Recurrent Miscarriage and the Underestimated Role of Sperm DNA Damage: Time to Rethink the Male Factor

Recurrent Miscarriage and the Underestimated Role of Sperm DNA Damage: Time to Rethink the Male Factor | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 7 November 2025 V1 Latest version Share on Recurrent Miscarriage and the Underestimated Role of Sperm DNA Damage: Time to Rethink the Male Factor Author : Hiba Al-azeez [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.176249531.10758424/v1 217 views 84 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Recurrent miscarriage (RM), defined as two or more consecutive pregnancy losses, affects 1–2% of reproductive-age couples and remains idiopathic in up to 50% of cases. Despite the growing emphasis on maternal evaluation, the role of male factors, particularly sperm DNA fragmentation (SDF), is often neglected. Emerging evidence indicates that sperm DNA damage contributes significantly to impaired embryonic development and pregnancy loss. This narrative review explores the biological mechanisms linking SDF to RM, summarizes key studies, examines the clinical implications, and calls for a paradigm shift toward a more inclusive, couple-based approach in RM investigations and management. Supplementary Material File (recurrent miscarriage hiba adjusted.docx) Download 29.57 KB Information & Authors Information Version history V1 Version 1 07 November 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords fetal medicine: fetal physiology general gynaecology genetics infertility: diagnosis in male miscarriage miscarriage: recurrent reproductive science: implantation Authors Affiliations Hiba Al-azeez [email protected] Princess Royal University Hospital Library View all articles by this author Metrics & Citations Metrics Article Usage 217 views 84 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Hiba Al-azeez. Recurrent Miscarriage and the Underestimated Role of Sperm DNA Damage: Time to Rethink the Male Factor. Authorea . 07 November 2025. DOI: https://doi.org/10.22541/au.176249531.10758424/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.176249531.10758424/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'9feaa2b2497a300f',t:'MTc3OTI3MjcwNg=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();