⚙
AI-generated summary
by claude@2026-07, 2026-07-17
ⓘ
Placenta extract suppressed carrageenan-induced paw edema in rats by inhibiting serotonin, histamine, and prostaglandin E2, and also exhibited anti-exudative actions in a subacute inflammation model.
⚙
AI-generated deep summary
by claude@2026-07, 2026-07-17
· read from full text
ⓘ
This paper examined the anti-inflammatory mechanism of placenta extract by testing its effects on rat hind paw edema using the carrageenin-induced acute inflammation model. The authors report that placenta extract suppressed carrageenin edema, specifically inhibiting serotonin- and histamine-mediated edema and reducing prostaglandin involvement by suppressing arachidonic acid–mediated and prostaglandin E2–mediated responses. They also note that 7 days of post-treatment produced anti-exudative effects in a subacute inflammation model and discuss a mechanistic distinction from nonsteroidal anti-inflammatory drugs, with placenta extract possibly acting directly on prostaglandin E2. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.
Abstract
This study was aimed at examining the mechanism of anti-inflammatory actions of placenta extract. Placenta extract suppressed carrageenin edema. Carrageenin edema is a model of acute inflammation.Carrageenin edema is mediated by serotonin, histamine, bradykinin, arachidonic acid prostaglandin E1 and prostglandin E2. We investigated the effect of placenta extract on rat hind paw edema induced by carrageenin edemas chemical mediators.Placenta extract suppressed serotonin edema and histamine edema. Serotonin and histamine are regarded as allergy inducing factors. Moreover placenta extract had inhibitory effect on prostaglandins. Namely, placenta extract suppressed arachidonic acid-mediated edema and prostaglandin E2-mediated edema.Arachidonic acid is a precursor of prostaglandin E2.Arachidonic acid and prostaglandin E2 are regarded as edema enhancing factors. From these results, placenta extract had inhibitory effect on arachidonic acid and prostaglandin E2. Aspirin is a non-steroid anti-inflammtory drug. Non-steroid anti-inflammtory drugs have inhibitory effect of synthetic process from arachidonic acid to prostaglandin E2.Differently from the mechanism of non-steroid anti-inflammatory drugs, placenta extract might have direct suppressive actions on prostaglandin E2. On the other hand, inflammatory exudates are an important response in inflammation. The post-treatment of placenta extract for 7 days showed anti-exudative actions. This experiment is a model of subacute inflammation. The above results suggested that anti-inflammatory actions of placenta extract are very particular.
Full text
3,101 characters
· extracted from
oa-doi-fallback
· click to expand
プラセンタエキス中の活性成分の検討
炎症に対するプラセンタエキスの効果
1993 年 27 巻 3 号 p. 506-513
詳細
抄録
This study was aimed at examining the mechanism of anti-inflammatory actions of placenta extract. Placenta extract suppressed carrageenin edema. Carrageenin edema is a model of acute inflammation.
Carrageenin edema is mediated by serotonin, histamine, bradykinin, arachidonic acid prostaglandin E1 and prostglandin E2. We investigated the effect of placenta extract on rat hind paw edema induced by carrageenin edemas chemical mediators.
Placenta extract suppressed serotonin edema and histamine edema. Serotonin and histamine are regarded as allergy inducing factors. Moreover placenta extract had inhibitory effect on prostaglandins. Namely, placenta extract suppressed arachidonic acid-mediated edema and prostaglandin E2-mediated edema.
Arachidonic acid is a precursor of prostaglandin E2.
Arachidonic acid and prostaglandin E2 are regarded as edema enhancing factors. From these results, placenta extract had inhibitory effect on arachidonic acid and prostaglandin E2. Aspirin is a non-steroid anti-inflammtory drug. Non-steroid anti-inflammtory drugs have inhibitory effect of synthetic process from arachidonic acid to prostaglandin E2.
Differently from the mechanism of non-steroid anti-inflammatory drugs, placenta extract might have direct suppressive actions on prostaglandin E2. On the other hand, inflammatory exudates are an important response in inflammation. The post-treatment of placenta extract for 7 days showed anti-exudative actions. This experiment is a model of subacute inflammation. The above results suggested that anti-inflammatory actions of placenta extract are very particular.
Carrageenin edema is mediated by serotonin, histamine, bradykinin, arachidonic acid prostaglandin E1 and prostglandin E2. We investigated the effect of placenta extract on rat hind paw edema induced by carrageenin edemas chemical mediators.
Placenta extract suppressed serotonin edema and histamine edema. Serotonin and histamine are regarded as allergy inducing factors. Moreover placenta extract had inhibitory effect on prostaglandins. Namely, placenta extract suppressed arachidonic acid-mediated edema and prostaglandin E2-mediated edema.
Arachidonic acid is a precursor of prostaglandin E2.
Arachidonic acid and prostaglandin E2 are regarded as edema enhancing factors. From these results, placenta extract had inhibitory effect on arachidonic acid and prostaglandin E2. Aspirin is a non-steroid anti-inflammtory drug. Non-steroid anti-inflammtory drugs have inhibitory effect of synthetic process from arachidonic acid to prostaglandin E2.
Differently from the mechanism of non-steroid anti-inflammatory drugs, placenta extract might have direct suppressive actions on prostaglandin E2. On the other hand, inflammatory exudates are an important response in inflammation. The post-treatment of placenta extract for 7 days showed anti-exudative actions. This experiment is a model of subacute inflammation. The above results suggested that anti-inflammatory actions of placenta extract are very particular.
© 日本化粧品技術者会
Text is read by the "Ask this paper" AI Q&A widget below.
Extraction quality varies by source — PMC NXML preserves structure
cleanly, OA-HTML may include some navigation residue, and OA-PDF can
have broken hyphenation. The publisher copy
(via DOI)
is the canonical version.