Research Article Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues

Christina D. Drenberg, Ra Livingston, Ren Chen, Patricia A. Kruk, Santo V. Nicosia
2013 · W7100866527
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This study investigated the expression of semaphorin 3F, neuropilin-2, and neuropilin-1 in normal ovaries, benign cystadenomas, and epithelial ovarian cancer tissues.

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Abstract

While semaphorins and their receptors appear to play a role in tumor carcinogenesis, little is known about the role of semaphorin 3F (S3F) in epithelial ovarian cancer (EOC) development. Therefore, we sought to determine the clinical relationship between S3F and its receptors, neuropilin-2 (NP-2) and neuropilin-1 (NP-1) with EOC progression. We analyzed the immunohistological expression of S3F, NP-2, and NP-1 in clinical specimens of normal ovaries (N), benign cystadenomas (Cy), well-differentiated

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