Effect of ginsenoside Rg3 on micro-vessel density of endometriosis rats

Objective To observe the effect of ginsenoside Rg3 on microvessel density (MVD) of endometriosis in vivo. Methods Endometriosis models of Wistar rats were established referring to Jones methods. The endometriosis rats were treated with either ginsenoside Rg3 or gestrinone, compared with untreated rats. MVD was immunohistochemically determined (SABC technique) at 2, 4, 6 and 8 weeks of treatment, respectively. Results Compared to the untreated rats, MVD in endometriosis were decreased remarkably after ginsenoside Rg3 treating for 2, 4, 6 or 8 weeks (P0.05). However, significant difference was not observed in rats treated with gestrinone (P0.05). Furthermore, the decrease was more remarkable when treated longer with ginsenoside Rg3 (P0.05). Conclusions Ginsenoside Rg3 suppresses antiangiogenesis in endometriosis tissue in vivo. Ginsenoside Rg3 may be a potential drug for treating endometriosis.