Infertile Patients with Endometriosis Benefit from Surgery

In: 50 Big Debates in Reproductive Medicine · 2021 · pp. 111–113 · doi:10.1017/9781108986373.043 · W3215039138
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Endometriosis negatively impacts IVF outcomes and surgical treatment of endometriosis is associated with improved spontaneous pregnancy rates and pain relief.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

This chapter discusses how “unexplained infertility” may in part reflect missed diagnoses of endometriosis due to limited diagnostic laparoscopy and frequent referral directly to IVF, and it frames the question of whether properly diagnosing and treating endometriosis could enable conception without IVF after failed IVF. Drawing on recent and earlier evidence, it reports that endometriosis surgery can improve reproductive outcomes, including not only pain relief but also spontaneous pregnancies, while noting that endometriosis itself can negatively affect ovarian reserve. The chapter emphasizes a key caveat that surgery should be performed with utmost care using the latest technologies and by well-trained specialists because the disease and surgical intervention both relate to ovarian reserve. This paper is centrally about endometriosis — it argues that infertile patients with endometriosis benefit from surgical treatment.

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Abstract

The increased number of so called ‘unexplained infertility’ hides a high number of not diagnosed endometriosis due to the systematic omission of a diagnostic laparoscopy in the exploration of the infertile patients and a policy of a liberal referral to IVF programs. The question of patients after failed IVF, ‘Could I conceive without IVF if my endometriosis was properly diagnosed and treated?’ should stimulate a critical evaluation of the treatment policy. Endometriosis negatively affects reproductive outcomes after IVF treatments. Recent and old data clearly demonstrates the positive effect of endometriosis surgery not only in the relief of pain but also for obtaining spontaneous pregnancies. As the disease by itself negatively affects the ovarian reserve, utmost care should be while performing the surgery using latest technologies and it should be performed by well-trained surgeons with the required expertise.
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- 50 Big Debates in Reproductive Medicine - Series page - 50 Big Debates in Reproductive Medicine - Copyright page - Contents - Contributors - Foreword - Introduction - Section I Limits for IVF - Section II IVF Add-ons - Section III The Best Policy - 14A IVF Should Be First-Line Treatment for Unexplained Infertility of Two Years Duration - 14B IVF Should Be First-Line Treatment for Unexplained Infertility of Two Years Duration - 15A Single Embryo Transfer Should Be Performed in All IVF Cycles - 15B Single-Embryo Transfer Should Be Performed in All IVF Cycles - 16A The Freezing of All Embryos Should Be Used for All IVF Cycles - 16B The Freezing of All Embryos Should Be Used for All IVF Cycles - 17A Luteal-Phase Support Should Be Stopped at the Time of a Positive Pregnancy Test - 17B Luteal Phase Support Should Be Stopped at the Time of a Positive Pregnancy Test - 18A A Natural Cycle Is the Best Protocol for Frozen Embryo Replacement - 18B A Natural Cycle Is the Best Protocol for Frozen Embryo Replacement - 19A All Pregnancies Conceived by IVF Should Be Delivered by Caesarean Section - 19B All Pregnancies Conceived by IVF Should Be Delivered by Caesarean Section - 20A Endometriosis Should Be Suppressed for 6–12 Weeks before Frozen Embryo Transfer - 20B Endometriosis Should Be Suppressed for 6–12 Weeks before Frozen Embryo Transfer - 21A Infertile Patients with Endometriosis Benefit from Surgery - 21B Infertile Patients with Endometriosis Benefit from Surgery - 22A Intramural Fibroids Greater than 4 cm in Diameter Should Be Removed to Aid Fertility - 22B Intramural Fibroids Greater than 4 cm in Diameter Should Be Removed to Aid Fertility - 23A All Infertile Women with a Uterine Septum Should Have a Surgical Removal - 23B All Infertile Women with a Uterine Septum Should Have a Surgical Removal - Section IV Embryology - Section V Ethics and Statistics - Section VI Male-factor Infertility - Section VII Genetics - Section VIII Ovarian Stimulation - Section IX Hormones and the Environment - Index - References For from Section III - The Best Policy Published online by Cambridge University Press: 25 November 2021 Book contents - 50 Big Debates in Reproductive Medicine - Series page - 50 Big Debates in Reproductive Medicine - Copyright page - Contents - Contributors - Foreword - Introduction - Section I Limits for IVF - Section II IVF Add-ons - Section III The Best Policy - 14A IVF Should Be First-Line Treatment for Unexplained Infertility of Two Years Duration - 14B IVF Should Be First-Line Treatment for Unexplained Infertility of Two Years Duration - 15A Single Embryo Transfer Should Be Performed in All IVF Cycles - 15B Single-Embryo Transfer Should Be Performed in All IVF Cycles - 16A The Freezing of All Embryos Should Be Used for All IVF Cycles - 16B The Freezing of All Embryos Should Be Used for All IVF Cycles - 17A Luteal-Phase Support Should Be Stopped at the Time of a Positive Pregnancy Test - 17B Luteal Phase Support Should Be Stopped at the Time of a Positive Pregnancy Test - 18A A Natural Cycle Is the Best Protocol for Frozen Embryo Replacement - 18B A Natural Cycle Is the Best Protocol for Frozen Embryo Replacement - 19A All Pregnancies Conceived by IVF Should Be Delivered by Caesarean Section - 19B All Pregnancies Conceived by IVF Should Be Delivered by Caesarean Section - 20A Endometriosis Should Be Suppressed for 6–12 Weeks before Frozen Embryo Transfer - 20B Endometriosis Should Be Suppressed for 6–12 Weeks before Frozen Embryo Transfer - 21A Infertile Patients with Endometriosis Benefit from Surgery - 21B Infertile Patients with Endometriosis Benefit from Surgery - 22A Intramural Fibroids Greater than 4 cm in Diameter Should Be Removed to Aid Fertility - 22B Intramural Fibroids Greater than 4 cm in Diameter Should Be Removed to Aid Fertility - 23A All Infertile Women with a Uterine Septum Should Have a Surgical Removal - 23B All Infertile Women with a Uterine Septum Should Have a Surgical Removal - Section IV Embryology - Section V Ethics and Statistics - Section VI Male-factor Infertility - Section VII Genetics - Section VIII Ovarian Stimulation - Section IX Hormones and the Environment - Index - References The increased number of so called ‘unexplained infertility’ hides a high number of not diagnosed endometriosis due to the systematic omission of a diagnostic laparoscopy in the exploration of the infertile patients and a policy of a liberal referral to IVF programs. The question of patients after failed IVF, ‘Could I conceive without IVF if my endometriosis was properly diagnosed and treated?’ should stimulate a critical evaluation of the treatment policy. Endometriosis negatively affects reproductive outcomes after IVF treatments. Recent and old data clearly demonstrates the positive effect of endometriosis surgery not only in the relief of pain but also for obtaining spontaneous pregnancies. As the disease by itself negatively affects the ovarian reserve, utmost care should be while performing the surgery using latest technologies and it should be performed by well-trained surgeons with the required expertise. - Type - Chapter - Information - 50 Big Debates in Reproductive Medicine , pp. 111 - 113Publisher: Cambridge University PressPrint publication year: 2021 Kitajima, M, Defrere, S, Dolmans, MM, et al. Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis. Fertil Steril. 2011;96:685–91.CrossRefGoogle ScholarPubMed Duffy, JM, Arambage, K, Correa, FJ, et al. Laparoscopic surgery for endometriosis. Cochrane Database Syst Rev. 2014;4:CD011031.Google Scholar Muteshi, CM, Ohuma, EO, Child, T, Becker, CM. The effect of endometriosis on live birth rate and other reproductive outcomes in ART cycles: a cohort study. Hum Reprod Open. 2018 Sept 29;2018(4).CrossRefGoogle ScholarPubMed Opøien, HK, Fedorcsak, P, Byholm, T, Tanbo, T. Complete surgical removal of minimal and mild endometriosis improves outcome of subsequent IVF/ICSI treatment. Reprod Biomed. 2011;23:389.e95.CrossRefGoogle ScholarPubMed Barri, PN, Coroleu, B, Tur, R, Barri-Soldevila, PN, Rodríguez, I.Endometriosis-associated infertility: surgery and IVF, a comprehensive therapeutic approach. Reprod Biomed. 2010 Aug;21(2):179–85.CrossRefGoogle ScholarPubMed Accessibility compliance for the HTML of this chapter is currently unknown and may be updated in the future. 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endometriosisinfertility

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