], P = 0.003), CS (confrontation: B = 0.53, 95% CI [0.44, 0.62], P = 0.001; resignation: B = -0.66, 95% CI [-0.74, -0.57], P = 0.002), and HRQoL (B range from 0.54–0.58). Resilience had significant indirect effects (B range from 0.09–0.27), and PSS and CS had significant direct effects on HRQoL (P \u003c 0.05).\n\nConclusions: Newly diagnosed breast cancer patients had lower resilience and PSS and higher negative CSs. PSS and CS appeared to mediate the influence of resilience on HRQoL. Multimodal intervention programs focusing on PSS and CS might increase the influence of resilience on HRQoL in breast cancer patients.","manuscriptTitle":"Perceived social support and coping style as mediators between resilience and health-related Quality of Life in women newly diagnosed with breast cancer: A cross-sectional study","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2020-10-30 18:30:31","doi":"10.21203/rs.3.rs-42009/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-07-20 13:51:36","doi":"10.21203/rs.3.rs-42009/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"e11c801b-3f57-41c5-b326-cb2dc1a27ac2","owner":[],"postedDate":"October 30th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":937695,"name":"Health Economics \u0026 Outcomes Research"},{"id":937696,"name":"Oncology"}],"tags":[],"updatedAt":"2021-01-06T12:51:33+00:00","versionOfRecord":[],"versionCreatedAt":"2020-10-30 18:30:31","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-42009","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-42009","identity":"rs-42009","version":["v2"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}