Measurement of Serum Carbohydrate Antigen-125 in Patients With Endometrial Cysts of the Ovarian and Its Clinical Significance

Objective To study the relationship between serum carbohydrate antigent-125(CA125) and endometrial cysts of ovary(ECO). Methods From 2009 July to 2010 December, a total of 62 cases women with ECO were included in study group, during the same period and in the same hospital, 62 cases with endometriosis (EMs) benign ovarian cysts included in control group, all accepted operation treatment and confirmed by postoperative histopathological examination. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Chengdu Women and Children's Central Hospital. Informed consent was obtained from all participants. There had no significance difference between two groups among ages, body mass index(BMI) and etc.(P>0.05). Levels of serum CA125 in two groups were measured by microparticle enzyme immunoassay, and analysis by statistics methods. Results Levels of serum CA125 in study group were significantly higher than those in control group [(95.36±56.31) U/mL vs. (18.64±7.45) U/mL], There had significance difference(P<0.01). In study group, the relationship between levels of serum CA125 and severity of EMs (EMs stages) had a positive correlation (r=0.8832, P<0.01); serum CA125 levels in patients of EMs Ⅱ-Ⅳ stages were much higher than those in EMs Ⅰ stage, and there had significant difference(P<0.01), and here had significance difference between levels of serum CA125 in EMs Ⅱ stage and Ⅲ stage (P<0.01); levels of serum CA125 and dysmenorrhea severity had a positive correlation (r=0.5650, P<0.01), and there had significance difference between levels of dysmenorrhea severity scores (DSS) 1-3 and 0 (P<0.01). In study group, relationship between levels of serum CA125 and dysmenorrhea severity also had a positively correlated (P<0.01). Conclusions Levels of serum CA125 has bearing on the occurrence, development and prognosis of EOC, Levels of serum CA125 had a positively correlated with EMs stages and DSS. Key words: carbohydrate antigent-125; endometrial cysts of the ovary; serum