Bio-based pH‐responsive nanofibrous membranes for controlled release of tetracycline hydrochloride

Design: and fabrication of pH-responsive nanofibrous membranes by biomaterials is a key step for drug delivery systems. Currently, there is an increasing attention on design of biocompatible nanofibrous drug delivery systems. Here, a bio-based pH‐responsive nanofibrous membranes loaded with antibiotic were fabricated for the controlled release of tetracycline hydrochloride (TH). The in vitro drug release behavior of varied pH‐responsive nanofibrous with different mass ratios of poly (lactic acid) and cellulose acetate phthalate was investigated to clarify the release mechanism. The prepared fibrous membranes possess sufficient antibacterial activity against both to Gram-negative and Gram-positive bacteria. At the same time, it also has good biocompatibility. Therefore, the fabricated nanofibrous membranes was demonstrated to be a pH-responsive nanoplatform for drug delivery, which may be serve as a novel antibacterial wound dressing.