Expression of fucosyltransferase 4 and Lewis Y in endometriosis and its clinical significance

Objective To explore the expression of LeY and FUT4 in patients with endometriosis and its clinical value.Methods 70 patients with endometriosis confirmed by laparoscopic surgery from March 2010 to June 2012 in Department of Gynecology and Obstetrics,Maternal and Child Health Hospital of Dalian City(our for short),and these patients were divided into eutopic endometrial group and ectopic endometrial group,with 35 patients in each group. 35 patients with uterine fibroids alone in our hospital during the same period were also selected as the control group. Immunohistochemistry and RT-PCR were used to detect the expression of FUT4 and LeY in endometrial tissues of three groups,the significance of their changes were evaluated and analyzed. Results 1Compared with the control group,the positive expression rate of FUT4 in eutopic endometrial group and ectopic endometrium group were significantly improved,and the difference was statistically significant(P 0.05),and the positive expression rate of FUT4 in ectopic endometrial group was higher than that in the eutopic endometrial group,the difference was statistically significant(P 0.05). 2Compared with the control group,positive expression rate of LeY in the eutopic endom etrial group and ectopic endometrium group were significantly improved,and the difference was statistically significant(P 0.05),positive expression rate of LeY in the ectopic endometrial group was higher than that in the eutopic endometrial group,the difference was statistically significant(P 0.05).3Compared with the control group,positive expression rate of FUT4 in the ectopic endometrial group and eu-topic endometrial group was significantly higher,and the difference was statistically significant(P 0.05),while the positive expression rate of FUT4 in the ectopic endometrial group was higher than that in the eutopic endometrial group,the difference was statistically significant(P 0.05). Conclusion FUT4 and LeY not only plays an important role in the formation and development of endometriosis but also in embryonic adhesion and implantation process,especially FUT4 is a key enzyme in the synthesis of LeY,while if a certain threshold is reached with its high expression,it will induce endometriosis,affecting the normal implantation of the embryo,which further leads to infertility.