Growth-inhibitory effects of a mineralized extract from the red marine algae, Lithothamnion calcareum, on Ca2+-sensitive and Ca2+-resistant human colon carcinoma cells

Muhammad N. Aslam, Narasimharao Bhagavathula, Tejaswi Paruchuri, Xin Hu, Subhas Chakrabarty, James Varani
In: Cancer Letters · 2009 · vol. 283(2) , pp. 186–192 · doi:10.1016/j.canlet.2009.03.037 · PMID:19394137 · W2149862581
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Abstract

Proliferation and differentiation were assessed in a series of human colon carcinoma cell lines in response to a mineral-rich extract derived from the red marine algae, Lithothamnion calcareum. The extract contains 12% Ca2+, 1% Mg2+, and detectable amounts of 72 trace elements, but essentially no organic material. The red algae extract was as effective as inorganic Ca2+ alone in suppressing growth and inducing differentiation of colon carcinoma cells that are responsive to a physiological level of extracellular Ca2+ (1.4mM). However, with cells that are resistant to Ca2+ alone, the extract was still able to reduce proliferation and stimulate differentiation.

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