Deterioraron of Ovarian Function After Total Abdominal Hysterectomy with Preservaron of Ovaries

Arijit Singha, Sudipta Saha, Rana Bhattacharjee, Samim Ali Mondal, Subhadip Choudhuri, Dibakar Biswas, S. Das, Sujoy Ghosh, Satinath Mukhopadhyay, Subhankar Chowdhury
In: Endocrine Practice · 2016 · vol. 22(12) , pp. 1387–1392 · doi:10.4158/ep161215.or · PMID:27540878 · W2510713965
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This study investigated ovarian function after total abdominal hysterectomy with ovarian preservation and found it deteriorated.

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Abstract

ObjectiveTo evaluate ovarian function after total abdominal hysterectomy in premenopausal women.MethodsIn the present cross-sectional study, we enrolled 52 healthy female subjects having normal menstrual cycle as controls and 37 female patients (age <45 years) who had undergone total abdominal hysterectomy (TAH) with preservation of at least one ovary for the evaluation of ovarian function. Serum antimüllerian hormone (AMH) and follicle-stimulating hormone (FSH) were measured by enzyme-linked immunosorbent assay in both groups. Transvaginal Doppler ultrasonography was done to measure ovarian stromal blood flow indices (resistive index [RI] and pulsatility index [PI]). The means obtained from different sample groups were compared using the nonparametric Mann-Whitney U test, and correlations between two variables were evaluated using the Spearman nonparametric correlation test. A value of P<.05 was considered statistically significant.ResultsMean postoperative duration of patients who had undergone hysterectomy was 2.5 years. Mean serum AMH level was 7.68 ± 6.70 ng/mL in the cases, significantly lower than the level in controls (10.98 ± 7.83 ng/mL) (P = .016). Serum FSH level in controls was 12.01 ± 6.27 μIU/mL, which was significantly higher in the cases (20.27 ± 12.91 μIU/mL) (P = .001). An inverse correlation between serum AMH and FSH was observed (P = .0006; r = -0.4583). However, the ovary RI and PI values in both groups were similar.ConclusionTAH affects ovarian function, despite normal ovarian blood supply.AbbreviationsAMH = antimüllerian hormone FSH = follicle-stimulating hormone RI = resistive index PI = pulsatility index TAH = total abdominal hysterectomy.

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