Glucose-6-Phosphate Dehydrogenase Activity in the Endometrium and Myometrium of the Rat Uterus During the Estrous Cycle and Progestation

Gerald J. Pepe, J. M. Yochim
In: Biology of Reproduction · 1971 · vol. 5(2) , pp. 161–171 · doi:10.1093/biolreprod/5.2.161 · PMID:5118640 · W2183348685
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Abstract

Measurements of glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconic acid dehydrogenase (6PGADH), protein (soluble and insoluble), and nucleic acids were made in endometrium and myometrium of the uterus of the rat during the estrous cycle, early pseudopregnancy, and following decidual induction. During the follicular phase of the estrous cycle, a period of increased hyperplasia and increased synthetic activity in the endometrium, G6PDH, 6PGADH, RNA, DNA, and protein were increased. Little change occurred in myometrium. Immediately following the induction of pseudopregnancy, a decrease in enzyme activity, protein, and RNA content occurred, but total DNA did not decline as rapidly; the data indicate that the endometrium was subjected to an alteration in hormone balance sufficient to cause a degree of cytoplasmic regression, but not much cell death. During Days 1–4 of pseudopregnancy a gradual reversal of these regressive changes was measured; however, increased G6PDH and 6PGADH were not required to support this process, and in fact the specific activity of these enzymes was depressed. Induction of decidualization on Day 4 of pseudopregnancy did not affect the specific activity of G6PDH and 6PGADH on Days 5, 7, or 9. Thus, increased enzyme activity was not required to support either the gradual differentiational process preceding the time of decidual sensitivity, or the rapid hyperplasia and differentiation of the endometrium observed following decidual induction. The relationship between G6PDH activity and metabolism through the hexose monophosphate pathway during pseudopregnancy is discussed.

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