EFFECTS OF SOME ANTI-MALARIA DRUGS (CHLOROQUINE, ARTESUNATE AND DIHYDROARTEMISININE) ON SOME HAEMATOLOGICAL PARAMETERS.

The effects of some anti-malaria drugs: Chloroquine, Artesunate and Alaxin (Dihydroartemisinine) on some haematological parameters: packed cell volume, haemoglobin, total white blood cells, neutrophills, lymphocytes, easinophills, coenocytes, the shapes and colours of the blood cells was studied. At different concentrations of chloroquine: 1.44mg/kg, 2.88mg/kg and 4.32mg/kg body weights, the PCV concentration decreased as the concentration of the chloroquine increased. The Hb also decreased at increase in concentration of chloroquine. There was little decrease in the total white blood cells at the concentration of a 1.44 mg/kg. The Neutrophills showed much decrease at different concentrations. While the lymphocytes increased at the administration of chloroquine but, decreased as the concentration increased. At a maximum dose of Artesunate (6mg/kg) the PCV and Hb decreased the total white blood cells decreased at the lower concentration of 2mg/kg. There was also decrease of Neutrophills, while the lymphocytes showed increment. At the administration of dihydroartemisinine the packed cell volume, haemoglobin, total white blood cells, Neutrophills showed decrease as the concentration of dihydroartemisinine increased, while the Lymphocytes increased as the concentration of dihydroartemisinine increased.