A novel encryption scheme for secure communication based on RNA

A novel encryption scheme for secure communication based on RNA | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A novel encryption scheme for secure communication based on RNA Durr Mhammad, Muhammad Aoun, Muhammad Asgher Nadeem, Muhammad Usman Younus This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3021941/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 4 You are reading this latest preprint version Abstract Design of RNA-based encryption schemes such as speed, security, and scalability utilize RNA molecules to encrypt and decrypt images in recent years. RNA-based encryption schemes have been proposed as a potential solution for secure communication. RNA molecules are used to encrypt messages, and the encrypted message can only be decoded using a complementary RNA sequence. In this paper, we propose a novel RNA-based encryption scheme that uses pixel depth to encode the RNA sequence. Our method employs the property of RNA sequences that their complementary sequences fold into specific shapes and assign each nucleotide in the RNA sequence a pixel value based on its location in the folded structure, and then use the pixel depth of these values to encode the message. We also demonstrate the effectiveness of the proposed method by encrypting and decrypting messages of varying length and complexity. Our approach is resistant to attacks based on frequency analysis, and it has potential applications in secure communication systems. RNA encryption Pixel-based encryption Pixel cryptography Genetic encryption Information security RNA sequencing Full Text Cite Share Download PDF Status: Under Review Version 1 posted Reviewers agreed at journal 31 Jul, 2023 Reviewers invited by journal 30 Jul, 2023 Editor assigned by journal 09 Jun, 2023 First submitted to journal 04 Jun, 2023 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3021941","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":222685590,"identity":"c6c00267-c7e5-4def-b1af-feb3145401e9","order_by":0,"name":"Durr Mhammad","email":"","orcid":"","institution":"MUET: Mehran University of Engineering \u0026 Technology","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Durr","middleName":"","lastName":"Mhammad","suffix":""},{"id":222685591,"identity":"2ee8873b-b38c-4080-a01c-fceff8accf9b","order_by":1,"name":"Muhammad Aoun","email":"","orcid":"","institution":"Ghazi University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Muhammad","middleName":"","lastName":"Aoun","suffix":""},{"id":222685592,"identity":"b40f4ad4-0a03-4a8c-83a5-159813c56103","order_by":2,"name":"Muhammad Asgher Nadeem","email":"","orcid":"","institution":"University of Sargodha","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Muhammad","middleName":"Asgher","lastName":"Nadeem","suffix":""},{"id":222685593,"identity":"9e1fd719-7723-40d2-b677-9f2b393022ae","order_by":3,"name":"Muhammad Usman Younus","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA2ElEQVRIiWNgGAWjYNACAxtmxvYGEMOCWC0FaezMPQdAWiSI1fLhED/7jAQQiwgtBudPJ34uMDggzTvz+dUNPwokGPjbuxPwa7mRu1l6hsEdY8nZOWU3e4AOkzhzdgMBLbwbpHkMniUbzs5Ju8ED1GIgkUtAy/mzm3/zGByu33/zTNrNP0RpOZC7DWjLYWbGGezHbhNli+SN3G3WPAZpzIw9OWy3ZQwkeAj6hQ/osNs8f0BRefzZzTd/bOT423vxa0ECPAZgkljlIMD+gBTVo2AUjIJRMIIAAAIySgiRu5jBAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0001-9033-1767","institution":"Universite Federale Toulouse Midi-Pyrenees Ecole Doctorale Mathematiques Informatique Telecommunications de Toulouse","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Muhammad","middleName":"Usman","lastName":"Younus","suffix":""}],"badges":[],"createdAt":"2023-06-05 00:40:00","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3021941/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3021941/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":41042525,"identity":"3df27531-e917-4078-afea-80e46d04ba9a","added_by":"auto","created_at":"2023-08-03 22:32:59","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":416625,"visible":true,"origin":"","legend":"","description":"","filename":"FinalDraf.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3021941/v1_covered_4efa3432-e273-4b43-b38d-afe10c5c5b74.pdf"}],"financialInterests":"","formattedTitle":"A novel encryption scheme for secure communication based on RNA","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"wireless-personal-communications","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"wire","sideBox":"Learn more about [Wireless Personal Communications](https://www.springer.com/journal/11277)","snPcode":"11277","submissionUrl":"https://submission.nature.com/new-submission/11277/3","title":"Wireless Personal Communications","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"RNA encryption, Pixel-based encryption, Pixel cryptography, Genetic encryption, Information security, RNA sequencing","lastPublishedDoi":"10.21203/rs.3.rs-3021941/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3021941/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eDesign of RNA-based encryption schemes such as speed, security, and scalability utilize RNA molecules to encrypt and decrypt images in recent years. 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