Measurement of Serum Carbohydrate Antigen-125 in Patients With Endometrial Cysts of the Ovarian and Its Clinical Significance

Wei He
In: Chung-Hua Fu Ch'an K'o Tsa Chih · 2012 · vol. 8(4) , pp. 444–446 · doi:10.3877/cma.j.issn.1673-5250.2012.04.012 · W3032792349
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This study found that serum CA125 levels were significantly higher in women with endometrial cysts of the ovary than in those with benign ovarian cysts, correlating positively with endometriosis stage and dysmenorrhea severity.

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This study evaluated the clinical significance of serum carbohydrate antigen-125 (CA125) levels in patients with ovarian endometrial cysts compared to those with benign ovarian cysts without endometriosis. The researchers found that CA125 concentrations were significantly higher in the endometriosis group and correlated positively with both the severity of disease staging and the intensity of dysmenorrhea symptoms. These findings indicate that measuring serum CA125 can assist in diagnosing ovarian endometrial cysts and assessing their progression and prognosis. This paper is centrally about endometriosis — specifically, it investigates the diagnostic utility of CA125 as a biomarker for ovarian endometriomas and correlates these levels with disease stage and pain severity.

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Abstract

Objective To study the relationship between serum carbohydrate antigent-125(CA125) and endometrial cysts of ovary(ECO). Methods From 2009 July to 2010 December, a total of 62 cases women with ECO were included in study group, during the same period and in the same hospital, 62 cases with endometriosis (EMs) benign ovarian cysts included in control group, all accepted operation treatment and confirmed by postoperative histopathological examination. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Chengdu Women and Children's Central Hospital. Informed consent was obtained from all participants. There had no significance difference between two groups among ages, body mass index(BMI) and etc.(P>0.05). Levels of serum CA125 in two groups were measured by microparticle enzyme immunoassay, and analysis by statistics methods. Results Levels of serum CA125 in study group were significantly higher than those in control group [(95.36±56.31) U/mL vs. (18.64±7.45) U/mL], There had significance difference(P<0.01). In study group, the relationship between levels of serum CA125 and severity of EMs (EMs stages) had a positive correlation (r=0.8832, P<0.01); serum CA125 levels in patients of EMs Ⅱ-Ⅳ stages were much higher than those in EMs Ⅰ stage, and there had significant difference(P<0.01), and here had significance difference between levels of serum CA125 in EMs Ⅱ stage and Ⅲ stage (P<0.01); levels of serum CA125 and dysmenorrhea severity had a positive correlation (r=0.5650, P<0.01), and there had significance difference between levels of dysmenorrhea severity scores (DSS) 1-3 and 0 (P<0.01). In study group, relationship between levels of serum CA125 and dysmenorrhea severity also had a positively correlated (P<0.01). Conclusions Levels of serum CA125 has bearing on the occurrence, development and prognosis of EOC, Levels of serum CA125 had a positively correlated with EMs stages and DSS. Key words: carbohydrate antigent-125; endometrial cysts of the ovary; serum
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Objective

To study the relationship between serum carbohydrate antigent-125(CA125) and endometrial cysts of ovary(ECO).

Methods

From 2009 July to 2010 December, a total of 62 cases women with ECO were included in study group, during the same period and in the same hospital, 62 cases with endometriosis (EMs) benign ovarian cysts included in control group, all accepted operation treatment and confirmed by postoperative histopathological examination. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Chengdu Women and Children's Central Hospital. Informed consent was obtained from all participants. There had no significance difference between two groups among ages, body mass index(BMI) and etc.(P>0.05). Levels of serum CA125 in two groups were measured by microparticle enzyme immunoassay, and analysis by statistics methods.

Results

Levels of serum CA125 in study group were significantly higher than those in control group [(95.36±56.31) U/mL vs. (18.64±7.45) U/mL], There had significance difference(P<0.01). In study group, the relationship between levels of serum CA125 and severity of EMs (EMs stages) had a positive correlation (r=0.8832, P<0.01); serum CA125 levels in patients of EMs Ⅱ-Ⅳ stages were much higher than those in EMs Ⅰ stage, and there had significant difference(P<0.01), and here had significance difference between levels of serum CA125 in EMs Ⅱ stage and Ⅲ stage (P<0.01); levels of serum CA125 and dysmenorrhea severity had a positive correlation (r=0.5650, P<0.01), and there had significance difference between levels of dysmenorrhea severity scores (DSS) 1-3 and 0 (P<0.01). In study group, relationship between levels of serum CA125 and dysmenorrhea severity also had a positively correlated (P<0.01).

Conclusions

Levels of serum CA125 has bearing on the occurrence, development and prognosis of EOC, Levels of serum CA125 had a positively correlated with EMs stages and DSS. | [1] | Yue J, ed. Obstetrics and gynecology.7th ed[M].Beijing:People's Medical Publishing House, 2008, 329-329. | | [2] | Leng JH, Lang JH, Li HJ, et al.Clinical observation of dysmenorrheal under laparoscope after treating with uterine gland resection and uterine artery obstruction[J]. Chin J Obstet Gynecol, 2006, 41(6):424-425. | | [3] | Fan DM, Chen ZM, Shi HR. Determine of CA125 serum level of endometriosis patients[J]. J Zhengzhou Univ: Med Ed, 2006, 41(2):347-348. | | [4] | Cao CL, Li YL, Zhou J, et al. Clinical assay of three different body fluid of CA125 level in endometriosis patients[J]. China J Mod Med, 2004, 14(21):93-96. | | [5] | Krasnicki D.Serum and peritoneal fluid CA125 concentration in women with endometriosis[J]. Ginekol Pol, 2001, 72(12):1365-1369. | | [6] | Zhu XF, Jiang FY.Determination of CA125 level in serum and cyst fluid of endometriosis patients and its clinical implications[J]. J Xi'an Jiaotong Univ: Med Sci Ed, 2007, 28(6):687-689. | | [7] | Somigliana E, Vigano P, Tirelli AS, et al. Use of the concomitant serum dosage of CA125, CA19-9 and interleukin-6 to detect the presence of endometriosis[J]. Hum Reprod, 2004, 19(8):1871-1876. | | [8] | Cheng YM, Wang ST, Chou C. Serum CA125 in preoperative patients at high risk for endometriosis[J]. Obstet Gynecol, 2002, 99(333):375-380. | | [9] | Shi YF. Endometriosis[M]. Shanghai:Shanghai Science and Technology Press, 2002, 16-24. | | [1] | 钱警语, 郑明明. 《2024意大利妇产科学会非侵入性和侵入性产前诊断指南》解读[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 486-492. | | [2] | 李康虎, 王继伟, 王光远. 腹腔镜下腹股沟疝修补术后并发症及防治进展[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(04): 369-375. | | [3] | 邓杨, 彭豪, 刘剑文. 腹腔镜疝修补术腹膜前负压引流的效果和长期安全性研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(04): 402-405. | | [4] | 申亚伟, 黄新, 李万林. 改良医用胶粘合假疝囊技术预防腹腔镜完全腹膜外疝修补术后血清肿的临床研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(04): 410-413. | | [5] | 张庆峰, 邓旭明, 段巧斌, 姚干, 张策. 腹腔镜完全腹膜外斜疝修补手术关闭内环口对血清肿发生率的影响[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(03): 282-290. | | [6] | 郝智勇, 雷霞, 张国锋, 李锋. 经腹腹膜前疝修补术治疗阴囊疝术后血清肿的相关危险因素分析及预测模型构建[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(03): 291-295. | | [7] | 井发红, 李丽娜, 高婷, 高艳梅, 杨楠, 李卓, 慕玉东. 肺癌立体定向放疗血清SAP 和MMPs 表达及临床意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 707-713. | | [8] | 张春玉, 陈海云, 肖忠萍, 罗琴, 潘运昌. 血清NT-proBNP 预测肺栓塞心脏功能障碍的临床分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 805-808. | | [9] | 周璇, 谢莉, 邹娟. 尼达尼布对特发性肺纤维化肺功能、肺纤维化程度及PDGF、PGE2、TGF-β1的影响[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(03): 368-372. | | [10] | 吴洁柔, 王琴, 张静, 周耿标, 赖芳, 韩云. 体质量指数、血清白蛋白联合mNUTRIC评分对重症肺炎预后的意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(03): 392-396. | | [11] | 刘思含, 张静. 老年人血清铁与C 反应蛋白的比值及25-羟基维生素D3 与肾功能受损的关系研究[J/OL]. 中华肾病研究电子杂志, 2024, 13(05): 268-272. | | [12] | 杨菲, 刘腾飞, 赵志军, 李睿聪, 张颉, 刘妍, 赵珍. 血清维生素水平与分化型甲状腺癌的关联性研究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 633-640. | | [13] | 王子阳, 王宏宾, 刘晓旌. 血清标志物对甲胎蛋白阴性肝细胞癌诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 677-681. | | [14] | 田峰瑞, 蒋锦源, 李阳, 张连阳. Morel-Lavallée 损伤继发血清肿一例[J/OL]. 中华诊断学电子杂志, 2024, 12(04): 245-248. | | [15] | 赵方, 邓宇傲, 饶嫚, 刘瑜, 邓秋霞, 张秋月, 张海涛, 宋莹, 王思苑, 贾新云, 刘映霞. HIV/TB 双重感染者发生免疫重建炎性综合征时血清锌及相关炎症因子的变化特征[J/OL]. 中华卫生应急电子杂志, 2024, 10(04): 213-217. | | 阅读次数 | ||||| | 全文 | | |||| | 摘要 | | |||| 版权所有 中华医学会 中华医学电子音像出版社有限责任公司 京ICP备14006079号-1 网络出版服务许可证：(署)网出证(京)字第075号 AI 小 编 AI小编

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