Synthesis and Characterization of MoS 2 Nanoflowers Decorated Amino Cellulose Derivatives: An Innovative Approach for Anticancer Therapeutics

Microcrystalline cellulose (MCC) was modified to amino cellulose (AC) derivatives, 6-deoxy-6-hydrazide cellulose, 6-deoxy-6-(N, N-diethyl) amine cellulose, and 6-deoxy-6-diethyltriamine cellulose (C-Hyd, C-DEA, and C-DETA). AC’s were used as supporting material for the MoS 2 Nanoflowers (NFs) for the development of nanocomposites as cancer therapeutics. ACs-MoS 2 nanocomposites were analyzed by using spectroscopy, X-ray diffraction (XRD), Scanning Electron Microscopy (SEM)-EXS, and Zeta potential. MoS 2 NF loading, swelling, and degradation rate of ACs-MoS 2 nanocomposites have been investigated. ACs-MoS 2 nanocomposites were analyzed against four cancer cell lines NIH3T3, B16F10, MDA-MB-231, and MCF-7 cell lines by using presto blue and LIVE/DEAD staining. Cell viability assay and fluorescence microscopy against four cell lines revealed that all AC’s-MoS 2 nanocomposites with 5wt% MoS 2 showed selective cytotoxicity for cancer cell lines as compared to normal fibroblast cell lines. Our findings revealed that amino cellulose derivatives loaded with MoS 2 could be efficient candidates for skin and breast cancer therapy.