Lack of Modifying Effect of Arctiin on ENU-Induced Uterine Carcinogenesis in ICR Mice

Yuji Okuhara, Tsuyoshi Kitamura, Morimichi Hayashi, Tatsuya Nagasawa, Toru Tamura, Junji Kuroda, Nobuo Shibata, Kunitoshi Mitsumori
In: Journal of Toxicologic Pathology · 2007 · vol. 20(3) , pp. 149–153 · doi:10.1293/tox.20.149 · W2029798267
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Arctiin did not significantly alter the incidence or severity of N-ethyl-N-nitrosourea-induced uterine proliferative lesions in ICR mice.

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This study investigated whether arctiin, a lignan derived from burdock seeds, modifies uterine carcinogenesis initiated by N-ethyl-N-nitrosourea in female ICR mice. The researchers administered ENU via intra-uterine injection and subsequently fed the animals diets containing varying concentrations of arctiin for 26 weeks. Histopathological analysis revealed that while uterine proliferative lesions such as adenocarcinoma, atypical hyperplasia, and endometrial hyperplasia developed across all groups, the incidence and severity of these conditions did not differ significantly between the control and arctiin-treated cohorts. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The present study was performed to investigate the modifying effects of arctiin, a plant lignan isolated from Arctium lappa (burdock) seeds, on uterine carcinogenesis induced by N-ethyl-N-nitrosourea (ENU) initiation in mice. Female ICR mice aged 5 weeks were administered a single intra-uterine injection of ENU at a dose of 50 mg/kg via the vagina. After 1 week, the animals were fed a soybean-free diet containing 0 (control), 0.004, 0.02 and 0.1% of arctiin for 26 weeks. Histopathological examinations revealed the development of uterine proliferative lesions such as adenocarcinoma, atypical hyperplasia, adenomyosis, and endometrial hyperplasia. However, there were no significant differences in the incidences and severities of these lesions among the groups. These results indicate that arctiin showed no definite modifying effects on uterine carcinogenesis under the present experimental conditions.
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Originals Lack of Modifying Effect of Arctiin on ENU-Induced Uterine Carcinogenesis in ICR Mice 2007 Volume 20 Issue 3 Pages 149-153 Details Abstract The present study was performed to investigate the modifying effects of arctiin, a plant lignan isolated from Arctium lappa (burdock) seeds, on uterine carcinogenesis induced by N-ethyl-N-nitrosourea (ENU) initiation in mice. Female ICR mice aged 5 weeks were administered a single intra-uterine injection of ENU at a dose of 50 mg/kg via the vagina. After 1 week, the animals were fed a soybean-free diet containing 0 (control), 0.004, 0.02 and 0.1% of arctiin for 26 weeks. Histopathological examinations revealed the development of uterine proliferative lesions such as adenocarcinoma, atypical hyperplasia, adenomyosis, and endometrial hyperplasia. However, there were no significant differences in the incidences and severities of these lesions among the groups. These results indicate that arctiin showed no definite modifying effects on uterine carcinogenesis under the present experimental conditions. © 2007 The Japanese Society of Toxicologic Pathology Favorites & Alerts Recently viewed articles

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