Low Dose Marantodes pumilum Leaf and Roots Extracts Preserved Bone Structure in Ovariectomized Rats

Tijjani Rabiu Giaz, Ahmad Nazrun Shu, Ima Nirwana So, Norliza Muhammad, Norazlina Mohamed
In: International Journal of Osteoporosis and Metabolic Disorders · 2016 · vol. 10(1) , pp. 1–9 · doi:10.3923/ijom.2017.1.9 · W2747652145
article OA: diamond CC0
🔓 Open OA copy View on OpenAlex View at publisher

Abstract

Background: Marantodes pumilum var. alata, a phytoestrogen-rich herb, has been reported to exert protection on bone of estrogen-deficient animals against osteoporosis. However, comparative osteo-protective activity of its leaf and root extracts has not been fully elucidated. Objective: The aim of this study was to investigate and compare the osteo-protective effects of aqueous leaf and root extracts of Marantodes pumilum var alata in ovariectomized rat model. Methodology: Twenty-seven female rats were divided into nine groups: sham-operated (Sham); ovariectomized control (OVXC); 64.5 g kgG 1 dayG 1 estrogen treatment (ERT); 20 mg kgG 1 dayG 1 (MPv20), 50 mg kgG 1 dayG 1 (MPv50) and 100 mg kgG 1 dayG 1 (MPv100) doses leaf extract treatments and; 20 mg kgG 1 dayG 1 (MPr20), 50 mg kgG 1 dayG 1 (MPr50) and 100 mg kgG 1 dayG 1 (MPr100) doses root extract treatment groups. After 8 weeks treatment period, the left femora were excised and investigated using Micro-computed tomography (-CT). Results were analysed using one-way ANOVA and Tukey's post hoc test. Results: The MPv20, MPv50 and MPr20 groups showed significantly higher (p<0.05) bone mineral density on the trabecular bone while all treatment groups recorded significantly higher (p<0.05) tissue mineral density on the cortical bone when compared with OVXC group. Trabecular bone number and separation were significantly higher and lower (p<0.05), respectively, in both MPv20 and MPr20 groups. Significantly higher (p<0.05) cortical bone area fraction and thickness in MPv20 group and medullary area in MPr20 group were observed. Conclusion: Lower dose (20 mg kgG 1 dayG 1 ) of both leaf and root extracts of Marantodes pumilum var alata preserved bone mineral density and micro-architecture of estrogen-deficient rats better than higher doses.

My notes (saved in your browser only)

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (25)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK