QUALITY OF LIFE IN PHYSICAL AND SEXUAL DIMENSIONS AMONG WOMEN UNDERGOING HYSTERECTOMY AND HORMONE-THERAPY BECAUSE OF ABNORMAL UTERINE BLEEDING
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Novel 3-aminopyrrolidine derivatives were synthesized, with piperidine and piperazine compounds identified as highly potent antagonists of the human chemokine receptor 2.
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Abstract
Novel 3-aminopyrrolidine derivatives were synthesized and evaluated for their antagonistic activity against human chemokine receptor 2. Structure-activity studies on 3-aminopyrrolidine incorporating heteroatomic carbocycle moieties led to piperidine compound 19, and piperazine compounds 42, 47 and 49 as highly potent hCCR2 antagonists.
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