Effectiveness of complex therapy for endometrioid ovarian cysts depending on the presence or absence of undifferentiated dysplasia of connective tissue

evaluation of effectiveness of complex therapy of endometrioid ovarian cysts depending on the availability of undifferentiated dysplasia of connective tissues.

and Мethods. Under our supervision there were 70 patients aged from 18 to 40 years, depending on the presence or absence of undifferentiated dysplasia of connective tissue they were divided into 2 groups: I study group consisted of 35 patients with endometrioid ovarian cysts, who wereidentified to have more than 6 external phenotypic traits of undifferentiated dysplasia of connective tissues, II a comparison group consisted of 35 patients with endometrioid ovarian cysts with 6 and less phenotypic traits of undifferentiated dysplasia of connective tissues. To externally establish the phenotype a modified phenotypic map was used, including 63 metric units [12]. Patients of the main group and comparison group did not differ in age, complaints, reproductive and somatic factors, gynecological pathologies and the state of endometriosis. All the patients had not received specific therapy of endometriosis before the surgery. All patients diagnosed for endometrioid ovarian cysts were confirmed histologically. for all the patients after a complete observation a laparoscopy was performed, followed by theremoval of cysts in healthy tissues, separation of adhesions, hydrotubation. After surgery the patient of both groups within 6 months received an agonist Gonadotropin releasing hormone «Buserelin- depot» («pharmsintez», Russia): intramuscularly in a dose of 3.75 mg once every 28 days for 6 months. For the comparative evaluation of the clinical effect of complex therapy for endometrioid ovarian cysts, the patients were observed and monitored the frequency of detection of pain syndrome, menstrual function, the level of CA-125 (through 1, 3, 6 and 12 months after completion of treatment), as well as infertility within 12 months after the treatment. In the absence of pregnancy after 12 months after completion of treatment, a second-look laparoscopy was performed to estimating the frequency of possible recurrence of endometrioid ovarian cysts. laparoscopy evaluated the state of organs of the pelvis area and abdomen, in case of endometriosis taking into account their size, color , location, extent, and depth of invasion, the severity of adhesions and patency of the fallopian tubes. After which a standard volume of operative Aleksanova Ekaterina, Assistant of obstetrics and gynecology department, Stavropol State Medical University; tel.: +79280069003; e-mail: [email protected] Aksenenko Victor, MD, PhD, Professor, Head of the obstetrics and gynecology department, Stavropol State Medical University; tel.: +78652716536 138138138 ORIGINAL RESEARCH Obstetrios and gynecology ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ Акушерство и гинекология138 interventions were conducted, depending on the extent of damage to the tissues. Statistical data processing was performed on a computer running PENTIUM IV with the use of the program «Statistica 6.0» [9]. In accordance with the purposes and objectives of the study, as well as taking into account the specifics of the analyzed variables the elementary statistics were solved with (mean values (M), medium errors (m), calculation of shares (%), standard error of the proportion (N)); comparison of the qualitative parameters in the groups studied with the help of non-parametrical

2, Fisher’s adjusted Yeats; comparison of quantitative indicators using the nonparametric criterion Mann — Whitney. The criterion for statistical validity of the obtained conclusions was p<0.05, as considered in conventional medicine.

and Discussion. Complaints on pain syndrome before the treatment were 100.0 % from all the patients, regardless of undifferentiated dysplasia of connective tissues. 1 month after treatment there were no complaints of pain syndrome. 3 months after the end of therapy in the primary group and in the comparison group pain syndrome was reported in 3 patients (8,6 ± 4.7 %). 6 months after completion of therapy in the main group the resumption of the pain syndrome was observed in 10 (28.6 ± 7.6 %) patients, and in the group without undifferentiated dysplasia of connective tissues – 6 patients (17.1 ± 6.4 %). After 12 months of monitoring, the number of patients with pain syndrome in the main group increased to 12 (34.3±8.0 %), and in the group of comparison – up to 8 (22.9±7.1 %) (Fig. 1). cases-by 8.6 ± 4.7 % patients in each group. After 12 months of monitoring, the number of patients with menstrual cycle in the main group was 4, and in the group of comparison was 3 patients (11.4±5.4 % and 8.6±4.7 %, respectively) (Fig. 2). Fig. 1. Dynamics of pain syndrome in patients with endometrioid ovarian cysts depending on the presence or absence of undifferentiated dysplasia of connective tissue one year after completion of therapy. Before starting therapy, the symptoms of menstrual function disorders were detected in 18 (51,48,4 %) patients of the main and 17 (48,68,4 %) patients in the comparison group 1 month after the end of therapy complaints of menstrual dysfunction in both groups were noted. 3 months after the treatment of various disorders of the menstrual cycle met in one patient in each group. At the end of 6 months after completion of therapy menstrual irregularities observed in a three The content of serum CA-125 blood above 35 IU/ ml was determined in 24 patients of main group and 22 patients in the comparison group (68.6 ± 8.3 % and 62.9 ± 8.2 %, respectively). 1 month after completion of treatment the level of CA-125 above 35 IU/ml was not registered in any group studied. 3 months after completion of treatment the increase in the concentration of CA-125 in peripheral blood were observed in 1 (2.9 ± 2.8 %) patient of the main group and 1 (2.9 ± 2.8 %) patient in the comparison group. 6 months after completion of therapy noted an increase in the concentration of CA-125 in 6 (17.1 ± 6.4 %) patients of main group and 3 (8.6 ± 4.7 %) patients in the comparison group. By the end of the year noted a growth in the number of patients with elevated CA-125 in the peripheral blood. Increase of CA-125 shown in 8 (22.9 ± 7.1 %) patients of main group and in 4 (11.4 ± 5.4 %) patients in the comparison group (Fig. 3). Fig. 2. Dynamics of menstrual disorders in patients with endometrioid ovarian cysts depending on the presence or absence of undifferentiated dysplasia of connective tissue one year after completion of therapy Fig. 3. Dynamics of the level of CA-125 in the peripheral blood of patients with endometrioid ovarian cysts depending on the presence or absence of undifferentiated dysplasia of connective tissue one year after completion of therapy МЕДИЦИНСКИЙ ВЕСТНИК СЕВЕРНОГО КАВКАЗА 2014. Т. 9. № 2 MEDICAL NEWS OF NORTH CAUCASUS 2014. Vоl. 9. Iss. 2 139139139139 Before the beginning of the treatment infertility was observed in 13 (37.1±8.2 %) patients of main group and 12 (34.3±8.0 %) patients in the comparison group. 3 months after completing therapy pregnancy occurred in 2 patients with infertility in the group of comparison and 1 patients of the main group (16.7±10.8 % and 7.7 ± 7.4 %, respectively). After 6 months after completion of therapy pregnancy occurred in 5 (41.7 ± 14.2 %) patients in the comparison group and 4 (30.8 ± 12.8 %) patients of the main group. After 12 months pregnancy reporteded in 7 (58.3 ± 14.2 %) patients without undifferentiated dysplasia of connective tissue and 5 (38.5 ± 13.5 %) patients with undifferentiated dysplasia of connective tissue (Fig. 4). In case of recurrence of disease, foci of endometriosis were localized on the peritoneum sacroiliac ligaments and in the ovaries, and less frequently localized in the retro-peritoneum space and broad uterine ligaments. Identified relapses of endometrioid ovarian cyst shad not exceed the diameter of 3 cm and were always unilateral. It should be noted that the localization of foci of endometriosis is not dependant on the presence or absence of undifferentiated dysplasia of connective tissue. When performed a re-laparoscopy presence of an adhesive process was detected in 15 (42.9±8.4 %) patients of main group and in 10 (28.6±7.4 %) patients in the comparison group. Conclusion. Summarizing the data obtained, it can be argued that while conducting the same complex therapy for endometrioid ovarian cysts with the presence of undifferentiated dysplasia of connective tissue, return rate of the pain syndrome after treatment is 1.5 times higher than in the comparison group (34.3±8.0 and 22.9±7.1 % of patients, respectively). A similar pattern was seen in the study of the content of serum CA-125 blood: increase of more than 35 IU/ml a year after completion of treatment is 2 times more frequently observed in patients with undifferentiated dysplasia of connective tissue than in patients in the comparison group (22.9±7,1 % and 11.4±5.4 % of patients, respectively). At the same time, studying the frequency of pregnancy in women with endometrioid ovarian cysts, it was found that when the number of phenotypic traits ofundifferentiated dysplasia of connective tissue were less than 6 the pregnancy rate was 1.4 times higher than in the patients with the phenotypic traits of undifferentiated dysplasia of connective tissue more than 6 (58.3±14.2 and 38.5±13.5 %). It should be noted that according to the laparoscopy, recurrence of external genital endometriosis was observed in almost one third of patient with endometrioid ovarian cysts. While in the group of patients with undifferentiated dysplasia of connective tissue endometriosis recurrence rate was 2 times higher than in patients without undifferentiated dysplasia of connective tissue (40.0±8,3 and 22.9±7.1 %, respectively), and the frequency of adhesion processesin the pelvic were 1.5 times (42.9±8.4 and 28.6±7.4 %, respectively). Fig. 4. Pregnancy rate in patients with infertility associated with endometrioid ovarian cysts depending on the presence or absence of undifferentiated dysplasia of connective tissue one year after completion of therapy In accordance with the developed research Protocol 12 months after completion of treatment of all non-pregnant women with endometrioid ovarian cysts, a second laparoscopy was performed (30 patients of main group and 28 patients of comparison group). When performed a re-laparoscopy foci of endometriosis in the pelvic peritoneum or ovaries were found in 14 patients with undifferentiated dysplasia of connective tissue (40.0 ± 8.3 %) and 7 (20.0 ± 7.1 %) patients without undifferentiated dysplasia of connective tissue.

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ЭФФЕКТИВНОСТЬ КОМПЛЕКСНОЙ ТЕРАПИИ ЭНДОМЕТРИОИДНЫХ КИСТ ЯИЧНИКОВ В ЗАВИСИМОСТИ ОТ НАЛИЧИЯ НЕДИФФЕРЕНЦИРОВАННОЙ ДИСПЛАЗИИ СОЕДИНИТЕЛЬНОЙ ТКАНИ Е. М. АЛЕКСАНОВА, В. А. АКСЕНЕНКО Проведена оценка эффективности ком - плексной терапии эндометриоидных кист яич- ников в зависимости от наличия недифферен - цированной дисплазии соединительной ткани. Установлено, что при проведении одинаковой терапии частота возврата болевого синдрома после завершения лечения в 1,5 раза выше у пациенток с эндометриозными кистами яични- ков (ЭКЯ) при наличии недифференцирован - ной дисплазии соединительной ткани (НДСТ), чем у женщин без признаков НДСТ . Повышение уровня СА-125 в сыворотке крови спустя год по - сле завершения лечения наблюдалось в 2 раза чаще у пациенток с НДСТ , чем у больных группы сравнения. 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Intraobserver and interobserver reliability of videotaped laparoscopy evaluations for endometriosis and adhesions. Fertil. Steril . 2007;87(2):373-380. EFFECTIVENESS OF COMPLEX THERAPY FOR ENDOMETRIOID OVARIAN CYSTS DEPENDING ON THE PRESENCE OR ABSENCE OF UNDIFFERENTIATED DYSPLASIA OF CONNECTIVE TISSUE ALEKSANOVA E. M., AKSENENKO V. A. It is established, that by carrying out the same therapy the frequency of pain syndrome returning after treatment is 1.5 times higher in patients with undifferentiated dysplasia of connective tissue than women without evidence of undifferentiated dysplasia of connective tissue. Increase in the le- vel of CA-125 in blood serum, a year after the end of treatment was observed to be 2 times more fre - quent in patients with undifferentiated dysplasia of connective tissue than the patients in the com - parison group. At the same time, studying the fre - quency of pregnancy in women with endometrioid ovarian cysts, it was found that when the number of phenotypic traits of undifferentiated dysplasia of connective tissue were less than 6 the pregnancy rate was 1.4 times higher than in the patients with the phenotypic traits of undifferentiated dysplasia of connective tissue more than 6. In the group of patients with undifferentiated dysplasia of connec - tive tissue frequency of adhesion processes in the pelvic was– 1.5 times higher and endometriosis re - currence rate was 2 times higher than in patients without undifferentiated dysplasia of connective tissue. Key words: endometrioid ovarian cysts, dyspla - sia of connective tissue, endometriosis