Absence of association between a functional polymorphism of ALOX15 gene and infertility in endometriosis

Bruno Borghese, Vanessa Gayet, Jean-Daniel Chiche, Déwi Vernerey, Dominique de Ziegler, Catherine Bonaiti-Pellié, Charles Chapron
Fertility and sterility · 2009 · doi:10.1016/j.fertnstert.2008.05.039 · PMID:18692814
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Abstract

The aim of the present study, involving 463 women of reproductive age, was to evaluate for the first time the relationship between endometriosis, endometriosis-related infertility, and a recently described functional polymorphism in the ALOX15 gene, reported to be essential for implantation. In our study population, ALOX15 -292 C/T was not correlated either with the risk of developing an endometriosis or with the risk of infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Arachidonate 15-Lipoxygenase Endometriosis Infertility, Female Polymorphism, Single Nucleotide Arachidonate 15-Lipoxygenase Case-Control Studies Endometriosis Female Gene Frequency Gene Frequency Genetic Predisposition to Disease Genetic Predisposition to Disease Humans Infertility, Female Polymorphism, Single Nucleotide Risk Factors

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