Endometrial CXCL13 Expression Is Cycle Regulated in Humans and Aberrantly Expressed in Humans and Rhesus Macaques With Endometriosis

Bruce A. Lessey, Jason M. Franasiak, Steven L. Young, Ov D. Slayden, Lingwen Yuan, Katherine A. Burns, Kenneth S. Korach, Marc A. Fritz
2020 · doi:10.17615/axdf-es78 · W4298066141
article OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

CXCL13 messenger RNA expression in the human and rhesus macaque endometrium is low in the proliferative phase and high in the secretory phase, but is aberrantly increased in the proliferative phase in endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

The paper examined how the chemokine CXCL13 is expressed in human endometrium across the menstrual cycle and whether its expression differs in the setting of endometriosis. Using human tissue analyses and a rhesus macaque model, the authors found that endometrial CXCL13 expression is cycle regulated in humans, with aberrant CXCL13 expression observed in both humans and rhesus macaques with endometriosis. A key caveat is that the study relies on expression measurements in tissue samples, which do not directly establish functional causality for CXCL13 in disease mechanisms. This paper is centrally about endometriosis — it focuses on cycle-regulated endometrial CXCL13 expression and its aberrant expression in humans and rhesus macaques with endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

C-X-C ligand 13 (CXCL13), a regulator of mucosal immunity, is secreted by human endometrial epithelium and may be involved in embryo implantation. However, cyclic expression of human endometrial CXCL13 in health and disease is not well studied. This study examines cycle stage-specific endometrial CXCL13 expression in normal humans when compared to those with biopsy-confirmed, stage 1 to 4 endometriosis using real-time reverse transcriptase, real-time polymerase chain reaction and immunohistochemistry. Eutopic endometrial CXCL13 expression was also compared between normal, control Rhesus macaques, and macaques with advanced endometriosis. In healthy women, CXLC13 messenger RNA expression was minimal in the proliferative phase and maximal in the secretory phase. However, in the presence of endometriosis, proliferative-phase endometrial expression markedly increased in both humans and rhesus subjects (P < .05). The cross-species and cross-stage concordance suggests a pathophysiologic role for CXCL13 in endometriosis and its use as a biomarker for disease.
Full text 785 characters · extracted from oa-html · click to expand
MLA Franasiak, Jason M, et al. Endometrial Cxcl13 Expression Is Cycle Regulated In Humans and Aberrantly Expressed In Humans and Rhesus Macaques With Endometriosis. 2015. https://doi.org/10.17615/axdf-es78 APA Franasiak, J., Burns, K., Slayden, O., Yuan, L., Fritz, M., Korach, K., Lessey, B., & Young, S. (2015). Endometrial CXCL13 Expression Is Cycle Regulated in Humans and Aberrantly Expressed in Humans and Rhesus Macaques With Endometriosis. https://doi.org/10.17615/axdf-es78 Chicago Franasiak, Jason M., Katherine A Burns, Ov Slayden, Lingwen Yuan, Marc A Fritz, Kenneth S Korach, Bruce A Lessey et al. 2015. Endometrial Cxcl13 Expression Is Cycle Regulated In Humans and Aberrantly Expressed In Humans and Rhesus Macaques With Endometriosis. https://doi.org/10.17615/axdf-es78

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK