Androgen Administration in the Postmenopausal Woman

William H. Masters, DOROTHY T. MAGALLON
In: The Journal of Clinical Endocrinology & Metabolism · 1950 · vol. 10(3) , pp. 348–358 · doi:10.1210/jcem-10-3-348 · W2138996286
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This paper presents observations and discusses physiologic and histologic factors from administering estrogen and testosterone to postmenopausal women to explore androgen use in women.

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Abstract

DURING the past ten years the utilization of androgens as therapeutic agents in women has become increasingly popular. In a complete and objective survey of the subject Carter, Cohen, and Shorr (1) emphasize the fact that although recent literature is studded with accounts of beneficial results obtained by the administration of various androgenic preparations to women, actually very little is known of the pathophysiology involved. The purpose of this paper, then, is to present some interesting observations recorded as the result of the administration of estrogen and testosterone to a group of postmenopausal women and to discuss some of the physiologic and histologic factors which come into play when a basically male hormone is given to the human female. Most of the major contributions concerning androgens and their relationship to the other components of the female endocrine system have been too well reviewed in the above mentioned paper to warrant repetition here. Suffice it to say that despite the excellent work which has been done, many aspects of the influence of the male sex hormones on normal and abnormal menstrual cycles require further clarification.

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