The “Freeze-All” Strategy Seems to Improve the Chances of Birth in Adenomyosis-Affected Women

This retrospective cohort study evaluated the impact of a "freeze-all" strategy, which delays embryo transfer until after ovarian stimulation has subsided, on live birth rates in women with adenomyosis undergoing in vitro fertilization. The researchers compared outcomes between patients who underwent fresh embryo transfers and those who had all embryos cryopreserved for subsequent frozen-thawed cycles, analyzing data from a large French university hospital center. The findings indicate that the freeze-all approach significantly improves the chances of achieving a live birth in this specific patient population, likely by allowing the uterine environment to recover from the inflammatory effects of hormonal stimulation. This paper is centrally about adenomyosis — specifically examining how delaying embryo transfer can mitigate the negative reproductive impacts associated with the condition during assisted reproduction treatments.

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