In Vitro Fertilization

Susan Heyner, Michael Tucker
In: Developmental Biology Protocols · 2003 · vol. 137 , pp. 277–300 · doi:10.1385/1-59259-066-7:277 · PMID:10948545 · W2427307083
article OA: closed CC0
View on OpenAlex View on PubMed View at publisher

Abstract

Almost 20 years ago, the first successful in vitro fertilization (IVF) and embryo transfer (ET) was described by Steptoe and Edwards (1). This engendered a great deal of excitement and in hindsight, we can say that it marked the movement of reproductive medicine for the treatment of infertility from the operating room into the laboratory. The first successful IVF pregnancy was achieved in a woman with blocked fallopian tubes, and consequently, IVF-ET was viewed initially as a treatment for tubal obstruction. Within a short time, these techniques were adopted for the treatment of infertility of unknown origin, for severe male factor infertility, endometriosis, and immunological infertility. More recently, these boundaries have been enlarged to include treatment of women with premature ovarian failure and postmenopausal patients using donated oocytes. In addition, azoospermic men have been successfully treated, and in conjunction with preimplantation diagnosis, IVF has been applied to couples in which a severe genetic defect may be eliminated by screening embryos before transfer to the uterus.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

References (11)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK