Clinical Observation of Comparing the Efficacy of Three-drug Regimens Containing Olanzapine/Dexamethasone in Preventing Hyperemetic Chemotherapy-induced Nausea and Vomiting (CINV)

Abstract A randomized, open-label, parallel-controlled study was conducted to compare the efficacy of two kind of three-drug Regimens containing olanzapine/dexamethasone for the prevention of CINV induced by hyperemetic chemotherapy. The results showed that there was no significant difference in the complete response rates of nausea and vomiting between the two groups. However, the anxiety, depression and sleep quality of the patients in the olanzapine group were improved. It was concluded that the three-drug antiemetic regimen of "olanzapine +palonosetron+fosaprepitant" could effectively prevent CINV caused by hyperemetic chemotherapy, and its effect was similar to that of the antiemetic regimen containing dexamethasone. In addition, the anxiety, depression and sleep disorders of patients in the olanzapine group were all improved to different degrees.Our study has provided a theoretical basis for the clinical application of the three-drug regimen of "dexamethasone removal".