Analgesic and OHRQoL Outcomes of 650 nm vs 810 nm Diode Laser Photobiomodulation After Dental Implant Placement: A Randomized Controlled Trial

Analgesic and OHRQoL Outcomes of 650 nm vs 810 nm Diode Laser Photobiomodulation After Dental Implant Placement: A Randomized Controlled Trial | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Analgesic and OHRQoL Outcomes of 650 nm vs 810 nm Diode Laser Photobiomodulation After Dental Implant Placement: A Randomized Controlled Trial Mohammad M. Y. Abdussalam, Zein Z. A. Adham, Reema Saeed-ur-Rahman, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6858207/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 21 Apr, 2026 Read the published version in Scientific Reports → Version 1 posted You are reading this latest preprint version Abstract Photobiomodulation (PBM) is a promising non-pharmacological approach for managing postoperative pain after dental im-plant placement, yet comparative data on red (650 nm) and near-infrared (810 nm) diode lasers remain limited and inconclu-sive. This double-blind, randomized controlled trial evaluated the short-term analgesic efficacy of 650 nm and 810 nm PBMon postoperative pain, analgesic intake, and oral health-related quality of life (OHRQoL) following single-implant placementin the posterior maxilla. Sixty patients were randomly assigned to receive PBM with 650 nm, PBM with 810 nm, or a shamcontrol. Laser therapy (18 J total energy) was administered immediately postoperatively and again at 48 hours. Pain intensity(11-point Numeric Rating Scale) and analgesic use were recorded at 2, 6, 12, 24, 48, and 72 hours post-surgery. OHRQoLwas assessed using the OHIP-14 questionnaire at baseline, one week, and after crown delivery. At 2 hours, both PBM groupsreported significantly lower pain scores compared to the sham group (p < 0.05), with no severe pain observed in the PBMgroups. The 650 nm group exhibited significantly reduced analgesic consumption at 2 and 6 hours (p < 0.05), indicating supe-rior early analgesic effect. Pain scores and medication use converged across groups after 12 hours. While overall OHRQoLscores did not differ significantly, the 810 nm group showed improvement in the physical disability domain. These resultssuggest that PBM with both wavelengths alleviates acute postoperative pain, with the 650 nm laser offering enhanced short-term pain control. PBM, particularly at 650 nm, may serve as an effective adjunct to improve early postoperative outcomes inminimally invasive implant procedures. Trial registration: The study is retrospectively registered at ClinicalTrials.gov (https://clinicaltrials.gov/study/NCT06988722; Identifier: NCT06988722, registered on 25/05/2025). Biological sciences/Biophysics Health sciences/Medical research Health sciences/Signs and symptoms Full Text Additional Declarations No competing interests reported. Supplementary Files suppfile1.pdf suppfile2.pdf suppfile3.pdf Cite Share Download PDF Status: Published Journal Publication published 21 Apr, 2026 Read the published version in Scientific Reports → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6858207","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":483614750,"identity":"2d839e70-b464-4138-9740-5a5ab44b9ddf","order_by":0,"name":"Mohammad M. Y. Abdussalam","email":"","orcid":"","institution":"Cairo University","correspondingAuthor":false,"prefix":"","firstName":"Mohammad","middleName":"M. Y.","lastName":"Abdussalam","suffix":""},{"id":483614751,"identity":"e804cf60-f721-4856-bbdf-8770fad48167","order_by":1,"name":"Zein Z. A. 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This double-blind, randomized controlled trial evaluated the short-term analgesic efficacy of 650 nm and 810 nm PBMon postoperative pain, analgesic intake, and oral health-related quality of life (OHRQoL) following single-implant placementin the posterior maxilla. Sixty patients were randomly assigned to receive PBM with 650 nm, PBM with 810 nm, or a shamcontrol. Laser therapy (18 J total energy) was administered immediately postoperatively and again at 48 hours. Pain intensity(11-point Numeric Rating Scale) and analgesic use were recorded at 2, 6, 12, 24, 48, and 72 hours post-surgery. OHRQoLwas assessed using the OHIP-14 questionnaire at baseline, one week, and after crown delivery. At 2 hours, both PBM groupsreported significantly lower pain scores compared to the sham group (p \u0026lt; 0.05), with no severe pain observed in the PBMgroups. The 650 nm group exhibited significantly reduced analgesic consumption at 2 and 6 hours (p \u0026lt; 0.05), indicating supe-rior early analgesic effect. Pain scores and medication use converged across groups after 12 hours. While overall OHRQoLscores did not differ significantly, the 810 nm group showed improvement in the physical disability domain. These resultssuggest that PBM with both wavelengths alleviates acute postoperative pain, with the 650 nm laser offering enhanced short-term pain control. PBM, particularly at 650 nm, may serve as an effective adjunct to improve early postoperative outcomes inminimally invasive implant procedures.\u003c/p\u003e\n\u003cp\u003eTrial registration: The study is retrospectively registered at ClinicalTrials.gov (https://clinicaltrials.gov/study/NCT06988722; Identifier: NCT06988722, registered on 25/05/2025).\u003c/p\u003e","manuscriptTitle":"Analgesic and OHRQoL Outcomes of 650 nm vs 810 nm Diode Laser Photobiomodulation After Dental Implant Placement: A Randomized Controlled Trial","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-07-18 07:36:51","doi":"10.21203/rs.3.rs-6858207/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"da8dadf3-05bd-4a39-9aae-2f5864f66b5f","owner":[],"postedDate":"July 18th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":51351235,"name":"Biological sciences/Biophysics"},{"id":51351236,"name":"Health sciences/Medical research"},{"id":51351237,"name":"Health sciences/Signs and symptoms"}],"tags":[],"updatedAt":"2026-04-27T16:03:46+00:00","versionOfRecord":{"articleIdentity":"rs-6858207","link":"https://doi.org/10.1038/s41598-025-32248-8","journal":{"identity":"scientific-reports","isVorOnly":false,"title":"Scientific Reports"},"publishedOn":"2026-04-21 15:59:04","publishedOnDateReadable":"April 21st, 2026"},"versionCreatedAt":"2025-07-18 07:36:51","video":"","vorDoi":"10.1038/s41598-025-32248-8","vorDoiUrl":"https://doi.org/10.1038/s41598-025-32248-8","workflowStages":[]},"version":"v1","identity":"rs-6858207","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6858207","identity":"rs-6858207","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}