Transplantation of Autologous Fat, Stromal Vascular Fraction (SVF) Cell and Platelet Rich Plasma (PRP) for Cell Therapy of Atrophic Acne Scars: Clinical Evaluation and Biometric Assessment

Abstract Background: Scarring is an unfortunate result of acne, because it causes psychological and cosmetic problems to patients. Unluckily no single treatment is suitable; using multiple methods may have better result. autologous fat and stromal vascular fraction (SVF) cells and their secretory factors can and enhance angiogenesis, collagen synthesis, and migration of fibroblasts therefore regenerate hurt tissues. Also, other treatments for acne scarring, like platelet rich plasma (PRP), induce the scare improvement. The aim of the study was to verify the effectiveness of transplantation of autologous fat, SVF cells and PRP as cell therapy technique on atrophic acne scars. Methods: This study included 9 adult patients with atrophic acne scars on the face. All patients received transplantation of autologous fat, stromal vascular fraction (SVF) cells and PRP. The treatment outcome was measured by biometric assessment (Visioface 1000 D, Colorimeter, multi probe adapter Cutometer, Tewameter, Mexameter, and skin ultrasound imaging system), also patients’ satisfaction was evaluated. The patients were followed 6 months after treatment. Results: A significant improvement in the skin pores, spots, skin lightness and melanin content of the skin, skin elasticity and TEWL after 6 months of treatment. Also denser skin layers were observed both in the epidermis and dermis. Furthermore, 66.6 % of the patients showed well satisfied after treatment. Conclusion: Briefly, transplantation of autologous fat, SVF cells and PRP is an effective cell therapy for atrophic acne scars.