Basal ganglia subregion volume changes between acute-phase schizophrenia and bipolar disorder

Basal ganglia subregion volume changes between acute-phase schizophrenia and bipolar disorder | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Basal ganglia subregion volume changes between acute-phase schizophrenia and bipolar disorder Yilin Tang, Ruiqiu Zhu, Yucheng Ling, Yifan Wang, Yingbo Dong, and 6 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7607942/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background and Hypothesis: Schizophrenia (SCZ) and bipolar disorder (BD) have a certain degree of overlap in terms of diagnosis, pathophysiology, and genetic levels, which may be related to the existence of similar biological backgrounds in both, especially when psychosis symptoms are present. Study Design: This study included 90 patients with SCZ, 60 patients with psychotic bipolar disorder (P-BD), 22 patients with non-psychotic bipolar disorder (NP-BD) (all patients were acute-phase patients with a disease duration of less than 5 years), and 100 healthy control (HC) group, who all underwent structural magnetic resonance imaging (MRI) scans. Covariance analysis was performed using SPSS 26.0 to compare the differences in basal ganglia volume between the groups. Study Results: The results showed significant differences in the volumes of the left putamen (F=6.511, P=0.002), right putamen (F=5.416, P=0.005), left pallidum (F=29.920, P<0.001), and right pallidum (F=12.513, P<0.001) in the SCZ group, P-BD group and HC group. Meanwhile, there were significant differences in the volumes of the left pallidum (F=6.776, P=0.001) and right putamen (F=9.930, P<0.001) in the P-BD group, NP-BD group and HC group. Conclusions: We found a significant difference between P-BD and SCZ, but no such difference was observed between P-BD and NP-BD, although the observed difference between groups may be partly attributable to exposure to antipsychotic medications. Schizophrenia Bipolar disorder Psychosis symptoms MRI Basal ganglia Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7607942","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":528389952,"identity":"77fc1081-cb34-4dbe-8e12-379a1428c4ab","order_by":0,"name":"Yilin Tang","email":"","orcid":"","institution":"Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical Universit","correspondingAuthor":false,"prefix":"","firstName":"Yilin","middleName":"","lastName":"Tang","suffix":""},{"id":528389953,"identity":"46e0d530-ec56-4072-b506-a04d2a641fd2","order_by":1,"name":"Ruiqiu Zhu","email":"","orcid":"","institution":"Department of 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ganglia","lastPublishedDoi":"10.21203/rs.3.rs-7607942/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7607942/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground and Hypothesis: \u003c/strong\u003eSchizophrenia (SCZ) and bipolar disorder (BD) have a certain degree of overlap in terms of diagnosis, pathophysiology, and genetic levels, which may be related to the existence of similar biological backgrounds in both, especially when psychosis symptoms are present.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStudy Design: \u003c/strong\u003eThis study included 90 patients with SCZ, 60 patients with psychotic bipolar disorder (P-BD), 22 patients with non-psychotic bipolar disorder (NP-BD) (all patients were acute-phase patients with a disease duration of less than 5 years), and 100 healthy control (HC) group, who all underwent structural magnetic resonance imaging (MRI) scans. Covariance analysis was performed using SPSS 26.0 to compare the differences in basal ganglia volume between the groups.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStudy Results: \u003c/strong\u003eThe results showed significant differences in the volumes of the left putamen (F=6.511, P=0.002), right putamen (F=5.416, P=0.005), left pallidum (F=29.920, P\u0026lt;0.001), and right pallidum (F=12.513, P\u0026lt;0.001) in the SCZ group, P-BD group and HC group. Meanwhile, there were significant differences in the volumes of the left pallidum (F=6.776, P=0.001) and right putamen (F=9.930, P\u0026lt;0.001) in the P-BD group, NP-BD group and HC group.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions:\u003c/strong\u003eWe found a significant difference between P-BD and SCZ, but no such difference was observed between P-BD and NP-BD, although the observed difference between groups may be partly attributable to exposure to antipsychotic medications.\u003c/p\u003e","manuscriptTitle":"Basal ganglia subregion volume changes between acute-phase schizophrenia and bipolar disorder","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-10-16 19:01:25","doi":"10.21203/rs.3.rs-7607942/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"c0a003bc-77c3-43bd-b5ac-d5633d0a7f07","owner":[],"postedDate":"October 16th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-11-10T11:38:20+00:00","versionOfRecord":[],"versionCreatedAt":"2025-10-16 19:01:25","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7607942","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7607942","identity":"rs-7607942","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}