Activity of nucleolar organizers in endometrial glandular and surface epithelial cells in patients with external genital endometriosis

Evgeny L. Kurenkov, Elena V. Igenbaeva, Т. В. Узлова
In: Journal of obstetrics and women's diseases · 2018 · vol. 67(6) , pp. 45–49 · doi:10.17816/jowd67645-49 · W2912204686
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Endometriosis patients exhibit significantly increased ribosomal activity in endometrial epithelial cells during late proliferation and early/mid-secretion phases, but decreased activity in late secretion compared to controls.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

Kurenkov, Igenbaeva, and Uzlova assessed nucleolar organizer activity in endometrial glandular and surface epithelial cells in 68 reproductive-age women, comparing those with laparoscopically confirmed external genital endometriosis (stages I–III, n=38) versus controls without it (n=30) across menstrual-cycle stages using Crocker’s silver staining method. They found significantly increased ribosomal/nucleolar activity—reflected by higher counts of nucleoli and argentaffin inclusions—in both epithelial cell types in the late proliferation and early/mid-secretory phases, alongside a significant decrease in nucleolar organizer activity specifically in the late secretory stage. The authors attribute these cyclic differences to altered ribosomal synthesis possibly linked to greater proliferative, adhesive, and invasive potential, which they suggest could support formation of endometrioid heterotopias; a key caveat is that the study is observational and interprets mechanism from histologic markers rather than testing causality. This paper is centrally about endometriosis — it measures nucleolar organizer activity in eutopic endometrial epithelial cells across the menstrual cycle in patients with external genital endometriosis.

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Abstract

Hypothesis/aims of study. Endometriosis is a disease characterized by proliferation of tissue that is similar in morphology and function to the endometrium, outside the uterine cavity. Thanks to the theory of J. Sampson (1927), which explains endometrioid heterotopia formation by bits of endometrial tissue migrating through the fallopian tubes during menstruation and their subsequent implantation in the pelvis, research has begun on the biological properties of eutopic endometrial cells in women with endometriosis, which is still relevant today. The present study was aimed to assess the activity of nucleolus organizers in the endometrium in women with external genital endometriosis and without it at different stages of the menstrual cycle. Study design, materials, and methods. Paraffin blocks of endometrial biopsy specimens were taken from 68 women with and without external genital endometriosis. The activity of nucleolar organizers was evaluated by the method of J. Crocker (1983). Results. The data obtained showed a significant increase in ribosomal activity in the cells of the endometrial glandular and surface epithelium in women with external genital endometriosis at the stages of late proliferation, as well as early and middle secretions. There was also a significant decrease in the activity of the nucleolar organizers of endometrial epithelial cells at the stage of late secretion in women with external genital endometriosis. Conclusion. The obtained differences in regulation of ribosomal synthesis in the cells of the integument and glandular epithelium of the endometrium in women with external genital endometriosis, in our opinion, can provide an increase in the total amount of epitheliocytes of the endometrium, increase their adhesive and invasive abilities, and lengthen the life cycle of cells. This contributes to the formation of endometrioid heterotopies and the development of external genital endometriosis. Changes in the activity of nucleolar organizers in the endometrium in women with external genital endometriosis may be of clinical interest for the diagnosis of this pathology.

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endometriosis

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