Dataset for: Characteristics of transferrin saturation and anemia-related biomarkers in patients with uterine adenomyosis

Mari Kawamata, Fumitake Ito, Nanami Tahara, Akiyo Kakibuchi, Kazuya Yabumoto, Yuko Izumi, Akihisa Katayama, Taisuke Mori
2026 · doi:10.5281/zenodo.18637560 · W7138264573
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study analyzed iron metabolism markers in women with uterine adenomyosis, finding iron deficiency more common than anemia and demonstrating that transferrin saturation combined with ferritin improves iron deficiency detection.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

This retrospective dataset paper compiles anonymized clinical data from non-menopausal women aged 30–55 years who had iron metabolism biomarkers measured at first visit, assessing anemia and iron deficiency patterns in uterine adenomyosis. Using Hb <11 g/dL for anemia and three iron deficiency definitions (ferritin-only <20 ng/mL, TSAT-only <20%, or combined ferritin <20 ng/mL and/or TSAT <20%), the study found iron deficiency was more prevalent than anemia across all groups, and in the adenomyosis group the combined criterion identified significantly more iron deficiency than ferritin alone. The authors also examined correlations between Hb and TSAT (Hb vs log[TSAT]), reporting a weak relationship in the adenomyosis group compared with stronger correlations in myoma and no structural abnormality groups. The paper explicitly notes a key limitation that ferritin can be confounded by inflammation, motivating TSAT use for detection of functional iron deficiency. This paper is centrally about endometriosis and/or adenomyosis—specifically uterine adenomyosis—by evaluating TSAT and ferritin for diagnosing iron deficiency and functional iron deficiency in women with adenomyosis.

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Abstract

This dataset contains the anonymized clinical data analyzed in the study titled "Characteristics of transferrin saturation and anemia-related biomarkers in patients with uterine adenomyosis". Abstract:Background: Ferritin may be elevated as an acute-phase reactant in inflammatory conditions, potentially masking iron deficiency. We aimed to evaluate the frequency of iron deficiency and the diagnostic significance of transferrin saturation (TSAT) in women with uterine adenomyosis. Methods: This retrospective study included non-menopausal women aged 30–55 years who had iron metabolism markers measured at first visit. Anemia was defined as hemoglobin (Hb) <11 g/dL. Iron deficiency was defined using three criteria: ferritin-only (serum ferritin <20 ng/mL), TSAT-only (TSAT <20%), and a combined criterion (ferritin <20 ng/mL and/or TSAT <20%). Functional iron deficiency was defined as TSAT <20%, with ferritin ≥20 ng/mL. We compared the frequencies of anemia and iron deficiency across groups and evaluated correlations between Hb and TSAT. Results: Iron deficiency was more common than anemia in all patient groups. In the adenomyosis group, the frequency of iron deficiency based on the combined criterion was significantly higher than that diagnosed using ferritin alone. The correlation between Hb and log(TSAT) was weak in the adenomyosis group but strong in the myoma and no uterine structural abnormality groups. Conclusions: Measuring TSAT and ferritin levels enhances the detection of iron deficiency in women with adenomyosis and may help identify functional iron deficiency when ferritin interpretability is limited by inflammation.
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Abstract

Background: Ferritin may be elevated as an acute-phase reactant in inflammatory conditions, potentially masking iron deficiency. We aimed to evaluate the frequency of iron deficiency and the diagnostic significance of transferrin saturation (TSAT) in women with uterine adenomyosis.

Methods

This retrospective study included non-menopausal women aged 30–55 years who had iron metabolism markers measured at first visit. Anemia was defined as hemoglobin (Hb) <11 g/dL. Iron deficiency was defined using three criteria: ferritin-only (serum ferritin <20 ng/mL), TSAT-only (TSAT <20%), and a combined criterion (ferritin <20 ng/mL and/or TSAT <20%). Functional iron deficiency was defined as TSAT <20%, with ferritin ≥20 ng/mL. We compared the frequencies of anemia and iron deficiency across groups and evaluated correlations between Hb and TSAT.

Results

Iron deficiency was more common than anemia in all patient groups. In the adenomyosis group, the frequency of iron deficiency based on the combined criterion was significantly higher than that diagnosed using ferritin alone. The correlation between Hb and log(TSAT) was weak in the adenomyosis group but strong in the myoma and no uterine structural abnormality groups.

Conclusions

Measuring TSAT and ferritin levels enhances the detection of iron deficiency in women with adenomyosis and may help identify functional iron deficiency when ferritin interpretability is limited by inflammation. Files Adenomyosis_Iron_Deficiency_Dataset.csv Files (11.5 kB) | Name | Size | Download all | |---|---|---| | md5:99531ed0b211e7ff5f34c1923cf5364c | 11.5 kB | Preview Download |

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last seen: 2026-06-04T00:00:01.174412+00:00
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