Case Report: Solitary fibrous tumor of the eyelid in a child: a case report and review of the literature

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While these tumors are most found in the pleura, they can also present in extra-pleural sites, including the orbit, particularly in adults. Herein, we report a rare case of SFT of the eyelid in a pediatric patient and review the existing literature on similar cases. Methods A case of a 5-year-old male with a nodule on the eyelid margin is presented. The nodule was completely resected and histopathologically confirmed as SFT. A comprehensive review of the published cases of eyelid SFT was conducted. Results The case represents the second reported instance of eyelid SFT in a pediatric patient and is the youngest case documented to date. The tumor’s histopathological examination revealed characteristics consistent with SFT. The review of the literature identified only 10 cases of eyelid SFT in English literature, with just one previously reported in the pediatric population. Conclusion SFT of the eyelid is extremely rare, especially in pediatric patients. Despite its rarity, SFT should be considered in the differential diagnosis of vascular spindle-cell tumors of the eyelid in this age group. Early recognition and complete resection are crucial for effective management. " } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/14-304/v1", "name": "Case Report: Solitary fibrous tumor of the eyelid in a child: a case..." } } ] } Home Browse Case Report: Solitary fibrous tumor of the eyelid in a child: a case... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Chowdary B T, Desai A, B Madhuri K et al. Case Report: Solitary fibrous tumor of the eyelid in a child: a case report and review of the literature [version 1; peer review: 1 approved with reservations] . F1000Research 2025, 14 :304 ( https://doi.org/10.12688/f1000research.159602.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Case Report Case Report: Solitary fibrous tumor of the eyelid in a child: a case report and review of the literature [version 1; peer review: 1 approved with reservations] Tharuni Chowdary B 1 , Akruti Desai https://orcid.org/0000-0002-8717-5481 2 , Kavya B Madhuri 1 , Dilip Mishra 3 , Anasua Ganguly Kapoor 1 Tharuni Chowdary B 1 , Akruti Desai https://orcid.org/0000-0002-8717-5481 2 , [...] Kavya B Madhuri 1 , Dilip Mishra 3 , Anasua Ganguly Kapoor 1 PUBLISHED 17 Mar 2025 Author details Author details 1 Ophthalmic plastic surgery & Ocular oncology services, Hima Bindu Yalamanchili Centre for eye cancer The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Vijayawada, India 2 Ophthalmic Plastic Surgery, Eye Cancer & Aesthetics services, Shantilal Shanghvi Eye Institute, Mumbai, Maharashtra, India 3 Consultant pathologist, LV Prasad Eye Institute, Vijayawada, India Tharuni Chowdary B Roles: Data Curation, Writing – Original Draft Preparation Akruti Desai Roles: Writing – Review & Editing Kavya B Madhuri Roles: Writing – Review & Editing Dilip Mishra Roles: Data Curation, Writing – Review & Editing Anasua Ganguly Kapoor Roles: Conceptualization, Data Curation, Resources, Software, Supervision, Validation, Writing – Original Draft Preparation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Oncology gateway. This article is included in the Eye Health gateway. Abstract Introduction Solitary fibrous tumors (SFT) are typically characterized by the proliferation of CD34-positive specialized fibroblasts. While these tumors are most found in the pleura, they can also present in extra-pleural sites, including the orbit, particularly in adults. Herein, we report a rare case of SFT of the eyelid in a pediatric patient and review the existing literature on similar cases. Methods A case of a 5-year-old male with a nodule on the eyelid margin is presented. The nodule was completely resected and histopathologically confirmed as SFT. A comprehensive review of the published cases of eyelid SFT was conducted. Results The case represents the second reported instance of eyelid SFT in a pediatric patient and is the youngest case documented to date. The tumor’s histopathological examination revealed characteristics consistent with SFT. The review of the literature identified only 10 cases of eyelid SFT in English literature, with just one previously reported in the pediatric population. Conclusion SFT of the eyelid is extremely rare, especially in pediatric patients. Despite its rarity, SFT should be considered in the differential diagnosis of vascular spindle-cell tumors of the eyelid in this age group. Early recognition and complete resection are crucial for effective management. READ ALL READ LESS Keywords Solitary fibrous tumour, Eyelid, Children, Pediatric, eye tumor Corresponding Author(s) Anasua Ganguly Kapoor ( [email protected] ) Close Corresponding author: Anasua Ganguly Kapoor Competing interests: No competing interests were disclosed. Grant information: This study has been supported by Hyderabad Eye Research Foundation, LV Prasad Eye Institute, India. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Copyright: © 2025 Chowdary B T et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Chowdary B T, Desai A, B Madhuri K et al. Case Report: Solitary fibrous tumor of the eyelid in a child: a case report and review of the literature [version 1; peer review: 1 approved with reservations] . F1000Research 2025, 14 :304 ( https://doi.org/10.12688/f1000research.159602.1 ) First published: 17 Mar 2025, 14 :304 ( https://doi.org/10.12688/f1000research.159602.1 ) Latest published: 17 Mar 2025, 14 :304 ( https://doi.org/10.12688/f1000research.159602.1 ) Introduction Solitary fibrous tumors (SFTs) are a special group of spindle cell tumors of mesenchymal origin. They were first reported in the pleura by Klemperer and Rabin in 1931. 1 It seldom involves extra-pleural sites such as the lung, pericardium, liver, kidney, parotid, thyroid gland, peritoneum, nasal cavity, and orbit. In 1994 Dorfman et al. and Westra et al. first elucidated SFT of the orbit. 1 They have also been reported in the lacrimal drainage system with their specific characteristics and tailored surgical managements. 2 Eyelid involvement is extremely rare, and to the best of author’s knowledge, only 10 cases exist in the English literature out of which only one was reported in the paediatric age group. 3 , 4 Cellularity of SFT varies, with frequent hypocellular areas rich in collagen, and the stroma is myxoid. SFT has a prominent vasculature with dilated blood vessels similar to hemangiopericytoma. Characteristically, the tumour cells exhibit immunoreactivity for CD34 (human hematopoietic progenitor cell antigen) and vimentin (a marker of mesenchymal elements). 5 The highly vascular nature of the tumour and tendency for bleeding at surgery suggest special precautions and care in their surgical removal. Complete excision with blunt dissection is recommended whereever possible. Careful and long-term follow-up is important and necessary because the tumour may recur locally several years after excision of the primary tumor. 5 Herein, we report successful outcome in a rare case of eyelid SFT in a 5-years-old-child managed with surgical excision in toto along with a review of all the paediatric cases of eyelid and orbit SFT reported in literature. Patient consent has been obtained for publishing identifiable photographs. The case report adhered to the ethical principles outlined in the Declaration of Helsinki as amended in 2013 and also HIPAA compliant. Case report A 5-years-old boy presented with a gradually progressive painless nodule over the temporal aspect of the left lower eyelid of three months duration. External examination revealed a temporal, firm, bilobed subcutaneous well-circumscribed marginal nodule measuring 11×12×6 mm in lower eyelid ( Figures 1A , 1B ). There was mild hyperpigmentation of the overlying skin with no associated lash loss or posterior lamellar involvement. The nodule was excised in toto through a sub ciliary skin incision. Gross examination showed it to be a well-capsulated globular white mass ( Figure 1C ). Histopathology showed fragments of tissue had spindle cells with indistinct cell border and few of the spindle cells also showed long cytoplasmic processes. These spindle cells were arranged in loose clusters and ill-defined fascicles in the background of entrapped small blood vessels, myxoid degeneration and thick hyalinized collagen bundles. Few admixed mast cells, multinucleated and scattered chronic inflammatory cells were also noted. These spindle cells showed intense positive immunoreactivity for CD34, STAT-6 and negative immunoreactivity for smooth muscle actin (SMA) compatible with diagnosis of solitary fibrous tumour eyelid ( Figures 2A to 2D ). The patient is tumour free at 2 year follow up ( Figure 1D ). Figure 1. A, B. Clinical photograph showing a temporal, firm, bilobed subcutaneous well-circumscribed marginal nodule measuring 11×12×6 mm in lower eyelid with overlying mild hyperpigmentation of the skin; C. Gross examination showed it to be a well-capsulated globular white mass; D. The patient is tumour free at 2 year follow up. Figure 2. A. Photomicrograph showed spindle shaped tumor cells arranged in loose clusters and ill-defined fascicles in the background of myxoid degeneration and collagen bundles; Haematoxylin & Eosin (H&E) stain, ×200; B. Photomicrograph showed spindle cells were positive for immunostaining STAT-6, ×200; C. Photomicrograph showed spindle cells are negative for immunostaining SMA, ×200; D. Photomicrograph showed spindle cells were positive for immunostaining CD34, ×200. Discussion Solitary fibrous tumor (SFTs) is amongst a group of rare tumors composed of proliferating CD34- positive specialized fibroblasts. Because of overlapping morphologic and immunohistochemical features the term solitary fibrous tumor is used as an encompassing terminology for the entities like SFT, hemangiopericytoma, giant cell angiofibroma and fibrous histiocytoma. 6 They most often arise from the pleura but may also occur in multiple locations as well, such as the lungs, peritoneum, pericardium, kidneys, liver, thyroid, parotid, adrenal gland, breast, genito-urinary tract, and meninges. Although the superior orbit is the most frequently reported location for periocular SFTs, it may also occur in the intraconal space, sclera, lacrimal sac, conjunctiva, lacrimal gland fossa, and eyelids. 1 – 3 Herein, we describe an isolated case of SFT of the eyelid, which has rarely been reported in the literature. SFTs are predominantly benign tumors, but there are reported cases of residual tumors, recurrence, and malignant transformation. The treatment of choice is complete resection, as incomplete excision significantly increases the risk of recurrence and malignant conversion. However, achieving clear margins can be challenging due to the tumor’s fragile capsule, high vascularity, which poses a significant risk of intraoperative hemorrhage, and poor cohesiveness. On histopathological examination, the eyelid mass in this patient was compatible with SFT. Nevertheless, to corroborate the diagnosis, CD34 immunotyping of the neoplastic cells was carried out in light of the peculiar location. The tumor in this case was immunoreactive for vimentin and STAT-6 in addition to CD34, as was previously observed in tumors of a similar nature. Before the widespread use of immunohistochemical research and CD34 labelling, the diagnosis of orbital and periorbital SFT was frequently confounded with other benign tumors such as meningioma, schwannoma, and fibromatosis. 7 A hypercellular and hypocellular zone of spindle cells with no specific pattern can be seen in a solitary fibrous tumor against a backdrop of dense collagen bands. Mesenchymal markers like Vimentin are positive in solitary fibrous tumors; however, desmin, cytokeratin, factor VIII-related antigen (a vascular marker), S-100 protein (a neural marker), smooth muscle actin, and muscle-specific actin are negative. In 79–100% of instances, there is immunoreactivity to the marker CD34. Vimentin and CD34-uniform positivity support the diagnosis of SFT. Solitary fibrous tumors generally behave in a benign manner and do not metastasize. Malignancy is defined by having more than four mitoses per high-power field or having abnormal mitotic figures, as well as having cellular pleomorphism or tumor giant cells. Recurrent SFT is more aggressive and has higher mitotic activity than the original tumor. 6 – 10 Solitary fibrous tumors (SFT) of the eyelids are exceedingly rare. To date, only ten additional cases within the HPC-SFT-GCA spectrum have been reported in the literature ( Table 1 ). 8 – 14 Among these, only one case involved a pediatric patient. Our case involves a 5-year-old patient with an isolated eyelid SFT, making him the youngest documented patient with this condition. The mean age of reported cases is 38 years (median: 35; range: 5 to 78 years), and the mean duration of symptoms is 21 months (median: 12; range: 3-96 months). The majority of these patients are male (6 out of 8, 75%) where gender was specified. The upper and lower eyelids were equally affected in reported cases. Most isolated eyelid SFTs presented as slowly progressive, well-defined subcutaneous eyelid nodules. All patients demonstrated immunoreactivity to CD34. At an average follow-up of 30 months (median: 24; range: 6-96 months), 77% (7 out of 9) of patients were disease-free, while 2 lost to follow-up. One patient with tuberous sclerosis had all four eyelids involved, presenting with pedunculated eyelid lesions of giant cell angiofibroma and experienced multiple recurrences. Table 1. Review of cases of isolated solitary fibrous tumor of eyelid reported in English literature. S.No Author Year Age (years)/Sex Duration (Months) Morphology & Location Management Histopathology Follow up 1 Sekundo W e t al. 8 1996 31/F 3 Left medial canthus Tumour was excised Mesenchymal tumour consisting of densely packed oval-shaped and spindle-shaped cells growing haphazardly around sinusoidal vascular channels. The latter were lined by a single endothelial layer and showed in part a typical staghorn pattern 8 months follow-up with no recurrence 2 Hayashi N e t al. 9 1999 78/F 96 Nodular lesion at the medial aspect of the left upper lid At the patient’s insistence, only an incision biopsy was performed Pattern less, spindle-cell proliferation with a moderate to high degree of cellularity with numerous blood vessels CD34 and vimentin positive Lost to follow up 3 Mawn L e t al. 10 1999 30/M 24-36 Large pedunculated mass involving all four eyelid in a patient with tuberous sclerosis Resected twice Fibromyxoid lesion involving the dermis and subcutaneous tissue, scattered floret cellsCD34+, Bcl-2+ (HP- Giant cell angiofibroma). SMA and S-100 negative Follow up for 8 months, multiple recurrences 4 Song A e t al. 11 2005 24/M 12 Right painless subcutaneous nodule medial lower eyelid with predominant lobulated inferior forniceal conjunctival component Excision biopsy Tumor demonstrated numerous capillary-sized blood vessels with several tumor giant cells, and loosely arranged tumor cells corresponding to the angiectoid, or pseudovascular spaces. Focal areas containing wavy bundles resembling neural tissue (S100+) seen within the tumor (Giant cell angiofibroma) CD34+, Vimentin +, Bcl-2+ 8 months follow-up with no recurrence 5 Kim HJ e t al. 12 2008 40/M 6 Right lower eyelid nodular well defined mass CT- Isodense homogeneous contrast enhancement Complete excision of the tumour Pattern less arrangement of alternating hypercellular and hypocellular regions of spindle cells against a collagenous background of variable vascularity CD34+ 24 months follow-up with no recurrence 6 Kakizaki H et al. 13 2010 35/M 12 Slow growing painless hard immobile right lower eyelid mass with ectropion and telangiectasia and ulceration, bleed and crusting (history of recent rapid increase+) Total tumour excision and lateral tarsal strip Spindle cells arranged in short, ill-defined fascicles, set against a rich reticulin mesh. CD34 and Vimentin positive (HPC- SFT intermediate) 6 months follow-up with no recurrence 7 Irene Pecorella e t al. 14 2014 78/M 12 Slow growing painless hard elastic left lower eyelid subcutaneous Total tumour excision. Moderately cellular tumour, composed of pattern less uniform, bland-looking bipolar spindle or oval cells with indistinct eosinophilic cytoplasm, in a heavily collagenized stroma. CD34+, Bcl-2+ 24 month follow-up with no recurrence 8 Blandamura S et al. 4 2014 50 NS Left upper eyelid Excisional biopsy was performed Alternating hypercellular and hypocellular areas. They were composed of an intimate mixture of well-formed, thick-walled, often branching vessels of variable size, with intervening proliferation of spindle to round cells, showing oval nuclei with finely dispersed chromatin CD34, CD99 and Bcl2 were diffusely positive 6 years follow-up with no recurrence 9 Blandamura S et al. 4 2014 37 NS Right upper eyelid Excisional biopsy and an year later primary excision was performed Alternating hypercellular and hypocellular areas. They were composed of an intimate mixture of well-formed, thick-walled, often branching vessels of variable size, with intervening proliferation of spindle to round cells, showing oval nuclei with finely dispersed chromatin CD34, CD99 and Bcl2 were diffusely positive In spite of the residual disease, the patient is alive and well after 8 years 10 Blandamura S et al. 4 2014 5 NS Left upper eyelid Excisional biopsy was performed after which patient lost follow-up Alternating hypercellular and hypocellular areas. They were composed of an intimate mixture of well-formed, thick-walled, often branching vessels of variable size, with intervening proliferation of spindle to round cells, showing oval nuclei with finely dispersed chromatin The giant cells were numerous and scattered throughout the lesions Lost to follow-up 11 Present case 2020 5/M 3 Left lower lid temporal firm, bilobed subcutaneous well-circumscribed marginal nodule with overlying mild hyperpigmentation of the skin Nodule was excised in toto through a sub ciliary skin incision Fragments of tissue with pseudo cystic spaces and surrounding stroma showed spindle cells having long cytoplasmic processes arranged in loose clusters. Background of spindle cells had fibro myxoid substance and hyalinized collagen bundles. CD34, vimentin and STAT-6 positive 24 months follow up with no recurrence To conclude, eyelid SFTs are rare neoplasms that typically present as slow-growing, well-defined subcutaneous nodules on the eyelid. They predominantly affect individuals in their third or fourth decade of life, with a higher incidence in males. The treatment of choice is complete surgical excision. Accurate diagnosis relies on histopathology combined with immunohistochemistry. It is crucial to be aware of this entity involving eyelids and consider in the differential diagnosis of vascular spindle-cell eyelid tumors in children. No data are associated with this article. Author contributions AGK has treated the patient. TC wrote the manuscript. KBM and AD was also involved in editing the manuscript. DM was involved in providing histopathology insights and editing the final manuscript. Consent to publish Written informed consent has been taken from the patient prior to submission of this manuscript. Data availability No data are associated with this article. Acknowledgement Dr. Javed Ali, Head, Govindram Seksaria Institute of Dacryology, LV Prasad Eye Institute, Hyderabad, India. References 1. Ali MJ, Honavar SG, Naik MN, et al. : Orbital solitary fibrous tumor: A clinicopathologic correlation and review of literature. Oman J. Ophthalmol. 2011; 4 : 147–149. PubMed Abstract | Publisher Full Text 2. Morawala A, Bothra N, Dendukuri G, et al. : Solitary Fibrous Tumors of the Lacrimal Drainage System With Variable Orbital and Sinonasal Extensions: Combined External and Endoscopic Surgical Approach. Ophthalmic Plast. Reconstr. Surg. 2020; 36 (4): 403–409. PubMed Abstract | Publisher Full Text 3. Pecorella I, Cruciani F, Russo V: A solitary fibrous tumour of the eyelid. Med. Princ. Pract. 2014; 23 : 170–173. PubMed Abstract | Publisher Full Text | Free Full Text 4. Blandamura S, Alaggio R, Bettini G, et al. : Four cases of solitary fibrous tumour of the eye and orbit: one with sarcomatous transformation after radiotherapy and one in a 5-year-old child’s eyelid. J. Clin. Pathol. 2014; 67 : 263–267. PubMed Abstract | Publisher Full Text 5. Lucci LM, Anderson RL, Harrie RP, et al. : Solitary fibrous tumor of the orbit in a child. Ophthalmic Plast. Reconstr. Surg. 2001; 17 : 369–373. PubMed Abstract | Publisher Full Text 6. Furusato E, Valenzuela IA, Fanburg-Smith JC, et al. : Orbital solitary fibrous tumor: encompassing terminology for hemangiopericytoma, giant cell angiofibroma, and fibrous histiocytoma of the orbit: reappraisal of 41 cases. Hum. Pathol. 2011; 42 (1): 120–128. PubMed Abstract | Publisher Full Text 7. Girnita L, Sahlin S, Orrego A, et al. : Malignant solitary fibrous tumour of the orbit. Acta Ophthalmol. 2009; 87 : 464–467. Publisher Full Text 8. Sekundo W, Roggenkamper P, Tschubel K, et al. : Hemangiopericytoma of the inner canthus. Am. J. Ophthalmol. 1996; 121 : 445–447. PubMed Abstract | Publisher Full Text 9. Hayashi N, Borodic G, Karesh JW, et al. : Giant cell angiofibroma of the orbit and eyelid. Ophthalmology. 1999; 106 : 1223–1229. PubMed Abstract | Publisher Full Text 10. Mawn L, Jordan D, Nerad J, et al. : Giant cell angiofibroma of the eyelids: an unusual presentation of tuberous sclerosis. Ophthalmic Surg. Lasers. 1999; 30 : 320–322. PubMed Abstract | Publisher Full Text 11. Song A, Syed N, Kirby PA, et al. : Giant cell angiofibroma of the ocular adnexae. Arch. Ophthalmol. 2005; 123 : 1438–1443. PubMed Abstract | Publisher Full Text 12. Kim HJ, Kim HJ, Kim YD, et al. : Solitary fibrous tumor of the orbit: CT and MR imaging findings. AJNR Am. J. Neuroradiol. 2008; 29 : 857–862. PubMed Abstract | Publisher Full Text | Free Full Text 13. Kakizaki H, Maden A, Türe M, et al. : Hemangiopericytoma-solitary fibrous tumor of the eyelid. Ophthalmic Plast. Reconstr. Surg. 2010; 26 : 46–48. PubMed Abstract | Publisher Full Text 14. Pecorella I, Cruciani F, Russo V: A solitary fibrous tumour of the eyelid. Med. Princ. Pract. 2014; 23 : 170–173. PubMed Abstract | Publisher Full Text | Free Full Text Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 17 Mar 2025 ADD YOUR COMMENT Comment Author details Author details 1 Ophthalmic plastic surgery & Ocular oncology services, Hima Bindu Yalamanchili Centre for eye cancer The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Vijayawada, India 2 Ophthalmic Plastic Surgery, Eye Cancer & Aesthetics services, Shantilal Shanghvi Eye Institute, Mumbai, Maharashtra, India 3 Consultant pathologist, LV Prasad Eye Institute, Vijayawada, India Tharuni Chowdary B Roles: Data Curation, Writing – Original Draft Preparation Akruti Desai Roles: Writing – Review & Editing Kavya B Madhuri Roles: Writing – Review & Editing Dilip Mishra Roles: Data Curation, Writing – Review & Editing Anasua Ganguly Kapoor Roles: Conceptualization, Data Curation, Resources, Software, Supervision, Validation, Writing – Original Draft Preparation, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information This study has been supported by Hyderabad Eye Research Foundation, LV Prasad Eye Institute, India. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Article Versions (1) version 1 Published: 17 Mar 2025, 14:304 https://doi.org/10.12688/f1000research.159602.1 Copyright © 2025 Chowdary B T et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Chowdary B T, Desai A, B Madhuri K et al. Case Report: Solitary fibrous tumor of the eyelid in a child: a case report and review of the literature [version 1; peer review: 1 approved with reservations] . F1000Research 2025, 14 :304 ( https://doi.org/10.12688/f1000research.159602.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 1 VERSION 1 PUBLISHED 17 Mar 2025 Views 0 Cite How to cite this report: Gündüz AK. Reviewer Report For: Case Report: Solitary fibrous tumor of the eyelid in a child: a case report and review of the literature [version 1; peer review: 1 approved with reservations] . F1000Research 2025, 14 :304 ( https://doi.org/10.5256/f1000research.175358.r376154 ) The direct URL for this report is: https://f1000research.com/articles/14-304/v1#referee-response-376154 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 26 May 2025 Ahmet Kaan Gündüz , Ankara University, Ankara, Turkey Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.175358.r376154 The authors report a case of solitary fibrous tumor of the eyelid in a child and a literature review. Please provide details of the literature review in the Methods section. Please provide the results ... Continue reading READ ALL The authors report a case of solitary fibrous tumor of the eyelid in a child and a literature review. Please provide details of the literature review in the Methods section. Please provide the results of the literature review in the Results section. Use SFT throughout the text. Discussion: "Malignancy is defined by having more than four mitoses per high-power field or having abnormal mitotic figures, as well as having cellular pleomorphism or tumor giant cells." Did the authors want to give general information here? If it is about the SFT case, please provide a reference. Please provide a reference for a case with tuberous sclerosis in the Discussion section. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? No Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Ocular Oncology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Gündüz AK. Reviewer Report For: Case Report: Solitary fibrous tumor of the eyelid in a child: a case report and review of the literature [version 1; peer review: 1 approved with reservations] . F1000Research 2025, 14 :304 ( https://doi.org/10.5256/f1000research.175358.r376154 ) The direct URL for this report is: https://f1000research.com/articles/14-304/v1#referee-response-376154 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 17 Mar 2025 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. 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This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The authors report a case of solitary fibrous tumor of the eyelid in a child and a literature review. Please provide details of the literature review in the Methods section. Please provide the results of the literature review in the Results section. Use SFT throughout the text. Discussion: "Malignancy is defined by having more than four mitoses per high-power field or having abnormal mitotic figures, as well as having cellular pleomorphism or tumor giant cells." Did the authors want to give general information here? If it is about the SFT case, please provide a reference. Please provide a reference for a case with tuberous sclerosis in the Discussion section. Is the background of the case’s history and progression described in sufficient detail? Yes Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Yes Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment? No Is the case presented with sufficient detail to be useful for other practitioners? Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Ocular Oncology I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (0) Gündüz AK. Peer Review Report For: Case Report: Solitary fibrous tumor of the eyelid in a child: a case report and review of the literature [version 1; peer review: 1 approved with reservations] . F1000Research 2025, 14 :304 ( https://doi.org/10.5256/f1000research.175358.r376154) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. 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