Isolated Abdominal Wall Endometriosis Presenting as an Anterior Abdominal Mass: Histopathological Confirmation

Isolated Abdominal Wall Endometriosis Presenting as an Anterior Abdominal Mass: Histopathological Confirmation | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL Clinical Case Reports This is a preprint and has not been peer reviewed. Data may be preliminary. 4 September 2025 V1 Latest version Share on Isolated Abdominal Wall Endometriosis Presenting as an Anterior Abdominal Mass: Histopathological Confirmation Authors : MUHAMMAD UMAR AHSAN 0009-0008-0627-2521 , Saba Shaheen , Muhammad Mudasir , Nadia Qadir , and Somaiya Ahmed 0009-0004-4300-5941 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175700472.26138954/v1 Published Clinical Case Reports Version of record Peer review timeline 238 views 191 downloads Contents Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Title Isolated Abdominal Wall Endometriosis Presenting as an Anterior Abdominal Mass: Histopathological Confirmation Authors: 1-Muhammad Umar Ahsan, MBBS E-mail: [email protected] Affiliation: D.G.Khan medical college, Dera Ghazi Khan, Pakistan ORCID: 0009-0008-0627-2521 2- Dr Saba Shaheen E-mail: [email protected] Affiliation: Post-graduate resident pathology, D.G.Khan medical college, Dera Ghazi Khan, Pakistan 3- Muhammad Mudasir, MBBS E-mail: [email protected] Affiliation: D.G.Khan medical college, Dera Ghazi Khan, Pakistan 4- Dr Nadia Qadir E-mail: [email protected] Affiliation: Post-graduate resident pathology, D.G.Khan medical college, Dera Ghazi Khan, Pakistan 5- Somaiya Ahmed, MBBS E-mail: [email protected] Affiliation: Sir Salimullah Medical College, Dhaka, Bangladesh Corresponding author: Somaiya Ahmed E-mail: [email protected] Affiliation: Sir Salimullah Medical College, Dhaka, Bangladesh Keywords: Abdominal wall endometriosis; Isolated endometriosis; Extra-pelvic endometriosis; Histopathology; Anterior abdominal mass Key Clinical Message Abdominal wall endometriosis should be considered in reproductive-aged women presenting with painful anterior abdominal wall masses, particularly following obstetric or gynecological surgery. Histopathology confirming endometrial glands and stroma within muscle is diagnostic, even when pelvic organs are spared. Clinical Image A 35-year-old woman presented with a gradually enlarging, painful swelling over the anterior abdominal wall, associated with nausea and vomiting. She had a history of hysterectomy 5 years ago. On examination a firm localized mass was palpated in the right anterior abdominal wall, just below the umbilicus. Ultrasound revealed a well-defined hypoechoic lesion beneath the umbilicus, measuring approximately 26 × 14 mm. Surgical excision revealed an abdominal wall mass ( Figure 1A), while the ovaries appeared grossly unremarkable (Figure 1C). Histopathology of the excised mass demonstrated endometrial glands and stroma infiltrating skeletal muscle fibers, confirming endometriosis (Figure 1B). In contrast, ovarian histology showed normal cystic follicles and stroma without endometriotic deposits (Figure 1D). Abdominal wall endometriosis is a rare condition and may clinically mimic abscess, suture granuloma, hematoma, desmoid tumor, sarcoma and metastatic malignancy. While imaging such as ultrasound or MRI is helpful, histopathology remains the gold standard. Importantly, isolated abdominal wall disease without pelvic or ovarian involvement, as in this case, highlights the need for a high index of suspicion in women with a history of prior obstetric or gynecological surgery. Surgical excision with clear margins remains the treatment of choice, offering both definitive diagnosis and symptomatic relief. [1-3]. References: 1-Paramythiotis D, Karlafti E, Tsomidis I, Iraklis G, Malliou P, Karakatsanis A, Antonios M. Abdominal wall endometriosis: a case report. Pan Afr Med J. 2022 Mar 10;41:193. doi: 10.11604/pamj.2022.41.193.33536. PMID: 35685105; PMCID: PMC9146603. 2- Encalada-Soto D, Zaucha D, Mikhail E. Abdominal wall endometriosis: pathogenesis, diagnosis, and update on minimally invasive treatment options: a narrative review. Ann Endosc Laparosc Surg. 2025;10:8. doi: 10.21037/aels-24-72. 3- Gogusev J, Lepelletier Y, Cohen H, Ami O, Validire P. Idiopathic abdominal wall endometrioma: case report with investigation of the pathological, molecular cytogenetic, and cell growth features in vitro. Int J Mol Sci. 2025 Jan 17;26(2):775. doi:10.3390/ijms26020775. Acknowledgments: None to declare Informed Consent: The informed consent was taken in written form from the patient. She gave us consent for her photographs and medical information to be published in print and online with the understanding that this information is publicly available. Authors Contribution; Muhammad Umar Ahsan: Conceptualization, writing, drafting and revision of manuscript; Saba Shaheen: Investigation, Writing original manuscript, Review and editing; Muhammad Mudasir: Writing original manuscript; Nadia Qadir: Review and editing of manuscript Somaiya Ahmed: writing original manuscript Ethics Statement: The paper is exempt from ethical committee approval because of the single case study. Conflict of interest: None to declare Funding: Authors received no funding for this manuscript Supplementary Material File (figures.docx) Download 6.29 MB Information & Authors Information Version history V1 Version 1 04 September 2025 Peer review timeline Published Clinical Case Reports Version of Record 11 Dec 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Collection Clinical Case Reports Keywords obstetrics/gynecology pathology and laboratory medicine Authors Affiliations MUHAMMAD UMAR AHSAN 0009-0008-0627-2521 Ghazi Khan Medical College View all articles by this author Saba Shaheen Ghazi Khan Medical College View all articles by this author Muhammad Mudasir Ghazi Khan Medical College View all articles by this author Nadia Qadir Ghazi Khan Medical College View all articles by this author Somaiya Ahmed 0009-0004-4300-5941 [email protected] Sir Salimullah Medical College View all articles by this author Metrics & Citations Metrics Article Usage 238 views 191 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation MUHAMMAD UMAR AHSAN, Saba Shaheen, Muhammad Mudasir, et al. Isolated Abdominal Wall Endometriosis Presenting as an Anterior Abdominal Mass: Histopathological Confirmation. Authorea . 04 September 2025. DOI: https://doi.org/10.22541/au.175700472.26138954/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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