Content of estrone and estrogen metabolites in tissues of hysterocarcinoma, adenomyosis, and hysteromyoma tissue.

e22214 Background: The significance of autocrine tumor growth regulation and the role of hyperestrogenism in pathogenesis of hyperplastic processes of women's reproductive organs has not been determined so far. Methods: The IFA method was used for determining the content of estrone (E1) and estradiol (E2) in the hysterocarcinoma tissue (HC, n=25), adenomyosis of uterus (A, n=26), myoma tissue (M, n=30) as independent variants and in 29 patients having the combination of the above.The patients were aged 35-49, all women were in the reproductive period. The control was visually unchanged uterine body tissue. Results: Under A the levels of E1and E2 were 1.3 and 2 times higher than the value of the intact tissue, respectively. Under M the level of E1 was 1.6 times as high as that of the intact tissue, with the content of E2 being the same. On the contrary, under the HC, the level of E1 was 1.6 times lower as compared to the indicator in the intact skin, but, similarly, with E2 normal. If the three processes (HC, A and M) are combined, the content of E2 was on average 2 times higher than the norm as for all tissues studied. Under HC, A and M combined, the level of E1 was reduced in the A and M tissues in 2.4 and 2.5 times, respectively, while it was reduced in 1.2 in the HC tissue. Under the independent A and HC, E1/E2 was lower than the norm on average in 1.6 times and it was 69% higher than the norm under the independent M. In the combination process occurs unification E1/E2: decreased an average of 5.8 times compared to intact tissue Conclusions: It has been demonstrated that independently developing HC, adenomyosis and uterine myoma are featured by the individual local hormonogenesis. The results obtained allow concluding that under combined pathology the hyperplastic processes influence each other, which is most brightly reflected by the unifying of E1/E2 ratio.