The Effects of Different Schedules of Far-infrared Rays (FIR) on Uterine Adenomyosis in SHN Mice.

Hiroshi Nagasawa, Keiko Inada
In: Thermal Medicine(Japanese Journal of Hyperthermic Oncology) · 2001 · vol. 17(3) , pp. 133–139 · doi:10.3191/thermalmedicine.17.133 · W2512545251
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

Far-infrared rays and/or whole-body hyperthermia inhibited uterine adenomyosis development when started prenatally or between 2-4 months, but not growth, suggesting different susceptibilities between mammary and uterine lesions.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This study used SHN strain virgin mice, which are highly susceptible to uterine adenomyosis, to examine how different schedules of far-infrared ray (FIR) exposure and whole-body hyperthermia (WBH) affect adenomyosis development and growth. Mice received continued FIR after either 2 or 5 months of age, and/or WBH between 2 and 4 months of age, with various combinations and timing that included FIR exposure from the fetus. The authors found that while mammary tumor development was strongly inhibited under several FIR/WBH schedules, uterine adenomyosis development was suppressed specifically by FIR from the fetus and by WBH alone or in combination with FIR, and neither FIR nor WBH was effective in inhibiting adenomyosis growth once established. This paper is centrally about adenomyosis—effects of different FIR/WBH timing schedules on uterine adenomyosis in SHN mice.

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Abstract

The SHN strain of virgin mice is characterized by a high susceptibility to both mammary tumours and uterine adenomyosis, which are considered to have similar etiological backgrounds. We previously studied the effects of different schedules of irradiation of far-infrared rays (FIR) and/or whole-body hyperthermia (WBH) with FIR on spontaneous mammary tumourigenesis in SHN mice. In the present study, the development and growth of uterine adenomyosis were examined in these mice. Continued exposure to FIR after 2 or 5 months of age and WBH between 2 and 4 months of age alone or in combination with FIR markedly inhibited mammary tumour development ; however, the development of adenomyosis was suppressed by exposure to FIR from the fetus and WBH alone or in combination with FIR. Neither FIR nor WBH was effective in inhibiting the growth of adenomyosis, though WBH inhibited the growth of mammary tumours. The results suggest that mammary and uterine lesions do not always have a similar response/susceptibility to FIR. However, they indicate a promising protective role for FIR, especially WBH with FIR, in disorders of the uterine and other female genital tracts.
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The Effects of Different Schedules of Far-infrared Rays (FIR) on Uterine Adenomyosis in SHN Mice 2001 Volume 17 Issue 3 Pages 133-139 Details Abstract The SHN strain of virgin mice is characterized by a high susceptibility to both mammary tumours and uterine adenomyosis, which are considered to have similar etiological backgrounds. We previously studied the effects of different schedules of irradiation of far-infrared rays (FIR) and/or whole-body hyperthermia (WBH) with FIR on spontaneous mammary tumourigenesis in SHN mice. In the present study, the development and growth of uterine adenomyosis were examined in these mice. Continued exposure to FIR after 2 or 5 months of age and WBH between 2 and 4 months of age alone or in combination with FIR markedly inhibited mammary tumour development ; however, the development of adenomyosis was suppressed by exposure to FIR from the fetus and WBH alone or in combination with FIR. Neither FIR nor WBH was effective in inhibiting the growth of adenomyosis, though WBH inhibited the growth of mammary tumours. The results suggest that mammary and uterine lesions do not always have a similar response/susceptibility to FIR. However, they indicate a promising protective role for FIR, especially WBH with FIR, in disorders of the uterine and other female genital tracts. © Japanese Society for Thermal Medicine Favorites & Alerts Recently viewed articles Successor

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adenomyosis

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