Correlation between anemia and phosphorus metabolism in patients with nondialysis chronic kidney disease

Correlation between anemia and phosphorus metabolism in patients with nondialysis chronic kidney disease | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Correlation between anemia and phosphorus metabolism in patients with nondialysis chronic kidney disease Xue Liao, Ao Li, Yian Wang, Jianqing Xu, Dechang Chen, Rongdan Xu, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6456847/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract This study investigated the correlation between anemia and phosphorus metabolism in patients with nondialysis chronic kidney disease (CKD). A total of 196 patients with nondialysis CKD with complete clinical information who were hospitalized in the Department of Nephrology at the Sixth Affiliated Hospital of Kunming Medical University from November 2021 to June 2022 were enrolled. Among these patients, 119 had anemia (anemia group), and 77 did not have anemia (nonanemia group). Univariate logistic regression analysis was performed to analyze the effects of diabetes mellitus (DM), hypertension, and the levels of serum phosphorus, blood calcium, high-sensitivity C-reactive protein (Hs-CRP), and 24-h urinary electrolytes on anemia. Multivariate logistic regression analysis using backward stepwise selection was then performed to further analyze the effect of each factor on anemia. DM, hypertension, the levels of corrected calcium, serum phosphorus, intact parathyroid hormone (iPTH), Hs-CRP, and 24-h urinary phosphorus, and the fractional excretion of phosphorus (FePi) (all P < 0.05) were correlated with the incidence of anemia in patients with CKD. Furthermore, there was a 5.82-fold increase, 0.12-fold decrease, and 0.04-fold increase in the risk of anemia for every 1-mmol/L increase in serum phosphorus (OR = 6.82, 95% CI: 1.32–35.11), 1-mmol/L increase in 24-h urinary phosphorus (OR = 0.88, 95% CI: 0.81–0.91), and 1-mg/dL increase in Hs-CRP (OR = 1.04, 95% CI: 1.01–1.07), respectively. The FePi and serum phosphorus and Hs-CRP levels were independent risk factors, and the 24-h urinary phosphorus level was an independent protective factor for anemia in patients with nondialysis CKD. Health sciences/Nephrology/Kidney Health sciences/Nephrology/Kidney diseases chronic kidney disease (CKD) anemia phosphorus metabolism inflammation Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6456847","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":611501157,"identity":"db6cc32d-b70a-4694-b94f-6137905d46bc","order_by":0,"name":"Xue Liao","email":"","orcid":"","institution":"Zhongshan Hospital of Yuxi City","correspondingAuthor":false,"prefix":"","firstName":"Xue","middleName":"","lastName":"Liao","suffix":""},{"id":611501158,"identity":"54df99bb-a5c3-47e2-a0b5-51788fc52b29","order_by":1,"name":"Ao Li","email":"","orcid":"","institution":"People's Hospital of Yuxi City, The Sixth Affiliated Hospital of Kunming Medical 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inflammation","lastPublishedDoi":"10.21203/rs.3.rs-6456847/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6456847/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThis study investigated the correlation between anemia and phosphorus metabolism in patients with nondialysis chronic kidney disease (CKD).\u003cstrong\u003e \u003c/strong\u003eA total of 196 patients with nondialysis CKD with complete clinical information who were hospitalized in the Department of Nephrology at the Sixth Affiliated Hospital of Kunming Medical University from November 2021 to June 2022 were enrolled. Among these patients, 119 had anemia (anemia group), and 77 did not have anemia (nonanemia group). Univariate logistic regression analysis was performed to analyze the effects of diabetes mellitus (DM), hypertension, and the levels of serum phosphorus, blood calcium, high-sensitivity C-reactive protein (Hs-CRP), and 24-h urinary electrolytes on anemia. Multivariate logistic regression analysis using backward stepwise selection was then performed to further analyze the effect of each factor on anemia. DM, hypertension, the levels of corrected calcium, serum phosphorus, intact parathyroid hormone (iPTH), Hs-CRP, and 24-h urinary phosphorus, and the fractional excretion of phosphorus (FePi) (all P\u003cem\u003e \u003c/em\u003e\u0026lt; 0.05) were correlated with the incidence of anemia in patients with CKD. Furthermore, there was a 5.82-fold increase, 0.12-fold decrease, and 0.04-fold increase in the risk of anemia for every 1-mmol/L increase in serum phosphorus (OR = 6.82, 95% CI: 1.32–35.11), 1-mmol/L increase in 24-h urinary phosphorus (OR = 0.88, 95% CI: 0.81–0.91), and 1-mg/dL increase in Hs-CRP (OR = 1.04, 95% CI: 1.01–1.07), respectively. The FePi and serum phosphorus and Hs-CRP levels were independent risk factors, and the 24-h urinary phosphorus level was an independent protective factor for anemia in patients with nondialysis CKD.\u003c/p\u003e","manuscriptTitle":"Correlation between anemia and phosphorus metabolism in patients with nondialysis chronic kidney disease","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-03-25 15:30:36","doi":"10.21203/rs.3.rs-6456847/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"8309f7a2-a82f-4fc7-90c8-8de042733b98","owner":[],"postedDate":"March 25th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":65065738,"name":"Health sciences/Nephrology/Kidney"},{"id":65065739,"name":"Health sciences/Nephrology/Kidney diseases"}],"tags":[],"updatedAt":"2026-04-16T07:58:23+00:00","versionOfRecord":[],"versionCreatedAt":"2026-03-25 15:30:36","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6456847","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6456847","identity":"rs-6456847","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}