The effectiveness of iron deficiency nutritional correction in patients with genital endometriosis accompanied by mild anemia

И. З. Гладчук, A. G. Volyanska, A.S. Lunko, T.A. Lunko
In: EMERGENCY MEDICINE · 2025 · vol. 21(7) , pp. 725–730 · doi:10.22141/2224-0586.21.7.2025.1965 · W4416427396
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Abstract

Background. Women with endometriosis are at higher risk of developing iron deficiency than those without endomet­riosis. The results of many studies indicate that iron deficiency should be considered during the initial diagnosis and subsequent treatment of endometriosis, since menstrual disorders with the simultaneous presence of endometrioid heterotopias are one of the factors for the development of anemia in women. The purpose was to study the effectiveness of nutritional correction of iron deficiency in patients with genital endometriosis accompanied by dysmenorrhea. Materials and methods. Endometriosis patients with mild anemia were prescribed nutritional correction of iron deficiency. In the study group (n = 34), women received a complex of microencapsulated iron pyrophosphate (14 mg) in liposomal form with folic acid (200 μg), vitamin B12 (2.5 μg) and vitamin C (80 mg), as well as a dietary supplement of lactoferrin at a dose of 250 mg per day for 2 months; in the comparison group (n = 32), the above-mentioned combination drug was administered without adding lactoferrin to the diet. The patients were assessed for the following indicators: hemoglobin level, erythrocyte count, ferritin levels, transferrin and total serum iron concentration before treatment and after 2 months. Results. Nutritional correction of iron deficiency in patients with endometriosis accompanied by mild anemia with the use of a complex of iron pyrophosphate and vitamins is not only effective, but also safe, because no side effects of diet therapy were recorded. Adding the dietary supplement lactoferrin to the iron-vitamin preparation improves restoration of the iron metabolism level and normalizes its key indicators: hemoglobin, ferritin and serum iron, and leads to a more significant increase in transferrin. It is also important that the mean corpuscular hemoglobin concentration in the study group reached normal, while in the comparison group, it only approached normal values. Conclusions. Lactoferrin in combination with an iron-vitamin complex can provide the most favorable conditions for the absorption of the required amount of iron against the background of a decrease in the inflammation and normalization of the microbiota. Due to its affinity for transferrin, lactoferrin participates in the full restoration of the proper level of iron metabolism, which is consistent with the data of other studies in recent years.

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endometriosisdysmenorrhea

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