Prevalence and Factors Associated with Dyslipidemia among Patients with Helicobacter Pylori Infection Attending Fort Portal Regional Referral Hospital in Uganda: A crossectional study

Prevalence and Factors Associated with Dyslipidemia among Patients with Helicobacter Pylori Infection Attending Fort Portal Regional Referral Hospital in Uganda: A crossectional study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Prevalence and Factors Associated with Dyslipidemia among Patients with Helicobacter Pylori Infection Attending Fort Portal Regional Referral Hospital in Uganda: A crossectional study François Bisingurege Kagoro, Jacinto Amandua, Charles L. Abonga, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4929147/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background : Cardiovascular disease is the number one cause of death worldwide while dyslipidemia is key modifiable risk factor of atherosclerotic cardiovascular disease accounting for 4 million deaths annually worldwide. Few studies assessing the relationship between H. pylori and dyslipidemia show changes in serum levels of lipids. The aim of this study was to determine the prevalence and factors associated with dyslipidemia among patients with H. pylori infection. Methods : A cross-sectional study was performed between September to December 2022 at Fort Portal regional referral hospital, Uganda on 380 H. pylori infected patients. A validated questionnaire and 5-mL blood specimens were used to obtain data. Correlation analyses, chi-square tests, t-tests, and logistic regression were used to detect correlations and associations, with adjusted odds ratios and p values considered significant at values ≤0.05. Results : According to the individual lipid profile parameters in this study, decreased HDL-C (24.21%) was the most common dyslipidemia form, followed by elevated LDL-C (16.58%), elevated triglycerides (13.42%), and elevated total cholesterol (11.32%). The prevalence of dyslipidemia among patients with H. pylori infection was 41.58% at Fort Portal Regional Referral Hospital. In this study, religion and education level were independently associated with dyslipidemia, that is, Muslims had a 5-fold increased risk compared to Pentecostal believers aOR 4.97 (95% CI 1.57-15.73, p 0.006), while primary education level conferred a tripled risk compared to tertiary level education aOR 3.21 (95% CI 1.17-8.78, p= 0.023). Conclusion : The high prevalence of dyslipidemia among H. pylori patients merits that country-wide awareness programs on dyslipidemia should be carried out, and that patients with H. pylori infection, overweight people, and hypertensive patients should have routine screening for dyslipidemia as they could potentially benefit from lipid-reducing regimens. H. pylori Dyslipidemia Prevalence Risk factors LDL-C HDL-C Total cholesterol Triglycerides Cardiovascular disease Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4929147","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":348897375,"identity":"b911f880-04bb-4c6b-873b-e5c5b626bdae","order_by":0,"name":"François Bisingurege Kagoro","email":"data:image/png;base64,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","orcid":"","institution":"Kampala International University -Western Campus","correspondingAuthor":true,"prefix":"","firstName":"François","middleName":"Bisingurege","lastName":"Kagoro","suffix":""},{"id":348897376,"identity":"21e4bd60-81c9-4e6d-849b-bb1928fdfad7","order_by":1,"name":"Jacinto Amandua","email":"","orcid":"","institution":"Kampala International University -Western Campus","correspondingAuthor":false,"prefix":"","firstName":"Jacinto","middleName":"","lastName":"Amandua","suffix":""},{"id":348897377,"identity":"91cff09e-a00e-438f-89b1-837ccb51ddad","order_by":2,"name":"Charles L. 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Few studies assessing the relationship between H. pylori and dyslipidemia show changes in serum levels of lipids. The aim of this study was to determine the prevalence and factors associated with dyslipidemia among patients with H. pylori infection.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: A cross-sectional study was performed between September to December 2022 at Fort Portal regional referral hospital, Uganda on 380 H. pylori infected patients. A validated questionnaire and 5-mL blood specimens were used to obtain data. Correlation analyses, chi-square tests, t-tests, and logistic regression were used to detect correlations and associations, with adjusted odds ratios and p values considered significant at values ≤0.05.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: According to the individual lipid profile parameters in this study, decreased HDL-C (24.21%) was the most common dyslipidemia form, followed by elevated LDL-C (16.58%), elevated triglycerides (13.42%), and elevated total cholesterol (11.32%). The prevalence of dyslipidemia among patients with H. pylori infection was 41.58% at Fort Portal Regional Referral Hospital. 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