New Advances in Endometriosis Surgery Combined with Drug Therapy

荣 刘
In: Advances in Clinical Medicine · 2020 · vol. 10(07) , pp. 1511–1515 · doi:10.12677/acm.2020.107227 · W4249844106
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This review discusses advances in surgical treatment for endometriosis combined with traditional drug therapies and future directions for novel drug development.

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This review article examines the evolving landscape of surgical and pharmacological interventions for endometriosis, a condition characterized by invasive lesions that cause pelvic pain and infertility. The authors discuss recent advancements in combining traditional drug therapies, such as GnRH agonists, mifepristone, and glucocorticoids, with laparoscopic surgery to improve outcomes and reduce recurrence rates. Specific attention is given to novel approaches like reverse additive therapy and the use of anti-inflammatory agents during or after surgical excision to mitigate inflammatory responses. This paper is centrally about endometriosis — specifically reviewing new advances in combined surgical and medical management strategies.

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子宫内膜异位症手术联合药物治疗的新进展 New Advances in Endometriosis Surgery Combined with Drug Therapy New Advances in Endometriosis Surgery Combined with Drug Therapy DOI: 10.12677/ACM.2020.107227, PDF, 被引量 作者: 刘 荣, 高成英：延安大学附属医院，陕西 延安 关键词: 子宫内膜异位症；反向添加疗法；糖皮质激素；米非司酮；药物治疗；Endometriosis； Reverse Additive Therapy； Glucocorticoid； Mifepristone； Drug Treatment 作者: 刘 荣, 高成英：延安大学附属医院，陕西 延安 关键词: 子宫内膜异位症；反向添加疗法；糖皮质激素；米非司酮；药物治疗；Endometriosis； Reverse Additive Therapy； Glucocorticoid； Mifepristone； Drug Treatment 摘要: 子宫内膜异位症(Endometriosis)是育龄期妇女的常见病。EMs引起盆腔痛和不孕，严重影响女性的健康和生活质量，甚至被称为“良性癌”，其病变广泛，形态多样，极具侵袭和复发性，是难治之症。本文主要阐述EMs手术治疗联合传统药物治疗的新进展以及未来新型药物发展的方向。 Abstract: Endometriosis (EMs) is a common disease in women of childbearing age. EMs causes pelvic pain and infertility, seriously affecting women’s health and quality of life, even known as “benign cancer”. Its lesions are extensive, diverse, extremely invasive and recurrent. It is a refractory disease. This paper mainly describes the new progress of EMs surgery combined with traditional drug therapy and the development direction of new drugs in the future. 文章引用：刘荣, 高成英. 子宫内膜异位症手术联合药物治疗的新进展[J]. 临床医学进展, 2020, 10(7): 1511-1515. https://doi.org/10.12677/ACM.2020.107227 | [1] | 许占英. 腹腔镜手术分别联合孕三烯酮胶囊与GnRH-a治疗子宫内膜异位症的比较[J]. 中国药物与临床, 2016, 16(5): 702-703. | | [2] | Campo, S., Campo, V. and Gambadauro, P. (2014) Is a Positive Family History of Endometriosis a Risk Factor for Endometrioma Recurrence after Laparoscopic Surgery. Reproductive Sciences, 21, 526-531. [Google Scholar] [CrossRef] [PubMed] | | [3] | 王敏, 潘月. 腹腔镜下微创治疗对子宫内膜异位症患者复发率及妊娠率的影响[J]. 实用妇科内分泌杂志(电子版), 2017, 4(19): 9-10 | | [4] | 孙瑞琼, 梁超鹏, 张同美, 等. 卵巢子宫内膜异位症复发的相关因素分析[J], 生殖医学杂志, 2016, 25(5): 439-443. | | [5] | 卞美璐, 黄书慧, 邓文红, 等. 醋酸亮丙瑞林微球治疗子宫内膜异位症随机盲法II期临床试验[J]. 中华妇产科杂志, 2015, 50(3): 188-193. | | [6] | 任婉婷, 张秀玲. 反向添加疗法联合醋酸亮丙瑞林在子宫内膜异位症病灶切除术后的应用效果及对机体Th1/Th2漂移现象的影响[J]. 临床医学研究与实践, 2020, 15: 68-70. | | [7] | 魏江平, 陈欢, 任香怡, 等. 益胃汤对子宫内膜异位症模型大鼠Th1/Th2漂移的影响[J]. 成都中医药大学学报, 2016, 39(3): 16-19. | | [8] | 孟宪宁, 李红霞, 霍志平, 等. 长效糖皮质激素联合促性腺激素释放激动剂腹腔镜术腔冲洗在子宫内膜异位症治疗中的应用效果[J]. 中国医药导报, 2018, 15(29): 74-78. | | [9] | 沈玉英. 地塞米松联合曲普瑞林腹腔镜术腔冲洗在治疗子宫内膜异位症中的应用效果[J]. 中国妇幼保健, 2017, 32(19): 4667-4669 | | [10] | 冯子豪, 蒋苹, 韩雪松, 等. 腹腔镜手术联合地塞米松术腔冲洗治疗子宫内膜异位症的疗效观察[J]. 昆明医科大学学报, 2016, 37(3): 96-99. | | [11] | 赵亚. 地塞米松联合曲普瑞林及腹腔镜手术治疗子宫内膜异位症疗效观察[J]. 中国合理用药探索, 2019, 16(8): 1977-1979. | | [12] | Monsivais, D., Dyson, M.T., Yin, P., et al. (2014) ERβ- and Prostaglandin E2-Regulated Pathways Integrate Cell Proliferation via RAS-Like and Estrogen-Regulated Growth Inhibitor in Endometriosis. Molecular Endocrinology, 28, 1304-1315. [Google Scholar] [CrossRef] [PubMed] | | [13] | Joshi, N.R., Su, R.W., Chandramouli, G.V., et al. (2015) Altered Expression of Micro RNA-451 in Eutopic Endometrium of Baboons (Papio anubis) with Endometriosis. Human Reproduction, 30, 2881-2891. [Google Scholar] [CrossRef] [PubMed] | | [14] | 梁栋, 张四友, 钟沛文, 朱敏珊, 李维茹. 糖皮质激素联合GnRH-α在轻度子宫内膜异位症合并复发性早期流产患者中的疗效评价[J]. 中国妇产科临床杂志, 2020, 21(2): 145-149. | | [15] | 吴秋艳, 付圣娥, 苏娜. 腹腔镜术后应用不同药物治疗子宫内膜异位症的疗效及安全性探析[J]. 当代医学, 2019, 25(24): 53-55. | | [16] | 尧明凤. 腹腔镜下联合不同药物治疗重度子宫内膜异位症的临床疗效分析[J]. 齐齐哈尔医学院学报, 2014, 24(14): 2046-2048. | | [17] | 刘平, 霍永健, 张丽梅, 汤红梅, 李新立. 用不同剂量的米非司酮联合腹腔镜保守性手术治疗子宫内膜异位症对患者性激素水平的影响[J]. 当代医药论丛, 2019, 17(14): 65-66. | | [18] | 丛珊珊, 张广美. 子宫内膜异位症药物治疗新进展[J]. 中国生育健康志, 2020, 31(3): 292-295. | | [19] | Cheng, G., Coolen, L.M., Padmanabhan, V., et al. (2010) The Kisspeptin/Neurokinin b/Dynorphin (KNDy) Cell Population of the Arcuate Nucleus: Sex Differences and Effects of Prenatal Testosterone in Sheep. Endocrinology, 151, 301. [Google Scholar] [CrossRef] [PubMed] | | [20] | Navarro, V.M., Gottsch, M.L., Chavkin, C., et al. (2009) Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin Bneurons in the Arcuate Nucleus of the Mouse. Journal of Neuroscience, 29, 11859-11866. [Google Scholar] [CrossRef] | | [21] | Brawn, J., Morotti, M., Zondervan, K.T., et al. (2014) Central Changes Associated with Chronic Pelvic Pain and Endometriosis. Human Reproduction, 20, 737-747. [Google Scholar] [CrossRef] [PubMed] | | [22] | As-Sanie, S., Harris, R.E., Napadow, V., et al. (2012) Changes in Regional Gray Matter Volume in Women with Chronic Pelvic Pain: A Voxel-Based Morphometry Study. Pain, 153, 1006-1014. [Google Scholar] [CrossRef] [PubMed] | | [23] | Williams, C., Hoang, L., Yosef, A., et al. (2015) Nerve Bundles and Deep Dyspareunia in Endometriosis. Reproductive Sciences, 23, 892-901. [Google Scholar] [CrossRef] [PubMed] | | [24] | Rahmioglu, N., Nyholt, D.R., Morris, A.P., et al. (2014) Genetic Variants Underlying Risk of Endometriosis: Insights from Meta-Analysis of Eight Genome-Wide Association and Replication Datasets. Human Reproduction Update, 20, 702-716. [Google Scholar] [CrossRef] [PubMed] |

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