The effectiveness of iron deficiency nutritional correction in patients with genital endometriosis accompanied by mild anemia

И. З. Гладчук, A. G. Volyanska, A.S. Lunko, T.A. Lunko
In: EMERGENCY MEDICINE · 2025 · vol. 21(7) , pp. 725–730 · doi:10.22141/2224-0586.21.7.2025.1965 · W4416427396
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Nutritional correction of iron deficiency with an iron-vitamin complex, especially with added lactoferrin, improved hemoglobin and iron metabolism indicators in women with endometriosis and mild anemia.

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This study evaluated the efficacy of nutritional iron correction in women with genital endometriosis and mild anemia, comparing a combination of microencapsulated iron pyrophosphate, vitamins, and lactoferrin against the same formulation without lactoferrin. Over a two-month period, researchers monitored hemoglobin, ferritin, transferrin, and serum iron levels to assess improvements in iron metabolism. The results indicated that adding lactoferrin significantly enhanced the normalization of these key indicators compared to the control group, with no reported side effects from the dietary therapy. This paper is centrally about endometriosis — specifically addressing the management of iron deficiency anemia associated with the condition through targeted nutritional supplementation.

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Abstract

Background. Women with endometriosis are at higher risk of developing iron deficiency than those without endomet­riosis. The results of many studies indicate that iron deficiency should be considered during the initial diagnosis and subsequent treatment of endometriosis, since menstrual disorders with the simultaneous presence of endometrioid heterotopias are one of the factors for the development of anemia in women. The purpose was to study the effectiveness of nutritional correction of iron deficiency in patients with genital endometriosis accompanied by dysmenorrhea. Materials and methods. Endometriosis patients with mild anemia were prescribed nutritional correction of iron deficiency. In the study group (n = 34), women received a complex of microencapsulated iron pyrophosphate (14 mg) in liposomal form with folic acid (200 μg), vitamin B12 (2.5 μg) and vitamin C (80 mg), as well as a dietary supplement of lactoferrin at a dose of 250 mg per day for 2 months; in the comparison group (n = 32), the above-mentioned combination drug was administered without adding lactoferrin to the diet. The patients were assessed for the following indicators: hemoglobin level, erythrocyte count, ferritin levels, transferrin and total serum iron concentration before treatment and after 2 months. Results. Nutritional correction of iron deficiency in patients with endometriosis accompanied by mild anemia with the use of a complex of iron pyrophosphate and vitamins is not only effective, but also safe, because no side effects of diet therapy were recorded. Adding the dietary supplement lactoferrin to the iron-vitamin preparation improves restoration of the iron metabolism level and normalizes its key indicators: hemoglobin, ferritin and serum iron, and leads to a more significant increase in transferrin. It is also important that the mean corpuscular hemoglobin concentration in the study group reached normal, while in the comparison group, it only approached normal values. Conclusions. Lactoferrin in combination with an iron-vitamin complex can provide the most favorable conditions for the absorption of the required amount of iron against the background of a decrease in the inflammation and normalization of the microbiota. Due to its affinity for transferrin, lactoferrin participates in the full restoration of the proper level of iron metabolism, which is consistent with the data of other studies in recent years.
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The effectiveness of iron deficiency nutritional correction in patients with genital endometriosis accompanied by mild anemia DOI: https://doi.org/10.22141/2224-0586.21.7.2025.1965Keywords: endometriosis, dysmenorrhea, iron deficiency anemia, iron pyrophosphate, lactoferrin, transferrinAbstract Background. Women with endometriosis are at higher risk of developing iron deficiency than those without endometriosis. The results of many studies indicate that iron deficiency should be considered during the initial diagnosis and subsequent treatment of endometriosis, since menstrual disorders with the simultaneous presence of endometrioid heterotopias are one of the factors for the development of anemia in women. The purpose was to study the effectiveness of nutritional correction of iron deficiency in patients with genital endometriosis accompanied by dysmenorrhea. Materials and methods. Endometriosis patients with mild anemia were prescribed nutritional correction of iron deficiency. In the study group (n = 34), women received a complex of microencapsulated iron pyrophosphate (14 mg) in liposomal form with folic acid (200 μg), vitamin B12 (2.5 μg) and vitamin C (80 mg), as well as a dietary supplement of lactoferrin at a dose of 250 mg per day for 2 months; in the comparison group (n = 32), the above-mentioned combination drug was administered without adding lactoferrin to the diet. The patients were assessed for the following indicators: hemoglobin level, erythrocyte count, ferritin levels, transferrin and total serum iron concentration before treatment and after 2 months. Results. Nutritional correction of iron deficiency in patients with endometriosis accompanied by mild anemia with the use of a complex of iron pyrophosphate and vitamins is not only effective, but also safe, because no side effects of diet therapy were recorded. Adding the dietary supplement lactoferrin to the iron-vitamin preparation improves restoration of the iron metabolism level and normalizes its key indicators: hemoglobin, ferritin and serum iron, and leads to a more significant increase in transferrin. It is also important that the mean corpuscular hemoglobin concentration in the study group reached normal, while in the comparison group, it only approached normal values. Conclusions. Lactoferrin in combination with an iron-vitamin complex can provide the most favorable conditions for the absorption of the required amount of iron against the background of a decrease in the inflammation and normalization of the microbiota. Due to its affinity for transferrin, lactoferrin participates in the full restoration of the proper level of iron metabolism, which is consistent with the data of other studies in recent years. Downloads References World Health Organization (WHO). Anaemia in women and children. Available from: https://www.who.int/data/gho/data/themes/topics/anaemia_in_women_and_children. Superti F. Lactoferrin from Bovine Milk: A Protective Companion for Life. Nutrients. 2020; 12(9):2562. doi: 10.3390/nu12092562.

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