Enhancement of the Antioxidant Activity of Hedysari Radix Particles Dispersion via ZIF-8/PEG Surface Co-Adsorption

Herein, a co-adsorption modification based on ZIF-8 was introduced with the contribution of PEG package to enhance the antioxidant potency of the Hedysari Radix disperse particles. In the solution system containing 15% ethanol, the rough surface of the original Hedysari Radix disperse particles (HRE) was improved by the typical co-adsorption modification with ZIF-8 (HRE@ZIF-8 3) and further smoothed by the package of PEG (HRE@ZIF-8@PEG 3). The co-adsorption modifications including ZIF-8 only, PEG only, and ZIF-8 with PEG were all studied in the solution system. In particular, the modification combined both the PEG package and suitable amount of ZIF-8 achieved the most significant enhancement of the CAT activity as well as the T-AOC value. HRE@ZIF-8@PEG 3 alleviated the oxidative stress upon C. elegans and extended the survival time. This work suggested meaningful co-adsorption modification for improving the potency of the medicinal plant resources.