Data and Code for Integrative Transcriptomic Analysis of Chronic Pelvic Pain and Endometriosis Identifies a Reproducible Histone-Cluster-Driven Autoimmune Program in Eutopic Endometrium

Xinyue Cui
2026 · doi:10.5281/zenodo.20111150 · W7160772482
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Integrative transcriptomic re-analysis of chronic pelvic pain and endometriosis data identified a reproducible histone-cluster-driven autoimmune program in eutopic endometrium.

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This dataset provides the underlying data and code for an integrative transcriptomic re-analysis of chronic pelvic pain and endometriosis, utilizing public gene expression profiles from datasets GSE281916 and GSE153739. The study identified a reproducible histone-cluster-driven autoimmune program within eutopic endometrial tissue, which was validated through independent replication in the GSE51981 cohort. This finding highlights specific epigenetic and immune mechanisms associated with the condition. This paper is centrally about endometriosis — specifically focusing on transcriptomic signatures in eutopic endometrium linked to chronic pelvic pain.

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Abstract

Integrative transcriptomic re-analysis of CPP and endometriosis (GSE281916, GSE153739) with independent replication in GSE51981
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Published May 10, 2026 | Version v1 Dataset Open Data and Code for Integrative Transcriptomic Analysis of Chronic Pelvic Pain and Endometriosis Identifies a Reproducible Histone-Cluster-Driven Autoimmune Program in Eutopic Endometrium Authors/Creators Description Integrative transcriptomic re-analysis of CPP and endometriosis (GSE281916, GSE153739) with independent replication in GSE51981 Files diff_ControlvsLINC01638_all.csv Files (16.3 MB) | Name | Size | Download all | |---|---|---| | md5:e7ec71330c4c116894f08f264b3a38cb | 9.2 kB | Download | | md5:b9013365930e3a4b3a412351f3a5d12a | 4.1 kB | Download | | md5:8ec22d142d9477b56382e4d1ed44c90b | 4.5 MB | Preview Download | | md5:3d1eddc328bb58443d286f9aa591e23b | 245.6 kB | Preview Download | | md5:bd1e98ab2e9c3cf2a4a351956975272f | 1.2 MB | Preview Download | | md5:a9fac5a4fd47de4edf7bbceb47d13f4a | 1.2 MB | Preview Download | | md5:711ff979b6b3720dd6bd0fc3a354d881 | 542.4 kB | Preview Download | | md5:bd1e98ab2e9c3cf2a4a351956975272f | 1.2 MB | Preview Download | | md5:711ff979b6b3720dd6bd0fc3a354d881 | 542.4 kB | Preview Download | | md5:a9fac5a4fd47de4edf7bbceb47d13f4a | 1.2 MB | Preview Download | | md5:a5b7af760e1f4c73e1dd01f0430f6e1f | 71.7 kB | Preview Download | | md5:491d339cd229086b4fa50df47c67b706 | 67.8 kB | Preview Download | | md5:571b50de32da1845de5aad5035c2610b | 38.4 kB | Preview Download | | md5:a5b7af760e1f4c73e1dd01f0430f6e1f | 71.7 kB | Preview Download | | md5:571b50de32da1845de5aad5035c2610b | 38.4 kB | Preview Download | | md5:491d339cd229086b4fa50df47c67b706 | 67.8 kB | Preview Download | | md5:3e8d1f27b3b1290456ade85236e2881a | 4.5 MB | Preview Download | | md5:6dfd830290b9cffabe780daa5c0331be | 240.1 kB | Preview Download | | md5:5c7b83ca68147f545d9e5b54c3eec60c | 246.0 kB | Preview Download | | md5:b202a9e11220a01cbd26c319f181baf7 | 429 Bytes | Preview Download | | md5:e88b326fd4a41a66f35f0bbdf1e3007e | 144.9 kB | Preview Download | | md5:4e4ba4e5129b53acc387fa42d9cc1f7b | 141.7 kB | Preview Download |

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endometriosischronic_pelvic_pain

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last seen: 2026-08-09T06:04:05.141522+00:00
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