Statin Use Impairs Cognition and is Associated with Voxel-wise and Network Based Grey Matter Atrophy: Findings from a Cohort Study

Statin Use Impairs Cognition and is Associated with Voxel-wise and Network Based Grey Matter Atrophy: Findings from a Cohort Study | medRxiv /* */ /* */ <!-- <!-- /*! * yepnope1.5.4 * (c) WTFPL, GPLv2 */ (function(a,b,c){function d(a){return"[object Function]"==o.call(a)}function e(a){return"string"==typeof a}function f(){}function g(a){return!a||"loaded"==a||"complete"==a||"uninitialized"==a}function h(){var a=p.shift();q=1,a?a.t?m(function(){("c"==a.t?B.injectCss:B.injectJs)(a.s,0,a.a,a.x,a.e,1)},0):(a(),h()):q=0}function i(a,c,d,e,f,i,j){function k(b){if(!o&&g(l.readyState)&&(u.r=o=1,!q&&h(),l.onload=l.onreadystatechange=null,b)){"img"!=a&&m(function(){t.removeChild(l)},50);for(var d in y[c])y[c].hasOwnProperty(d)&&y[c][d].onload()}}var j=j||B.errorTimeout,l=b.createElement(a),o=0,r=0,u={t:d,s:c,e:f,a:i,x:j};1===y[c]&&(r=1,y[c]=[]),"object"==a?l.data=c:(l.src=c,l.type=a),l.width=l.height="0",l.onerror=l.onload=l.onreadystatechange=function(){k.call(this,r)},p.splice(e,0,u),"img"!=a&&(r||2===y[c]?(t.insertBefore(l,s?null:n),m(k,j)):y[c].push(l))}function j(a,b,c,d,f){return q=0,b=b||"j",e(a)?i("c"==b?v:u,a,b,this.i++,c,d,f):(p.splice(this.i++,0,a),1==p.length&&h()),this}function k(){var a=B;return a.loader={load:j,i:0},a}var l=b.documentElement,m=a.setTimeout,n=b.getElementsByTagName("script")[0],o={}.toString,p=[],q=0,r="MozAppearance"in l.style,s=r&&!!b.createRange().compareNode,t=s?l:n.parentNode,l=a.opera&&"[object Opera]"==o.call(a.opera),l=!!b.attachEvent&&!l,u=r?"object":l?"script":"img",v=l?"script":u,w=Array.isArray||function(a){return"[object Array]"==o.call(a)},x=[],y={},z={timeout:function(a,b){return b.length&&(a.timeout=b[0]),a}},A,B;B=function(a){function b(a){var a=a.split("!"),b=x.length,c=a.pop(),d=a.length,c={url:c,origUrl:c,prefixes:a},e,f,g;for(f=0;f<d;f++)g=a[f].split("="),(e=z[g.shift()])&&(c=e(c,g));for(f=0;f<b;f++)c=x[f](c);return c}function g(a,e,f,g,h){var i=b(a),j=i.autoCallback;i.url.split(".").pop().split("?").shift(),i.bypass||(e&&(e=d(e)?e:e[a]||e[g]||e[a.split("/").pop().split("?")[0]]),i.instead?i.instead(a,e,f,g,h):(y[i.url]?i.noexec=!0:y[i.url]=1,f.load(i.url,i.forceCSS||!i.forceJS&&"css"==i.url.split(".").pop().split("?").shift()?"c":c,i.noexec,i.attrs,i.timeout),(d(e)||d(j))&&f.load(function(){k(),e&&e(i.origUrl,h,g),j&&j(i.origUrl,h,g),y[i.url]=2})))}function h(a,b){function c(a,c){if(a){if(e(a))c||(j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}),g(a,j,b,0,h);else if(Object(a)===a)for(n in m=function(){var b=0,c;for(c in a)a.hasOwnProperty(c)&&b++;return b}(),a)a.hasOwnProperty(n)&&(!c&&!--m&&(d(j)?j=function(){var a=[].slice.call(arguments);k.apply(this,a),l()}:j[n]=function(a){return function(){var b=[].slice.call(arguments);a&&a.apply(this,b),l()}}(k[n])),g(a[n],j,b,n,h))}else!c&&l()}var h=!!a.test,i=a.load||a.both,j=a.callback||f,k=j,l=a.complete||f,m,n;c(h?a.yep:a.nope,!!i),i&&c(i)}var i,j,l=this.yepnope.loader;if(e(a))g(a,0,l,0);else if(w(a))for(i=0;i (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0];var j=d.createElement(s);var dl=l!='dataLayer'?'&l='+l:'';j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;j.type='text/javascript';j.async=true;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-P4HH5NV'); Skip to main content Home About Submit ALERTS / RSS Search for this keyword Advanced Search Withdrawn Statin Use Impairs Cognition and is Associated with Voxel-wise and Network Based Grey Matter Atrophy: Findings from a Cohort Study Shan Yao Liew , Ashwati Vipin , Yi Jin Leow , Pricilia Tanoto , Gurveen Kaur Sandhu , Gursimar Bhalla , Kiirtaara Aravindhan , Smriti Ghildiyal , Faith Phemie Hui En Lee , View ORCID Profile Fatin Zahra Zailan , Adnan Azam Mohammed , View ORCID Profile Seyed Ehsan Saffari , John Chambers , Nagaendran Kandiah doi: https://doi.org/10.1101/2025.05.09.25327347 Shan Yao Liew 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 BSocSc Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ashwati Vipin 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site Yi Jin Leow 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 PGDip Find this author on Google Scholar Find this author on PubMed Search for this author on this site Pricilia Tanoto 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 MPsychSc Find this author on Google Scholar Find this author on PubMed Search for this author on this site Gurveen Kaur Sandhu 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site Gursimar Bhalla 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 BSc Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kiirtaara Aravindhan 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site Smriti Ghildiyal 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 BA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Faith Phemie Hui En Lee 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 BPsych Find this author on Google Scholar Find this author on PubMed Search for this author on this site Fatin Zahra Zailan 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 BBiomedSc Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Fatin Zahra Zailan Adnan Azam Mohammed 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 BEng Find this author on Google Scholar Find this author on PubMed Search for this author on this site Seyed Ehsan Saffari 2 Duke-NUS Medical School, National University of Singapore , Singapore 3 Department of Neurology, National Neuroscience Institute , Singapore PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Seyed Ehsan Saffari John Chambers 4 Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 5 Department of Epidemiology and Biostatistics, School of Public Health Faculty of Medicine, Imperial College London , London, UK PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site Nagaendran Kandiah 1 Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 6 Neuroscience and Mental Health Programme, Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore 308232 7 National Healthcare Group, 3 Fusionopolis Link , Nexus @ One-North, Singapore 138543 FRCP Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: nagaendran_kandiah{at}ntu.edu.sg Abstract Info/History Metrics Preview PDF Withdrawal Statement The authors have withdrawn this manuscript because they are reanalyzing the project. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author. Competing Interest Statement The authors have declared no competing interest. Funding Statement This study received funding support from the Strategic Academic Initiative grant (SP1CLNT900-NTU-A630-PJ-03INP001400A630) from the Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, National Medical Research Council, Singapore under its Clinician Scientist Award (MOH-CSAINV18nov-0007), Ministry of Education Start-up Grant, Ministry of Education Academic Research Fund Tier 1 (RT02/21) and Ministry of Education Science of Learning grant (MOESOL2022-0002). Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: All participants provided informed consent, and the study was approved by the institutional ethics board(IRB-2021-1036). I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Footnotes ↵ * Joint First Authors Copyright The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. View the discussion thread. Back to top Previous Next Posted July 10, 2025. Download PDF Email Thank you for your interest in spreading the word about medRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. 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Share Statin Use Impairs Cognition and is Associated with Voxel-wise and Network Based Grey Matter Atrophy: Findings from a Cohort Study Shan Yao Liew , Ashwati Vipin , Yi Jin Leow , Pricilia Tanoto , Gurveen Kaur Sandhu , Gursimar Bhalla , Kiirtaara Aravindhan , Smriti Ghildiyal , Faith Phemie Hui En Lee , Fatin Zahra Zailan , Adnan Azam Mohammed , Seyed Ehsan Saffari , John Chambers , Nagaendran Kandiah medRxiv 2025.05.09.25327347; doi: https://doi.org/10.1101/2025.05.09.25327347 Share This Article: Copy Citation Tools Statin Use Impairs Cognition and is Associated with Voxel-wise and Network Based Grey Matter Atrophy: Findings from a Cohort Study Shan Yao Liew , Ashwati Vipin , Yi Jin Leow , Pricilia Tanoto , Gurveen Kaur Sandhu , Gursimar Bhalla , Kiirtaara Aravindhan , Smriti Ghildiyal , Faith Phemie Hui En Lee , Fatin Zahra Zailan , Adnan Azam Mohammed , Seyed Ehsan Saffari , John Chambers , Nagaendran Kandiah medRxiv 2025.05.09.25327347; doi: https://doi.org/10.1101/2025.05.09.25327347 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Area Neurology Subject Areas All Articles Addiction Medicine (567) Allergy and Immunology (863) Anesthesia (297) Cardiovascular Medicine (4411) Dentistry and Oral Medicine (443) Dermatology (380) Emergency Medicine (606) Endocrinology (including Diabetes Mellitus and Metabolic Disease) (1505) Epidemiology (15205) Forensic Medicine (30) Gastroenterology (1119) Genetic and Genomic Medicine (6574) Geriatric Medicine (666) Health Economics (994) Health Informatics (4511) Health Policy (1365) Health Systems and Quality Improvement (1608) Hematology (537) HIV/AIDS (1263) Infectious Diseases (except HIV/AIDS) (15903) Intensive Care and Critical Care Medicine (1103) Medical Education (620) Medical Ethics (144) Nephrology (666) Neurology (6573) Nursing (345) Nutrition (998) Obstetrics and Gynecology (1139) Occupational and Environmental Health (954) Oncology (3319) Ophthalmology (968) Orthopedics (369) Otolaryngology (420) Pain Medicine (435) Palliative Medicine (129) Pathology (662) Pediatrics (1689) Pharmacology and Therapeutics (691) Primary Care Research (710) Psychiatry and Clinical Psychology (5422) Public and Global Health (9205) Radiology and Imaging (2191) Rehabilitation Medicine and Physical Therapy (1367) Respiratory Medicine (1191) Rheumatology (593) Sexual and Reproductive Health (709) Sports Medicine (529) Surgery (709) Toxicology (99) Transplantation (288) Urology (265) (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'9feaa189cea206e7',t:'MTc3OTI3MjY1OQ=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();