Clinico-demographic profile, endoscopic findings and pregnancy outcomes in women with primary infertility: a decade of experience

In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2026 · vol. 15(7) , pp. 2704–2709 · doi:10.18203/2320-1770.ijrcog20262125 · W7166046304
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Combined hystero-laparoscopy identified pelvic or intrauterine abnormalities in 72.4% of women with primary infertility, leading to a 59.2% conception rate after intervention.

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This retrospective study evaluated the diagnostic and therapeutic value of combined hystero-laparoscopy in 304 women with primary infertility over a ten-year period. The procedure identified pelvic or intrauterine abnormalities in 72.4% of patients, with polycystic ovaries, endometriosis, and pelvic adhesions being the most frequent findings. Following surgical management, the overall conception rate was 59.2%, although women diagnosed with endometriosis experienced significantly lower pregnancy rates compared to those without the condition. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

Background: Infertility affects a significant proportion of reproductive-age couples worldwide. Conventional investigations may fail to identify subtle pelvic and intrauterine pathologies that contribute to infertility in all cases. Combined hystero-laparoscopy offers the advantage of simultaneous diagnosis and treatment of such abnormalities. Objective was to analyse the clinico-demographic characteristics, endoscopic findings, management strategies, and pregnancy outcomes of women with primary infertility over a 10 year period at a tertiary care center. Methods: This retrospective observational study included 304 women who underwent combined hystero-laparoscopy for infertility evaluation at a tertiary care center. Demographic characteristics, hysteroscopic findings, laparoscopic findings, therapeutic interventions, and subsequent pregnancy outcomes were analysed. Continuous variables were expressed as mean±SD, while categorical variables were presented as frequencies and percentages. Results: The mean age of the study population was 29.1±4.1 years, and the mean duration of infertility was 7.6±3.0 years. Primary infertility was observed in 84.2% of women. Combined hystero-laparoscopy detected pelvic or intrauterine abnormalities in 72.4% of patients. Hysteroscopic abnormalities were identified in 11.8%, whereas laparoscopic abnormalities were noted in 68.4%. Polycystic ovaries (40.8%), endometriosis (23.7%), and pelvic adhesions (13.2%) were the most common findings. Following evaluation and appropriate surgical management, an overall conception rate of 59.2% was achieved. Women with endometriosis demonstrated lower conception rates compared with those without endometriosis. Conclusions: Combined hystero-laparoscopy remains a valuable diagnostic and therapeutic modality in infertility, particularly in women with unexplained infertility or suspected pelvic pathology. The procedure enables detection and correction of abnormalities that may not be identified through routine investigations and is associated with favourable reproductive outcomes.
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Background

Infertility affects a significant proportion of reproductive-age couples worldwide. Conventional investigations may fail to identify subtle pelvic and intrauterine pathologies that contribute to infertility in all cases. Combined hystero-laparoscopy offers the advantage of simultaneous diagnosis and treatment of such abnormalities. Objective was to analyse the clinico-demographic characteristics, endoscopic findings, management strategies, and pregnancy outcomes of women with primary infertility over a 10 year period at a tertiary care center.

Methods

This retrospective observational study included 304 women who underwent combined hystero-laparoscopy for infertility evaluation at a tertiary care center. Demographic characteristics, hysteroscopic findings, laparoscopic findings, therapeutic interventions, and subsequent pregnancy outcomes were analysed. Continuous variables were expressed as mean±SD, while categorical variables were presented as frequencies and percentages.

Results

The mean age of the study population was 29.1±4.1 years, and the mean duration of infertility was 7.6±3.0 years. Primary infertility was observed in 84.2% of women. Combined hystero-laparoscopy detected pelvic or intrauterine abnormalities in 72.4% of patients. Hysteroscopic abnormalities were identified in 11.8%, whereas laparoscopic abnormalities were noted in 68.4%. Polycystic ovaries (40.8%), endometriosis (23.7%), and pelvic adhesions (13.2%) were the most common findings. Following evaluation and appropriate surgical management, an overall conception rate of 59.2% was achieved. Women with endometriosis demonstrated lower conception rates compared with those without endometriosis.

Conclusions

Combined hystero-laparoscopy remains a valuable diagnostic and therapeutic modality in infertility, particularly in women with unexplained infertility or suspected pelvic pathology. The procedure enables detection and correction of abnormalities that may not be identified through routine investigations and is associated with favourable reproductive outcomes. Metrics

References

Practice Committee of the American Society for Reproductive Medicine. Fertility evaluation of infertile women. Fertil Steril. 2021;116(5):1255-65. DOI: https://doi.org/10.1016/j.fertnstert.2021.08.038 Nayak PK, Mahapatra PC, Mallick J, Swain S, Mitra S, Sahoo J. Role of diagnostic hystero-laparoscopy in evaluation of infertility. J Hum Reprod Sci. 2013;6(1):32-4. DOI: https://doi.org/10.4103/0974-1208.112378 Pundir J, El-Toukhy T. Uterine cavity assessment prior to IVF. Womens Health (Lond). 2010;6(6):841-8. Bulletti C, Coccia ME, Battistoni S, Borini A. Endometriosis and infertility. J Assist Reprod Genet. 2010;27(8):441-7. DOI: https://doi.org/10.1007/s10815-010-9436-1 Tanahatoe SJ, Hompes PG, Lambalk CB. Investigation of the infertile couple: should diagnostic laparoscopy be performed in all infertile women? Hum Reprod. 2003;18(1):8-11. Sharma R, Sharma V, Sharma S. Role of hysterolaparoscopy in evaluation of infertility. Int J Reprod Contracept Obstet Gynecol. 2016;5(11):3985-9. Balen AH, Morley LC, Misso M, Franks S, Legro RS, Wijeyaratne CN, et al. The management of anovulatory infertility in women with polycystic ovary syndrome. Hum Reprod Update. 2016;22(6):687-708. DOI: https://doi.org/10.1093/humupd/dmw025 Amer SA, Li TC, Ledger WL. Ovulation induction using laparoscopic ovarian drilling in women with polycystic ovarian syndrome. Hum Fertil. 2004;7(1):9-15. DOI: https://doi.org/10.1093/humrep/deh343 Meuleman C, Vandenabeele B, Fieuws S, Spiessens C, Timmerman D, D’Hooghe T. High prevalence of endometriosis in infertile women. Hum Reprod. 2009;24(5):1097-103. Macer ML, Taylor HS. Endometriosis and infertility. Fertil Steril. 2012;98(3):511-9. Harb HM, Gallos ID, Chu J, Harb M, Coomarasamy A. The effect of endometriosis on in vitro fertilisation outcome. Hum Reprod Update. 2013;19(6):625-39. Tulandi T, Al-Shahrani AA. Adhesion prevention in gynecologic surgery. Obstet Gynecol Surv. 2013;68(3):197-206. Fatemi HM, Kasius JC, Timmermans A, Van Disseldorp J, Fauser BC, Devroey P, et al. Prevalence of unsuspected uterine cavity abnormalities diagnosed by office hysteroscopy. Hum Reprod. 2010;25(8):1959-65. DOI: https://doi.org/10.1093/humrep/deq150 Pundir J, El-Toukhy T. Uterine cavity assessment prior to IVF. Womens Health (Lond). 2010;6(6):841-8. DOI: https://doi.org/10.2217/WHE.10.61 Tanahatoe SJ, Hompes PG, Lambalk CB. Investigation of the infertile couple: should diagnostic laparoscopy be performed in all infertile women? Hum Reprod. 2003;18(1):8-11. DOI: https://doi.org/10.1093/humrep/deg034 Corson SL, Cheng A, Gutmann JN. Laparoscopy in the normal infertile patient. J Am Assoc Gynecol Laparosc. 2000;7(3):317-24. DOI: https://doi.org/10.1016/S1074-3804(05)60473-2

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