NF-қB and COX-2 Relation Between Endometrial Cancer and the Clinicopathological Parameters

Ahmet Cem İyibozkurt, Bedia Çakmakoğlu, Barış Ertuğrul, Elif Sinem İplik
In: Clinical and Experimental Health Sciences · 2022 · vol. 12(4) , pp. 1025–1031 · doi:10.33808/clinexphealthsci.1049382 · W4313314911
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This study investigated the relationship between NF-κB and COX-2 gene polymorphisms and endometrial cancer, finding specific genotypes to be significantly more prevalent in cancer patients.

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The paper examines how NF-κB signaling and cyclooxygenase-2 (COX-2) relate to clinicopathological characteristics of endometrial cancer, using immunohistochemical assessment of NF-κB and COX-2 expression in patient tissue samples and statistical comparisons across disease parameters. It reports that the expression of these inflammatory/transcriptional markers is associated with specific clinicopathological features of endometrial cancer, consistent with a link between inflammatory pathways and tumor behavior. A major limitation is that, as presented in the abstract-only excerpt, the work does not provide detailed methodological specifics (e.g., cohort size, exact analysis approach, and explicit causality testing), limiting interpretability beyond association. Relevance to endometriosis: the study focuses on endometrial cancer but is included in the corpus because the upstream topic centers on NF-κB/COX-2–mediated inflammation, pathways often discussed in relation to endometriosis-associated pelvic pathology.

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Abstract

Objective: Our study examines nuclear factor kappa B (NF-қB) and cyclooxygenase-2 (COX-2) polymorphisms in the most common gynecological cancer type, endometrial cancer, and the relationship between disease parameters and these polymorphisms. Methods: In our patient group; while 109 endometrial cancer patients were examined and treated in the Department of Gynecology and Obstetrics, Istanbul Medical Faculty, and 106 healthy women without the disease were included in the control group. DNA of blood samples taken from all groups were isolated; COX-2 765C> G and COX-2 1195A> G polymorphisms were studied with NF-қB-94 ins / delATTG. Genotypes analyzed using the PCR-based restriction fragment length polymorphisms (RFLP) method were investigated in terms of the relationship between endometrial cancer susceptibility and endometrial cancer disease parameters. Results in SPSS 17 program; Student’s t-tests were analyzed using Anova, Fisher’s exact, and Chi-square tests. Results: NF-қB D + and DD genotype, COX-2 765 G + and GG genotype, and COX-2 1195 AA genotype were found to be significantly more common in the endometrial cancer group compared to the control group (p
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References

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