The postoperative application of Gonadotropin-releasing hormone agonist (GnRHa) combined with Climen in the conservative treatment of endometriosis

Objective To explored the clinical efficacy and security of Gonadotropin- releasing hormone agonist(GnRHa) combined with Climen in the conservative treatment of endometriosis. Methods A total of 82 patients with EMS were analyzed from January 2012 to January 2013, the patients were divided into the treatment group(42 patients)and control group(40 patients)by random number table method after operation. The two groups were both given 3.6 mg GnRHa each time in every 28 days and the treatment lasted 6 times. In addition, the patients in the treatment group were continuously given Climen and pentanoic acid estradiol 2 mg a day for 11 days and 2 mg of estradiol cyproterone a day and the treatment lasted for 10 days.A number of index were compared in terms of clinical curative effect, hormonal level[estradiol(E2)], folliclestimulating hormone(FSH), luteinizing hormone(LH), the score of Visual Analogue Scale(VAS),bone mineral density,bone density,Bone Gla Protein(BGP), recurrence,pregnancy rate in one year and safety.Results The entire response rate was respectively 55.0% and 83.3%, the partial response rate was 37.5% and 14.3%, the recurrence rate was 7.5% and 2.4% in control group and the treatment group(P 0.05). The postoperative levels of E2, FSH, LH were significantly lower than the previous treatment in two groups(P 0.05). The differences were statistically significant according to comparison of the scores of Kupperman, BGP as well as pregnancy rate in one year in the two groups. The results of feebleness, sexual hypoactivity, dizziness and night sweating revealed that the differences were statistically significant(P 0.05). Conclusion The therapy of GnRHa combined with Climen could improve clinical curative effect, reduce the hormone levels, enhance the quality of life in patients and decrease adverse reactions.