[Histopathological diagnosis of Barrett's mucosa and associated neoplasias. Results of a consensus conference of the Working Group for "Gastroenterological Pathology of the German Society for Pathology" on 22 September 2001].

Zusammenfassung Die Diagnostik der Barrett-Schleimhaut und ihrer verschiedenen Grade der intraepithelialen Neoplasie (früher: Dysplasie) gilt in mehreren Aspekten als schwierig. Auf einer Konsensus-Konferenz der Arbeitsgemeinschaft "Gastroenterologische Pathologie der Deutschen Gesellschaft für Pathologie" wurde daher versucht eine Standardisierung der histopathologischen Diagnostik in folgenden Punkten zu erarbeiten: Diagnostik und Terminologie der Barrett-Mukosa, Abgrenzung der Barrett-Mukosa von der intestinalen Metaplasie der Kardia, diagnostische Kriterien der intraepithelialen Neoplasie, Anzahl der zu entnehmenden Biopsien sowie Wertigkeit zusätzlicher immunhistologischer und/oder molekularbiologischer Methoden. Abschließend wurde eine Empfehlung zur Einholung einer "zweiten Meinung" bei intraepithelialer Neoplasie formuliert. Abstract There are a number of difficulties regarding the diagnosis of Barrett's mucosa and the varying grades of neoplasia that may be associated with it. It was therefore the aim of a consensus conference of the "Working Group for Gastroenterological Pathology within the German Society of Pathology" to achieve standardization regarding the following issues: definition and diagnostic criteria for Barrett's mucosa and its discrimination from intestinal metaplasia of the cardia, diagnostic criteria for intraepithelial neoplasia, number of biopsies necessary to establish the diagnosis, significance of additional immunohistochemical and/or molecular biological methods as well as importance of a second opinion in the diagnosis of intraepithelial neoplasia. Similar content being viewed by others Literatur Alikhan M, Rex D, Khan A, Rahmani E, Cummings O, Ulbright TM (1999) Variable pathologic interpretation of columnar lined esophagus by general pathologists in community practice. Gastrointest Endosc 50:23–26 Falk GW (2002) Barrett's esophagus. Gastroenterology 122:1569–1591 Geboes K, Eyken P van (2000) The diagnosis of dysplasia and malignancy in Barrett's oesophagus. Histopathology 37:99–107 Montgomery E, Bronner MP, Goldblum JR et al. (2001) Reproducibility of the diagnosis of dysplasia in Barrett esophagus: a reaffirmation. Hum Pathol 32:368–378 Reid BJ (1991) Barrett's esophagus and esophageal adenocarcinoma. Gastroenterol Clin North Am 20:817–834 Reid BJ, Haggitt RC, Rubin CE et al. (1988) Observer variation in the diagnosis of dysplasia in Barrett's esophagus. Hum Pathol 19:166–178 Skacel M, Petras RE, Gramlich TL, Sigel JE, Richter JE, Goldblum JR (2000) The diagnosis of low-grade dysplasia in Barrett's esophagus and its implications for disease progression. Am J Gastroenterol 95:3383–3387 Spechler SJ, Goyal RK (1996) The columnar-lined esophagus, intestinal metaplasia, and Norman Barrett. Gastroenterology 110:614–621 Vieth M, Seitz G (2001) 50 Jahre Barrett Ösophagus. Aktuelle diagnostische Möglichkeiten in der Pathologie. Pathologe 22:62–71 Werner M, Mueller J, Walch A, Hofler H (1999) The molecular pathology of Barrett's esophagus. Histol Histopathol 14:553–559 11 Werner M, Flejou JF, Hanaut P, Höfler H, Lambert R, Keller G, Stein HJ (2000) Adenocarcinoma of the oesophagus. In: Hamilton SR, Aaltonen LA (eds) Pathology and genetics of tumours of the digestive system. IARC Press, Lyon, pp 20–26 Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Faller, G., Berndt, R., Borchard, F. et al. Histopathologische Diagnostik der Barrett-Schleimhaut und ihrer Neoplasien. Pathologe 24, 9–14 (2003). https://doi.org/10.1007/s00292-002-0600-y Published: Issue date: DOI: https://doi.org/10.1007/s00292-002-0600-y