Pregnancy Rate After Myomectomy and Associated Factors Among Reproductive Age Women Who Had Myomectomy at Saint Paul’s Hospital Millennium Medical College, Addis Ababa: Retrospective Cross-sectional Study.

Pregnancy Rate After Myomectomy and Associated Factors Among Reproductive Age Women Who Had Myomectomy at Saint Paul’s Hospital Millennium Medical College, Addis Ababa: Retrospective Cross-sectional Study. | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Pregnancy Rate After Myomectomy and Associated Factors Among Reproductive Age Women Who Had Myomectomy at Saint Paul’s Hospital Millennium Medical College, Addis Ababa: Retrospective Cross-sectional Study. meseret olana jeldu, Tadios Mekonnen asress, temesgen tantu arusi, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-250064/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 28 Nov, 2021 Read the published version in International Journal of Reproductive Medicine → Version 1 posted You are reading this latest preprint version Abstract Introduction: Uterine myoma occurs in 20-50% of reproductive age women. Uterine myomas may be associated with 5-10% of cases of infertility, but it is the sole cause or factor in only 2-3% of all infertility cases. Myomectomy is surgery done to remove myoma regardless of the methods. Objective : to assess impact of myomectomy on pregnancy rate and associated factors among reproductive age women who had myomectomy at St. Paul’s Hospital Millennium Medical College, in Addis Ababa. Methodology : Hospital based retrospective cross-sectional study was conducted to determine pregnancy rate after myomectomy & its associated factors. Patients who had myomectomy in SPHMMC from September, 2012 to September, 2017 were enrolled. Information was retrieved from hospital records & phone interviews with the patients. The strength of statistical association was measured by adjusted odds ratios and 95% confidence intervals. Statistical significance was declared at p-value 35 years were 0.31 times less likely to get pregnant after surgery than those ages 20-25 years [AOR=0.31(95%CI: 0.29-0.54)]. People with no infertility before surgery were 1.19 times more likely to be pregnant after surgery than those with unexplained infertility before the surgery [AOR=1.19(95%CI: 1.06-1.57)]. People with two uterine incisions were 0.06 times less likely [AOR=0.06(95%CI: 0.043-0.51)] while those with three or more than three incisions were 0.02 times less likely [AOR=0.02(95%CI: 0.002-0.22)] to get pregnant compared with those with one incision on uterine wall Conclusion : Age, number of incision and infertility before surgery were significantly associated with rate of pregnancy after myomectomy. Sexual & Reproductive Medicine Myomectomy infertility pregnancy myoma unexplained infertility Figures Figure 1 Plain English Myoma is one of the commonest abnormal uterine enlargement occurs in reproductive age women. It is commonly associated with infertility but literatures in 2–3% of cases associate mere presence of myoma as cause of infertility. The aim of this study is to assess the rate of pregnancy after myomectomy for women having myoma and its associated factors. The retrospective study was done to retrieve 180 women cards for whom myomectomy done in saint poul’s millennium medical college from September, 2012 to September, 2017. In addition to card retrieval, phone interviews done with selected women. From cards of individuals history as well as surgical techniques selected like number of uterine incisions, location of myoma and incisions, indications for surgery, previous history of infertility and other parameters taken to determine the rate of pregnancy. Hundred eighty women participated in the study and 52.2% got pregnant. Moreover, the younger the age the higher the chance of getting pregnancy. Previous history of infertility before myomectomy and number of uterine incisions have influence on the rate of pregnancy. Finally, the study showed that the age, number of uterine incisions and previous history of infertility are conditions which have influence on the rate of pregnancy after myomectomy Introduction Uterine myoma is a monoclonal, benign tumor arising from smooth muscles of the uterus. It occurs in 20–50% of reproductive age women and can be identified by ultrasound in approximately 80% of African-American and 70% of white American women by the time they reach menopause( 1 – 3 ). These tumors are classified based on their location and direction of growth: submucous, Intramural & subserous. Submucous myomas are proximate to the endometrium and grow toward and bulge into the endometrial cavity ( 1 , 4 – 6 ). The role of myomas as a causative factor in infertility remains controversial. It has been proposed that myomas interfere sperm transport, cause cervical and/or tubal blockage, distort endometrial cavity, or may cause inflammation to endometrium or secretion of vasoactive substances ( 2 ). According to AFS guideline for practice, myomas may be associated with 5 to 10% of infertility but it is sole factor in only 2 to3% of all infertility cases. Even though myomectomy is the recommended treatment for symptomatic myomas among women wishing to preserve their fertility, the fertility performance of the women after this surgery is not thoroughly studied & detailed. It may also be associated with infertility due to extensive adhesion causing tubal blockage and intrauterine adhesions (IUAs) if endometrium is breached during surgery( 1 – 3 ). Myomectomy is found to significantly increase conception rate in women with myomas as a sole factor of infertility. The conception rate following myomectomy ranged from 25 to 77% in available retrospective studies( 3 ). In different retrospective study done at different hospitals and country showed improvement in fertility after myomectomy. Moreover, Age of the women, presence of pelvic adhesion and the presence of concomitant history of unexplained infertility have negative influence on chance of conception after myomectomy. There was no significant difference in pregnancy rate according to whether the uterine cavity is entered or not, preoperative size, location and size of myoma(s)( 2 , 3 , 7 – 9 ). Many of the women with symptomatic myoma are in reproductive age group and need for future fertility ( 2 , 7 , 10 – 12 ). There is shortage of data done in this area of interest as well as there is no research done on fertility performance after myomectomy in Ethiopia. For this reason and due to uncertainty of effect of myomectomy on pregnancy rate, physicians always face dilemma in counseling and management options of women with symptomatic myomas who need to conserve their fertility. Materials And Methods 2.1 study area, design, and populations. Institution based cross sectional study was undertaken at St. Paul’s Hospital Millennium Medical College, in Addis Ababa, the capital city of Ethiopia from November 1, 2018 to December 30, 2018. It is the hospital with highest delivery rate and gives care to most of gynecologic patients in the city &other parts of the country. All women who had myomectomy at St. Paul’s Hospital Millennium Medical College from September, 2012 to September, 2017 who are eligible were included under the study. 2.2 Sample size determination and sampling technique All women who had abdominal myomectomy from September, 2012 to September, 2017 were included 2.3 Inclusion & Exclusion criteria Inclusion criteria: Women aged from 15 to 40 years of age at the time of surgery, those who had abdominal myomectomy from September 2012 to September 2017 and who are volunteer to give information on phone interview Exclusion criteria : Women with other significant infertility factor (i.e. tubal factor, abnormal SA of partner),those who are not wishing to conceive after myomectomy, Those who had bilateral tubal ligation (BTL), Those who have no phone number on patient medical record, Those who are not responding to phone call, Un matching identity between medical record name and phone responder 2.3 Data collection The patient identification number of all cases of women who had abdominal myomectomy was taken from the hospital register of patient admission, operation room log book and discharge log book from department of OBGYN. Their case files were retrieved from the medical record department of the hospital. A structured questionnaire written in English and customized for this study was used for data collection from each patient chart. The questionnaire includes sociodemographic, indication of myomectomy, intraoperative findings and surgical techniques. Additionally, phone call was made to each patient for additional data that is not recorded in patient chart. Data collectors or interviewers were three trained OBGYN residents. The data collectors were trained for one day about the objectives of the study, techniques of collection, and how to fill the questionnaire. Every day, all of the collected data was reviewed and checked for completeness and relevance by the principal investigator. The collected data was cleaned and entered before analysis. The participants were informed that confidentiality of the information collected and the test result was insured 2.4 data analysis Data were checked for completeness and entered into Epi Info version 7.1 and then exported to SPSS version 23 for further data cleaning and analysis. Frequency distributions were obtained to check for data entry error (missing/unrecognized values and codes). Descriptive statistics, tables, graphs, means, and frequency distribution was used to present the information. The presence of an association between the independent and outcome variable was checked by the Pearson chi-square test. Additionally, each independent variable was fitted separately into bivariate logistic analysis to evaluate for the degree of association with the rate of pregnancy. Also, a further degree of association was assessed by multivariate logistic regression on variables with p-values less than 0.25. The significance level was obtained with 95% CI and p-value < 0.05 to evaluate the degree of association between factors and the rate of pregnancy. Operation definitions Abortion- is the process of pregnancy termination before the gestational age of viability (28 weeks/07months). Spontaneous Abortion- is an abortion without medical or surgical intervention . Abnormal uterine bleeding (AUB) - is defined as menstrual bleeding that is not regular and cyclic and normal. Infertility- is one year unprotected sexual intercourse without conception. Unexplained Infertility- is infertility in which there is no major Causative factor in both partners. Recurrent abortion- refers to two or more consecutive Spontaneous abortions. Results 3.1 Socio demographic characteristics A total of 180 women were included in this study. The mean (±SD) age of the women was 30 (±5.4 SD) and ranged from 20 to 40 years. The age distribution of the participant showed that large proportion 69 (38.3%) belongs to the age group of 26-30. The distribution of the respondent by educational status revealed that 68(37.8%) of women had no formal education. The majority of the mothers were 62 (36.5%) housewives. More than half of the participant 99(55.5%) of the women were urban residents. (Table 1) 3.2 Clinical Characteristics of participants before Myomectomy AUB was the primary indication for myomectomy for 80(44.4%) of women, and for 42(23.3%), pelvic pain was the primary indication for myomectomy. Unexplained infertility was the primary indication for myomectomy for 36(20%) of the women. Half of the women 90(50%) had infertility before surgery. One hundred fourteen (63.3%) of the women were nulligravid whereas 120 (66.7%) of the women were nulliparous. Regarding uterine size before surgery, 161(89.4%) of the participants had ≥12 weeks uterine size. Table 2 3.3 Intra operative finding of the study participants Among females participated in this study, 75(41.7%) of them had 1 to 3 myomas removed. For one hundred forty-seven (81.7%) of them, the largest size of myoma removed was >5cm. Regarding location of the largest myoma removed, 136 (75.9%) of the participants belong to intramural type. In eighty-seven (48.3%) women, myomectomy was done through one incision on uterine wall. For 80(44.4%) of the participants, location of incisions was on both posterior and anterior wall of the uterus. Fifty-six (31.1%) of the participant had endometrial cavity entered while undergoing the surgery. (Table 3) 3.4 Pregnancy rate after myomectomy Out of the 180 female who underwent myomectomy, 94(52.2%) of them became pregnant after myomectomy while 86(47.8%) of them did not get pregnant after myomectomy. Half of the participants were diagnosed with unexplained infertility before the surgery. The pregnancy rate was found to be 56.7% after myomectomy. Of thirty-six patients for whom myomectomy was done for unexplained infertility as a primary indication, 20(55.6%) became pregnant. 3.5 Factors associated with Pregnancy rate after Myomectomy Bivariate analysis was performed and taking p-value <0.25 as a cut of point for determining significance then multivariate analysis was conduct for those with p value < 0. 25. The seven covariates that were significantly associated (p-value<0.25) with fertility after myomectomy at the bivariate analysis were fitted into the backward stepwise multi variable logistic regression model to control for confounding. The final predictors of pregnancy rate after myomectomy were age, infertility before surgery, and number of incision (p-value 35 years were 0.31 times less likely to get pregnant after surgery than those aged 20-25 years [AOR=0.31(95%CI: 0.29-0.54)]. Infertility before surgery was the other predictor. People with no infertility before surgery were 1.19 times more likely to be pregnant after surgery than those with unexplained infertility before the surgery [AOR=1.19(95%CI: 1.06-1.57)]. Number of incision was also statistically significant in that people with two incisions were 0.06 times less likely while those with ≥3 incisions were 0.02 times less likely to get pregnant than those with one incision on the uterine wall [AOR=0.06(95%CI:0.05-0.51)] and [AOR=0.02(95%CI: 0.002-0.22)] respectively.(Table 5) Discussion This is a health facility based retrospective cross-sectional study aimed to assess the magnitude of pregnancy rate after myomectomy and associated factor(s) among women who underwent abdominal myomectomy surgery in SPHMMC from September, 2012 to September, 2017. The finding revealed that magnitude of fertility after myomectomy was significantly associated with age, number of incisions, location of incision and infertility before surgery. Among female participated in this study 52.2% of the females got pregnant after myomectomy. This is almost similar to a study done in china which found that 50.3% of women after myomectomy were able to conceive( 13 ). The result of this study was higher than a study done in Hungary which stated that 40.4% of women got pregnant after myomectomy( 14 ). On the other hand our study finding was lower than a study done in UK which found that 57% pregnancy rate after myomectomy( 3 ); the finding from USA found the same result as UK finding which 57% pregnancy rate was after surgery( 15 ). Similar study done in New York also found 65.2% of pregnancy rate ( 16 ). This study found that age was significantly associated with pregnancy rate after myomectomy. Participants aged > 35 years were less likely to be pregnant than those age group 20–25 years. In a study done at Jessop Hospital, UK, women aged ≤ 35 had a significantly higher chance of conception (74%) than women ≥ 36years (30%)( 3 ).Other study done in China also found that younger people have a higher pregnancy rate than older( 13 ). A study done in Senegal also support the result of this study, younger people get pregnant than those older people after myomectomy( 17 ). Number of incisions was also significantly associated with pregnancy rate after myomectomy. Participants who had both two, and three and more than three incisions were less likely to get pregnant after myomectomy than those with only one incision. This can be explained by that as the number of incision increases, the risk of adhesion possibly blocking fallopian tubes also increases.(3, 7, 8) Infertility before surgery was also significantly associated with pregnancy rate after myomectomy. Participants who had a known infertility were less likely to get pregnant after myomectomy than those who did not complain failure to conceive before surgery. Infertility before myomectomy is a factor of poor prognosis for the subsequent pregnancy(17). Myomectomy improved pregnancy rate by 55.7% in patients with unexplained infertility. This figure is higher than the study done at Johns Hopkins University of school of medicine (51%) and lower than the on done at North shore University Hospital (65.2%) (15, 16) Conclusion Over all, half of the participants were able to get pregnant after myomectomy. Age, number of incision, infertility before surgery and location of incision were significantly associated with rate of pregnancy after myomectomy. Myomectomy improved pregnancy rate in those who had unexplained infertility before the index surgery List Of Abbreviations AFS ………………... American Fertility Society BS ………………… Bilateral salpingectomy BTL ………………. Bilateral tubal ligation HSG ………………... Hysterosalpingography IUA ………………… Intrauterine adhesion OBGYN ……………. Obstetrics & Gynecology RPL ………………... Recurrent pregnancy loss TAH ………………… Tikur Anbessa Hospital SA …………………... Semen analysis SPHMMC…………. Saint Paul’s Hospital Millennium Medical College Declarations Acknowledgments To obstetrics and gynecology department of Saint Paul’s Millennium Medical College Competing interests No competing interest Ethical clearance Ethical clearance is obtained from SPMMC Consent Not applicable Funding SPMMC and it has no interest Authors contributions Dr. meseret olana: proposal development, data collection, data analysis Dr. temesgen tantu, Dr. tadios mekonen and Mr. muluken gunta: data collection, data analysis, manuscript preparation Availability of data Any needed data will be shared whenever asked. References Berek JS, PJA H. Berek & Novak, s gynecology 15th ed. Tehran: Artin teb. 2012. Kasum M. Fertility following myomectomy. Acta Clin Croat. 2009;48(2):137-43. Li T, Mortimer R, Cooke I. Myomectomy: a retrospective study to examine reproductive performance before and after surgery. Human reproduction. 1999;14(7):1735-40. Garcia C-R, Tureck RW. Submucosal leiomyomas and infertility. Fertility and sterility. 1984;42(1):16-9. Vercellini P, Maddalena S, De Giorgi O, Pesole A, Ferrari L, Crosignani PG. Determinants of reproductive outcome after abdominal myomectomy for infertility. Fertility and sterility. 1999;72(1):109-14. Seinera P, Farina C, Todros T. Laparoscopic myomectomy and subsequent pregnancy: results in 54 patients. Human reproduction. 2000;15(9):1993-6. Chigbu B, Onwere S, Aluka C, Kamanu C, Feyi-Waboso P, Okoro O, et al. Fertility following myomectomy at Aba, Southeastern Nigeria. Journal of Medical Investigations and Practice. 2014;9(4):136. Dahlman M, Palmer M, Havstad S, Wegienka G, Eisenstein D, Bagaria M, et al. Fertility after Myomectomy: A Retrospective Cohort Study. Journal of Minimally Invasive Gynecology. 2012;19(6):S48-S9. Frederick J, Hardie M, Reid M, Fletcher H, Wynter S, Frederick C. Operative morbidity and reproductive outcome in secondary myomectomy: a prospective cohort study. Human Reproduction. 2002;17(11):2967-71. Carls GS, Lee DW, Ozminkowski RJ, Wang S, Gibson TB, Stewart E. What are the total costs of surgical treatment for uterine fibroids? Journal of women's health. 2008;17(7):1119-32. Gaym A. Leiomyoma uteri in Ethiopian women: a clinical study. Ethiopian medical journal. 2004;42(3):199-204. Guo XC, Segars JH. The impact and management of fibroids for fertility: an evidence-based approach. Obstetrics and Gynecology Clinics. 2012;39(4):521-33. Zhang Y, Hua KQ. Patients' age, myoma size, myoma location, and interval between myomectomy and pregnancy may influence the pregnancy rate and live birth rate after myomectomy. Journal of Laparoendoscopic & Advanced Surgical Techniques. 2014;24(2):95-9. Gavai M, Berkes E, Lazar L, Fekete T, Takacs ZF, Urbancsek J, et al. Factors affecting reproductive outcome following abdominal myomectomy. Journal of assisted reproduction and genetics. 2007;24(11):525-31. Gehlbach D, Sousa R, Carpenter S, Rock J. Abdominal myomectomy in the treatment of infertility. International Journal of Gynecology & Obstetrics. 1993;40(1):45-50. Rosenfeld DL. Abdominal myomectomy for otherwise unexplained infertility. Fertility and sterility. 1986;46(2):328-30. Dieme MEF, Niang MM, Gassama O, Diouf AA, Coulibaly MT, Diouf A, et al. Practice of diagnostic hysteroscopy after myomectomy in the prevention of intrauterine adhesions: experience of Ouakam military hospital (Dakar, Senegal). International Journal of Reproduction, Contraception, Obstetrics and Gynecology.7(5):1694. Tables Table 1 Intra operative finding of women who underwent myomectomy, SPHMMC, Addis Ababa, 2019 Variable Frequency Percentage Number of myomas removed 1–3 75 41.7 4–5 39 21.7 > 5 60 33.3 Unspecified 6 3.3 Size of the largest myoma removed (cm) ≤ 5 21 11.7 > 5 147 81.7 Unspecified 12 6.7 Location of the largest myoma removed Submucous 24 13.4 Intramural 136 75.9 Subserous 13 7.3 Unspecified 6 3.4 Number of incision 1 87 48.3 2 53 29.4 ≥ 3 16 8.9 Unspecified 24 13.3 Location of incision(s) on the uterus anterior wall 67 37.2 posterior wall 21 11.6 both anterior & posterior wall 80 44.4 Unspecified 12 6.7 Endometrial cavity entered Yes 56 31.1 No 124 68.9 Table 2 Bivariate and Multivariate Logistic Regression Analysis of Factors associated with Fertility after Myomectomy, SPHMMC, Addis Ababa, 2019 Variable Fertility after myomectomy COR (95%CI) AOR (95%CI) Yes n(%) No n(%) Age 20–25 13(39.4) 20(60.6) 1 26–30 40(57.9) 29(42.0) 0.47(0.20–1.09) 0.81(0.27–2.46) 31–35 27(55.1) 22(44.9) 0.52(0.21–1.29) 1.29(0.35–4.69) > 35 14(48.3) 15(51.7) 0.69(0.25–1.91) 0.31(0.29–0.54)* Primary indication for myomectomy AUB 42(52.5) 38(47.5) 1 Recurrent abortion 4(80.0) 1(20.0) 0.28(0.03–2.58) 0.21(0.01–4.23) Unexplained infertility 20(55.6) 16(44.4) 0.88(0.40–1.94) 1.67(0.50–5.48) Pelvic pain 22(52.4) 20(47.6) 1.01(0.47–2.12) 1.25(0.45–3.46) Other 6(35.3) 11(64.7) 2.02(0.68–6.01) 1.65(0.35–7.69) Infertility before surgery Yes 51(56.7) 39(43.3) 0.41(0.19–0.86) 0.30(0.10–0.89) No 28(59.6) 19(40.4) 1.36(0.15–0.85) 1.19(1.06–1.57)* Unknown 15(34.9) 28(65.1) 1 Uterine size before surgery 5 33(55.0) 27(45.0) 0.75(0.38–1.49) 1.34(0.47–3.79) Unspecified - 4(100.0) - - No. of incision 1 37(42.5) 50(57.5) 1 2 33(62.3) 20(37.7) 0.45(0.22–0.90) 0.06(0.05–0.51)* ≥ 3 11(68.8) 5(31.3) 0.33(0.10–1.05) 0.02(0.002–0.22)* Unspecified 13(54.2) 11(45.8) 0.62(0.25–1.55) 0.08(0.01–0.62) Location of incision on the uterus anterior wall 33(49.3) 34(50.7) 1 posterior wall 8(38.1) 13(61.9) 1.58(0.58–4.29) 2.70(0.73–9.95) Both anterior & posterior wall 48(60.0) 32(40.0) 1.64(0.33–1.94) 3.09(0.98–51.04) unspecified 5(41.7) 7(58.3) 1.35(0.39–4.71) 5.69(0.57–11.64) *p value < 0.05 Tables 3-5 are not available with this version. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-250064","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research","associatedPublications":[],"authors":[{"id":14070087,"identity":"12af5bf5-f8fb-451f-8030-accc7736c919","order_by":0,"name":"meseret olana jeldu","email":"","orcid":"","institution":"Wolkite University","correspondingAuthor":false,"prefix":"","firstName":"meseret","middleName":"olana","lastName":"jeldu","suffix":""},{"id":14070088,"identity":"9ee62cd5-91a6-40fc-aa94-63b97c7db107","order_by":1,"name":"Tadios Mekonnen asress","email":"","orcid":"","institution":"St Paul's Hospital Millennium Medical College","correspondingAuthor":false,"prefix":"","firstName":"Tadios","middleName":"Mekonnen","lastName":"asress","suffix":""},{"id":14070089,"identity":"c12f6001-f002-47b2-9657-f9791fd31be4","order_by":2,"name":"temesgen tantu arusi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA90lEQVRIiWNgGAWjYHCDg+0fPgApNnYC6nhAxAEGBgkGxsPHGGeAtDATrYX5WBozmEdIiz17d+LnDzV36gyOnTF7bPNrmzwfMwPjh485eGzhObtZ4sCxZxIGZ86YG+f23TZsY2Zglpy5DY8WidwNEgfYDksY3DhjIJ3bc5sRqIWNmRefFvm3m38c+AfUcv+NgbRlz217wlokeLdJHGwDajlwLE2a4cftRMJazuRuszjbd1hy5oHDhw17G24ntzEzNuP1C3v72c03Kr4d5uc7cLDxwY8/t23ntzcf/PARjxZUwNgGJhuIVQ8Cf0hRPApGwSgYBSMFAAC6wFlXvuJGYgAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0002-6808-9166","institution":"wolkite university","correspondingAuthor":true,"prefix":"","firstName":"temesgen","middleName":"tantu","lastName":"arusi","suffix":""},{"id":14070090,"identity":"5410a3d4-df3c-4fde-8052-917ccceb342b","order_by":3,"name":"Muluken Gunta gutulo","email":"","orcid":"","institution":"CDC director at wolaita zone","correspondingAuthor":false,"prefix":"","firstName":"Muluken","middleName":"Gunta","lastName":"gutulo","suffix":""}],"badges":[],"createdAt":"2021-02-17 04:54:29","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-250064/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-250064/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1155/2021/6680112","type":"published","date":"2021-11-28T21:54:17+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":6519532,"identity":"9df6f397-bca2-4c8a-803b-370a8f9262aa","added_by":"auto","created_at":"2021-03-02 15:01:05","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":40670,"visible":true,"origin":"","legend":"Pregnancy rate after myomectomy","description":"","filename":"Fig1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-250064/v1/c3273fdaab50e118377d64cd.jpg"},{"id":15949509,"identity":"b7bbde2f-8ddc-4063-b498-9f8e8a04be05","added_by":"auto","created_at":"2021-11-28 21:54:24","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":526013,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-250064/v1/ea40acc9-3e5b-41e4-924d-c034e9ec4dd9.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003ePregnancy Rate After Myomectomy and Associated Factors Among Reproductive Age Women Who Had Myomectomy at Saint Paul’s Hospital Millennium Medical College, Addis Ababa: Retrospective Cross-sectional Study.\u003c/p\u003e","fulltext":[{"header":"Plain English","content":"\u003cp\u003eMyoma is one of the commonest abnormal uterine enlargement occurs in reproductive age women. It is commonly associated with infertility but literatures in 2\u0026ndash;3% of cases associate mere presence of myoma as cause of infertility. The aim of this study is to assess the rate of pregnancy after myomectomy for women having myoma and its associated factors.\u003c/p\u003e\n\u003cp\u003eThe retrospective study was done to retrieve 180 women cards for whom myomectomy done in saint poul\u0026rsquo;s millennium medical college from September, 2012 to September, 2017. In addition to card retrieval, phone interviews done with selected women. From cards of individuals history as well as surgical techniques selected like number of uterine incisions, location of myoma and incisions, indications for surgery, previous history of infertility and other parameters taken to determine the rate of pregnancy.\u003c/p\u003e\n\u003cp\u003eHundred eighty women participated in the study and 52.2% got pregnant.\u0026nbsp;Moreover, the younger the age the higher the chance of getting pregnancy. Previous history of infertility before myomectomy and number of uterine incisions have influence on the rate of pregnancy.\u003c/p\u003e\n\u003cp\u003eFinally, the study showed that the age, number of uterine incisions and previous history of infertility are conditions which have influence on the rate of pregnancy after myomectomy\u003c/p\u003e"},{"header":"Introduction","content":"\u003cp\u003eUterine myoma is a monoclonal, benign tumor arising from smooth muscles of the uterus. It occurs in 20\u0026ndash;50% of reproductive age women and can be identified by ultrasound in approximately 80% of African-American and 70% of white American women by the time they reach menopause(\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e). These tumors are classified based on their location and direction of growth: submucous, Intramural \u0026amp; subserous. Submucous myomas are proximate to the endometrium and grow toward and bulge into the endometrial cavity (\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e4\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e6\u003c/span\u003e).\u003c/p\u003e\n\u003cp\u003eThe role of myomas as a causative factor in infertility remains controversial. It has been proposed that myomas interfere sperm transport, cause cervical and/or tubal blockage, distort endometrial cavity, or may cause inflammation to endometrium or secretion of vasoactive substances (\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e). According to AFS guideline for practice, myomas may be associated with 5 to 10% of infertility but it is sole factor in only 2 to3% of all infertility cases. Even though myomectomy is the recommended treatment for symptomatic myomas among women wishing to preserve their fertility, the fertility performance of the women after this surgery is not thoroughly studied \u0026amp; detailed. It may also be associated with infertility due to extensive adhesion causing tubal blockage and intrauterine adhesions (IUAs) if endometrium is breached during surgery(\u003cspan class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e).\u003c/p\u003e\n\u003cp\u003eMyomectomy is found to significantly increase conception rate in women with myomas as a sole factor of infertility. The conception rate following myomectomy ranged from 25 to 77% in available retrospective studies(\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e). In different retrospective study done at different hospitals and country showed improvement in fertility after myomectomy. Moreover, Age of the women, presence of pelvic adhesion and the presence of concomitant history of unexplained infertility have negative influence on chance of conception after myomectomy. There was no significant difference in pregnancy rate according to whether the uterine cavity is entered or not, preoperative size, location and size of myoma(s)(\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e7\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e9\u003c/span\u003e).\u003c/p\u003e\n\u003cp\u003eMany of the women with symptomatic myoma are in reproductive age group and need for future fertility (\u003cspan class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e7\u003c/span\u003e, \u003cspan class=\"CitationRef\"\u003e10\u003c/span\u003e\u0026ndash;\u003cspan class=\"CitationRef\"\u003e12\u003c/span\u003e). There is shortage of data done in this area of interest as well as there is no research done on fertility performance after myomectomy in Ethiopia. For this reason and due to uncertainty of effect of myomectomy on pregnancy rate, physicians always face dilemma in counseling and management options of women with symptomatic myomas who need to conserve their fertility.\u003c/p\u003e"},{"header":"Materials And Methods","content":"\u003cp\u003e\u003cstrong\u003e2.1 study area, design, and populations.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eInstitution based cross sectional study was undertaken at St. Paul\u0026rsquo;s Hospital Millennium Medical College, in Addis Ababa, the capital city of Ethiopia from November 1, 2018 to December 30, 2018. It is the hospital with highest delivery rate and gives care to most of gynecologic patients in the city \u0026amp;other parts of the country. All women who had myomectomy at St. Paul\u0026rsquo;s Hospital Millennium Medical College from September, 2012 to September, 2017 who are eligible were included under the study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.2 Sample size determination and sampling technique\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll women who had abdominal myomectomy from September, 2012 to September, 2017 were included\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.3 Inclusion \u0026amp; Exclusion criteria\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eInclusion criteria:\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWomen aged from 15 to 40 years of age at the time of surgery, those who had abdominal myomectomy from September 2012 to September 2017 and who are volunteer to give information on phone interview\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eExclusion criteria\u003c/strong\u003e:\u003c/p\u003e\n\u003cp\u003eWomen with other significant infertility factor (i.e. tubal factor, abnormal SA of partner),those who are not wishing to conceive after myomectomy, Those who had bilateral tubal ligation (BTL), Those who have no phone number on patient medical record, Those who are not responding to phone call, Un matching identity between medical record name and phone responder\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.3 Data collection\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe patient identification number of all cases of women who had abdominal myomectomy was taken from the hospital register of patient admission, operation room log book and discharge log book from department of OBGYN. Their case files were retrieved from the medical record department of the hospital. A structured questionnaire written in English and customized for this study was used for data collection from each patient chart. The questionnaire includes sociodemographic, indication of myomectomy, intraoperative findings and surgical techniques. Additionally, phone call was made to each patient for additional data that is not recorded in patient chart. Data collectors or interviewers were three trained OBGYN residents. The data collectors were trained for one day about the objectives of the study, techniques of collection, and how to fill the questionnaire. Every day, all of the collected data was reviewed and checked for completeness and relevance by the principal investigator. The collected data was cleaned and entered before analysis. The participants were informed that confidentiality of the information collected and the test result was insured\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2.4 data analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eData were checked for completeness and entered into Epi Info version 7.1 and then exported to SPSS version 23 for further data cleaning and analysis. Frequency distributions were obtained to check for data entry error (missing/unrecognized values and codes). Descriptive statistics, tables, graphs, means, and frequency distribution was used to present the information. The presence of an association between the independent and outcome variable was checked by the Pearson chi-square test. Additionally, each independent variable was fitted separately into bivariate logistic analysis to evaluate for the degree of association with the rate of pregnancy. Also, a further degree of association was assessed by multivariate logistic regression on variables with p-values less than 0.25. The significance level was obtained with 95% CI and p-value \u0026lt; 0.05 to evaluate the degree of association between factors and the rate of pregnancy.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eOperation definitions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAbortion- is the process of pregnancy termination before the gestational age of viability (28 weeks/07months).\u003c/p\u003e\n\u003cp\u003eSpontaneous Abortion- is an abortion without medical or surgical intervention .\u003c/p\u003e\n\u003cp\u003eAbnormal uterine bleeding (AUB) - is defined as menstrual bleeding that is not regular and cyclic and normal.\u003c/p\u003e\n\u003cp\u003eInfertility- is one year unprotected sexual intercourse without conception.\u003c/p\u003e\n\u003cp\u003eUnexplained Infertility- is infertility in which there is no major Causative factor in both partners.\u003c/p\u003e\n\u003cp\u003eRecurrent abortion- refers to two or more consecutive Spontaneous abortions.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003e3.1 Socio demographic characteristics\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA total of 180 women were included in this study. The mean (\u0026plusmn;SD) age of the women was 30 (\u0026plusmn;5.4 SD) and ranged from 20 to 40 years. The age distribution of the participant showed that large proportion 69 (38.3%) belongs to the age group of 26-30. The distribution of the respondent by educational status revealed that 68(37.8%) of women had no formal education. The majority of the mothers were 62 (36.5%) housewives. More than half of the participant 99(55.5%) of the women were urban residents. (Table 1)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e3.2 Clinical Characteristics of participants before Myomectomy\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAUB was the primary indication for myomectomy for 80(44.4%) of women, and for 42(23.3%), pelvic pain was the primary indication for myomectomy. Unexplained infertility was the primary indication for myomectomy for 36(20%) of the women. Half of the women 90(50%) had infertility before surgery. One hundred fourteen (63.3%) of the women were nulligravid whereas 120 (66.7%) of the women were nulliparous. Regarding uterine size before surgery, 161(89.4%) of the participants had \u0026ge;12 weeks uterine size. Table 2\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e3.3 Intra operative finding of the study participants\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAmong females participated in this study, 75(41.7%) of them had 1 to 3 myomas removed. For one hundred forty-seven (81.7%) of them, the largest size of myoma removed was \u0026gt;5cm. Regarding location of the largest myoma removed, 136 (75.9%) of the participants belong to intramural type. In eighty-seven (48.3%) women, myomectomy was done through one incision on uterine wall. For 80(44.4%) of the participants, location of incisions was on both posterior and anterior wall of the uterus. Fifty-six (31.1%) of the participant had endometrial cavity entered while undergoing the surgery. (Table 3)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e3.4 Pregnancy rate after myomectomy\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eOut of the 180 female who underwent myomectomy, 94(52.2%) of them became pregnant after myomectomy while 86(47.8%) of them did not get pregnant after myomectomy. Half of the participants were diagnosed with unexplained infertility before the surgery. The pregnancy rate was found to be 56.7% after myomectomy. Of thirty-six patients for whom myomectomy was done for unexplained infertility as a primary indication, 20(55.6%) became pregnant.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e3.5 Factors associated with Pregnancy rate after Myomectomy\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBivariate analysis was performed and taking p-value \u0026lt;0.25 as a cut of point for determining significance then multivariate analysis was conduct for those with p value \u0026lt; 0. 25. The seven covariates that were significantly associated (p-value\u0026lt;0.25) with fertility after myomectomy at the bivariate analysis were fitted into the backward stepwise multi variable logistic regression model to control for confounding. The final predictors of pregnancy rate after myomectomy were age, infertility before surgery, and number of incision (p-value \u0026lt;0.05). Age was significantly associated with pregnancy rate after myomectomy. Participants aged \u0026gt;35 years were 0.31 times less likely to get pregnant after surgery than those aged 20-25 years [AOR=0.31(95%CI: 0.29-0.54)]. Infertility before surgery was the other predictor. People with no infertility before surgery were 1.19 times more likely to be pregnant after surgery than those with unexplained infertility before the surgery [AOR=1.19(95%CI: 1.06-1.57)]. Number of incision was also statistically significant in that people with two incisions were 0.06 times less likely while those with \u0026ge;3 incisions were 0.02 times less likely to get pregnant than those with one incision on the uterine wall [AOR=0.06(95%CI:0.05-0.51)] and [AOR=0.02(95%CI: 0.002-0.22)] respectively.(Table 5)\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThis is a health facility based retrospective cross-sectional study aimed to assess the magnitude of pregnancy rate after myomectomy and associated factor(s) among women who underwent abdominal myomectomy surgery in SPHMMC from September, 2012 to September, 2017. The finding revealed that magnitude of fertility after myomectomy was significantly associated with age, number of incisions, location of incision and infertility before surgery.\u003c/p\u003e\n\u003cp\u003eAmong female participated in this study 52.2% of the females got pregnant after myomectomy. This is almost similar to a study done in china which found that 50.3% of women after myomectomy were able to conceive(\u003cspan class=\"CitationRef\"\u003e13\u003c/span\u003e). The result of this study was higher than a study done in Hungary which stated that 40.4% of women got pregnant after myomectomy(\u003cspan class=\"CitationRef\"\u003e14\u003c/span\u003e). On the other hand our study finding was lower than a study done in UK which found that 57% pregnancy rate after myomectomy(\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e); the finding from USA found the same result as UK finding which 57% pregnancy rate was after surgery(\u003cspan class=\"CitationRef\"\u003e15\u003c/span\u003e). Similar study done in New York also found 65.2% of pregnancy rate (\u003cspan class=\"CitationRef\"\u003e16\u003c/span\u003e).\u003c/p\u003e\n\u003cp\u003eThis study found that age was significantly associated with pregnancy rate after myomectomy. Participants aged\u0026thinsp;\u0026gt;\u0026thinsp;35 years were less likely to be pregnant than those age group 20\u0026ndash;25 years. In a study done at Jessop Hospital, UK, women aged\u0026thinsp;\u0026le;\u0026thinsp;35 had a significantly higher chance of conception (74%) than women\u0026thinsp;\u0026ge;\u0026thinsp;36years (30%)(\u003cspan class=\"CitationRef\"\u003e3\u003c/span\u003e).Other study done in China also found that younger people have a higher pregnancy rate than older(\u003cspan class=\"CitationRef\"\u003e13\u003c/span\u003e). A study done in Senegal also support the result of this study, younger people get pregnant than those older people after myomectomy(\u003cspan class=\"CitationRef\"\u003e17\u003c/span\u003e).\u003c/p\u003e\n\u003cp\u003eNumber of incisions was also significantly associated with pregnancy rate after myomectomy. Participants who had both two, and three and more than three incisions were less likely to get pregnant after myomectomy than those with only one incision. This can be explained by that as the number of incision increases, the risk of adhesion possibly blocking fallopian tubes also increases.(3, 7, 8)\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eInfertility before surgery was also significantly associated with pregnancy rate after myomectomy. Participants who had a known infertility were less likely to get pregnant after myomectomy than those who did not complain failure to conceive before surgery. Infertility before myomectomy is a factor of poor prognosis for the subsequent pregnancy(17).\u003c/p\u003e\n\u003cp\u003eMyomectomy improved pregnancy rate by 55.7% in patients with unexplained infertility. This figure is higher than the study done at Johns Hopkins University of school of medicine (51%) and lower than the on done at North shore University Hospital (65.2%) (15, 16)\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eOver all, half of the participants were able to get pregnant after myomectomy. Age, number of incision, infertility before surgery and location of incision were significantly associated with rate of pregnancy after myomectomy. Myomectomy improved pregnancy rate in those who had unexplained infertility before the index surgery\u003c/p\u003e"},{"header":"List Of Abbreviations","content":"\u003cp\u003eAFS \u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;... American Fertility Society\u003c/p\u003e\n\u003cp\u003eBS \u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip; Bilateral salpingectomy\u003c/p\u003e\n\u003cp\u003eBTL \u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;. Bilateral tubal ligation\u003c/p\u003e\n\u003cp\u003eHSG \u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;... Hysterosalpingography\u003c/p\u003e\n\u003cp\u003eIUA \u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip; Intrauterine adhesion\u003c/p\u003e\n\u003cp\u003eOBGYN \u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;. Obstetrics \u0026amp; Gynecology\u003c/p\u003e\n\u003cp\u003eRPL \u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;... Recurrent pregnancy loss\u003c/p\u003e\n\u003cp\u003eTAH \u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip; Tikur Anbessa Hospital\u003c/p\u003e\n\u003cp\u003eSA \u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;... Semen analysis\u003c/p\u003e\n\u003cp\u003eSPHMMC\u0026hellip;\u0026hellip;\u0026hellip;\u0026hellip;. Saint Paul\u0026rsquo;s Hospital Millennium Medical College\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgments\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo obstetrics and gynecology department of Saint Paul\u0026rsquo;s Millennium Medical College\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo competing interest\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthical clearance \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eEthical clearance is obtained from SPMMC\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSPMMC and it has no interest\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDr. meseret olana: proposal development, data collection, data analysis\u003c/p\u003e\n\u003cp\u003eDr. temesgen tantu, Dr. tadios mekonen and Mr. muluken gunta: data collection, data analysis, manuscript preparation\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAny needed data will be shared whenever asked.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eBerek JS, PJA H. Berek \u0026amp; Novak, s gynecology 15th ed. Tehran: Artin teb. 2012.\u003c/li\u003e\n\u003cli\u003eKasum M. Fertility following myomectomy. Acta Clin Croat. 2009;48(2):137-43.\u003c/li\u003e\n\u003cli\u003eLi T, Mortimer R, Cooke I. Myomectomy: a retrospective study to examine reproductive performance before and after surgery. Human reproduction. 1999;14(7):1735-40.\u003c/li\u003e\n\u003cli\u003eGarcia C-R, Tureck RW. Submucosal leiomyomas and infertility. Fertility and sterility. 1984;42(1):16-9.\u003c/li\u003e\n\u003cli\u003eVercellini P, Maddalena S, De Giorgi O, Pesole A, Ferrari L, Crosignani PG. Determinants of reproductive outcome after abdominal myomectomy for infertility. Fertility and sterility. 1999;72(1):109-14.\u003c/li\u003e\n\u003cli\u003eSeinera P, Farina C, Todros T. Laparoscopic myomectomy and subsequent pregnancy: results in 54 patients. Human reproduction. 2000;15(9):1993-6.\u003c/li\u003e\n\u003cli\u003eChigbu B, Onwere S, Aluka C, Kamanu C, Feyi-Waboso P, Okoro O, et al. Fertility following myomectomy at Aba, Southeastern Nigeria. Journal of Medical Investigations and Practice. 2014;9(4):136.\u003c/li\u003e\n\u003cli\u003eDahlman M, Palmer M, Havstad S, Wegienka G, Eisenstein D, Bagaria M, et al. Fertility after Myomectomy: A Retrospective Cohort Study. Journal of Minimally Invasive Gynecology. 2012;19(6):S48-S9.\u003c/li\u003e\n\u003cli\u003eFrederick J, Hardie M, Reid M, Fletcher H, Wynter S, Frederick C. Operative morbidity and reproductive outcome in secondary myomectomy: a prospective cohort study. Human Reproduction. 2002;17(11):2967-71.\u003c/li\u003e\n\u003cli\u003eCarls GS, Lee DW, Ozminkowski RJ, Wang S, Gibson TB, Stewart E. What are the total costs of surgical treatment for uterine fibroids? Journal of women's health. 2008;17(7):1119-32.\u003c/li\u003e\n\u003cli\u003eGaym A. Leiomyoma uteri in Ethiopian women: a clinical study. Ethiopian medical journal. 2004;42(3):199-204.\u003c/li\u003e\n\u003cli\u003eGuo XC, Segars JH. The impact and management of fibroids for fertility: an evidence-based approach. Obstetrics and Gynecology Clinics. 2012;39(4):521-33.\u003c/li\u003e\n\u003cli\u003eZhang Y, Hua KQ. Patients' age, myoma size, myoma location, and interval between myomectomy and pregnancy may influence the pregnancy rate and live birth rate after myomectomy. Journal of Laparoendoscopic \u0026amp; Advanced Surgical Techniques. 2014;24(2):95-9.\u003c/li\u003e\n\u003cli\u003eGavai M, Berkes E, Lazar L, Fekete T, Takacs ZF, Urbancsek J, et al. Factors affecting reproductive outcome following abdominal myomectomy. Journal of assisted reproduction and genetics. 2007;24(11):525-31.\u003c/li\u003e\n\u003cli\u003eGehlbach D, Sousa R, Carpenter S, Rock J. Abdominal myomectomy in the treatment of infertility. International Journal of Gynecology \u0026amp; Obstetrics. 1993;40(1):45-50.\u003c/li\u003e\n\u003cli\u003eRosenfeld DL. Abdominal myomectomy for otherwise unexplained infertility. Fertility and sterility. 1986;46(2):328-30.\u003c/li\u003e\n\u003cli\u003eDieme MEF, Niang MM, Gassama O, Diouf AA, Coulibaly MT, Diouf A, et al. Practice of diagnostic hysteroscopy after myomectomy in the prevention of intrauterine adhesions: experience of Ouakam military hospital (Dakar, Senegal). International Journal of Reproduction, Contraception, Obstetrics and Gynecology.7(5):1694.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cdiv class=\"gridtable\"\u003e\n\u003ctable id=\"Tab2\" border=\"1\"\u003e\u003ccaption\u003e\n\u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e\n\u003cdiv class=\"CaptionContent\"\u003e\n\u003cp\u003eIntra operative finding of women who underwent myomectomy, SPHMMC, Addis Ababa, 2019\u003c/p\u003e\n\u003c/div\u003e\n\u003c/caption\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eVariable\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\u0026nbsp;\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003eFrequency\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003ePercentage\u003c/p\u003e\n\u003c/th\u003e\n\u003c/tr\u003e\n\u003c/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNumber of myomas removed\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u0026ndash;3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e75\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e41.7\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u0026ndash;5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e39\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e21.7\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u0026gt;\u0026thinsp;5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e60\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e33.3\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eUnspecified\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e3.3\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eSize of the largest myoma removed (cm)\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u0026le;\u0026thinsp;5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e11.7\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u0026gt;\u0026thinsp;5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e147\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e81.7\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eUnspecified\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e6.7\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eLocation of the largest myoma removed\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eSubmucous\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e13.4\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eIntramural\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e136\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e75.9\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eSubserous\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e13\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e7.3\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eUnspecified\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e6\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e3.4\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNumber of incision\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e87\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e48.3\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e53\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e29.4\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u0026ge;\u0026thinsp;3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e16\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e8.9\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eUnspecified\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e24\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e13.3\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eLocation of incision(s) on the uterus\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eanterior wall\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e67\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e37.2\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eposterior wall\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e21\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e11.6\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eboth anterior \u0026amp; posterior wall\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e80\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e44.4\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eUnspecified\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e6.7\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eEndometrial cavity entered\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eYes\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e56\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e31.1\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNo\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e124\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e68.9\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cdiv class=\"gridtable\"\u003e\n\u003ctable id=\"Tab1\" border=\"1\"\u003e\u003ccaption\u003e\n\u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e\n\u003cdiv class=\"CaptionContent\"\u003e\n\u003cp\u003eBivariate and Multivariate Logistic Regression Analysis of Factors associated with Fertility after Myomectomy, SPHMMC, Addis Ababa, 2019\u003c/p\u003e\n\u003c/div\u003e\n\u003c/caption\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eVariable\u003c/p\u003e\n\u003c/th\u003e\n\u003cth colspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eFertility after myomectomy\u003c/p\u003e\n\u003c/th\u003e\n\u003cth rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eCOR (95%CI)\u003c/p\u003e\n\u003c/th\u003e\n\u003cth rowspan=\"2\" align=\"left\"\u003e\n\u003cp\u003eAOR (95%CI)\u003c/p\u003e\n\u003c/th\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eYes\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003en(%)\u003c/strong\u003e\u003c/p\u003e\n\u003c/th\u003e\n\u003cth align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNo\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003en(%)\u003c/strong\u003e\u003c/p\u003e\n\u003c/th\u003e\n\u003c/tr\u003e\n\u003c/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eAge\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e20\u0026ndash;25\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e13(39.4)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e20(60.6)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e26\u0026ndash;30\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e40(57.9)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e29(42.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.47(0.20\u0026ndash;1.09)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.81(0.27\u0026ndash;2.46)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e31\u0026ndash;35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e27(55.1)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e22(44.9)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.52(0.21\u0026ndash;1.29)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.29(0.35\u0026ndash;4.69)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u0026gt;\u0026thinsp;35\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e14(48.3)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e15(51.7)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.69(0.25\u0026ndash;1.91)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.31(0.29\u0026ndash;0.54)*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003ePrimary indication for myomectomy\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eAUB\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e42(52.5)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e38(47.5)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eRecurrent abortion\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4(80.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e1(20.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.28(0.03\u0026ndash;2.58)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.21(0.01\u0026ndash;4.23)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eUnexplained infertility\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e20(55.6)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e16(44.4)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.88(0.40\u0026ndash;1.94)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.67(0.50\u0026ndash;5.48)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003ePelvic pain\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e22(52.4)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e20(47.6)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.01(0.47\u0026ndash;2.12)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.25(0.45\u0026ndash;3.46)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eOther\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e6(35.3)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e11(64.7)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.02(0.68\u0026ndash;6.01)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.65(0.35\u0026ndash;7.69)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eInfertility before surgery\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eYes\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e51(56.7)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e39(43.3)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.41(0.19\u0026ndash;0.86)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.30(0.10\u0026ndash;0.89)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eNo\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e28(59.6)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e19(40.4)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.36(0.15\u0026ndash;0.85)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.19(1.06\u0026ndash;1.57)*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eUnknown\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e15(34.9)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e28(65.1)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eUterine size before surgery\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u0026lt;\u0026thinsp;12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e13(68.4)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e6(31.6)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u0026ge;\u0026thinsp;12\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e81(50.3)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e80(49.7)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.13(0.77\u0026ndash;5.91)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.51(0.48\u0026ndash;4.27)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNo. of myomas removed\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u0026ndash;3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e36(48.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e39(52.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e4\u0026ndash;5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e24(61.5)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e15(38.5)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.57(0.26\u0026ndash;1.27)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.92(0.33\u0026ndash;2.57)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u0026gt;\u0026thinsp;5\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e33(55.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e27(45.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.75(0.38\u0026ndash;1.49)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.34(0.47\u0026ndash;3.79)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eUnspecified\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e4(100.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e-\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eNo. of incision\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e37(42.5)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e50(57.5)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e33(62.3)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e20(37.7)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.45(0.22\u0026ndash;0.90)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.06(0.05\u0026ndash;0.51)*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u0026ge;\u0026thinsp;3\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e11(68.8)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e5(31.3)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.33(0.10\u0026ndash;1.05)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.02(0.002\u0026ndash;0.22)*\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eUnspecified\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e13(54.2)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e11(45.8)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.62(0.25\u0026ndash;1.55)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e0.08(0.01\u0026ndash;0.62)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e\u003cstrong\u003eLocation of incision on the uterus\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eanterior wall\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e33(49.3)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e34(50.7)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\u0026nbsp;\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eposterior wall\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e8(38.1)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e13(61.9)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.58(0.58\u0026ndash;4.29)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e2.70(0.73\u0026ndash;9.95)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eBoth anterior \u0026amp; posterior wall\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e48(60.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e32(40.0)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.64(0.33\u0026ndash;1.94)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e3.09(0.98\u0026ndash;51.04)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003eunspecified\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5(41.7)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"char\" char=\".\"\u003e\n\u003cp\u003e7(58.3)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e1.35(0.39\u0026ndash;4.71)\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd align=\"left\"\u003e\n\u003cp\u003e5.69(0.57\u0026ndash;11.64)\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003ctfoot\u003e\n\u003ctr\u003e\n\u003ctd colspan=\"5\"\u003e*p value\u0026thinsp;\u0026lt;\u0026thinsp;0.05\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tfoot\u003e\n\u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTables 3-5 are not available with this version.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Myomectomy, infertility, pregnancy, myoma, unexplained infertility","lastPublishedDoi":"10.21203/rs.3.rs-250064/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-250064/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eIntroduction:\u003c/strong\u003e Uterine myoma occurs in 20-50% of reproductive age women. Uterine myomas may be associated with 5-10% of cases of infertility, but it is the sole cause or factor in only 2-3% of all infertility cases. Myomectomy is surgery done to remove myoma regardless of the methods.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eObjective\u003c/strong\u003e: to assess impact of myomectomy on pregnancy rate and associated factors among reproductive age women who had myomectomy at St. Paul’s Hospital Millennium Medical College, in Addis Ababa. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethodology\u003c/strong\u003e: Hospital based retrospective cross-sectional study was conducted to determine pregnancy rate after myomectomy \u0026amp; its associated factors. Patients who had myomectomy in SPHMMC from September, 2012 to September, 2017 were enrolled. Information was retrieved from hospital records \u0026amp; phone interviews with the patients. The strength of statistical association was measured by adjusted odds ratios and 95% confidence intervals. Statistical significance was declared at p-value \u0026lt; 0.05. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResult:\u003c/strong\u003e Among 180 females participated in this study, 52.2% got pregnant after myomectomy. The result showed that females with age \u0026gt;35 years were 0.31 times less likely to get pregnant after surgery than those ages 20-25 years [AOR=0.31(95%CI: 0.29-0.54)]. People with no infertility before surgery were 1.19 times more likely to be pregnant after surgery than those with unexplained infertility before the surgery [AOR=1.19(95%CI: 1.06-1.57)]. People with two uterine incisions were 0.06 times less likely [AOR=0.06(95%CI: 0.043-0.51)] while those with three or more than three incisions were 0.02 times less likely [AOR=0.02(95%CI: 0.002-0.22)] to get pregnant compared with those with one incision on uterine wall\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e: Age, number of incision and infertility before surgery were significantly associated with rate of pregnancy after myomectomy.\u003c/p\u003e","manuscriptTitle":"Pregnancy Rate After Myomectomy and Associated Factors Among Reproductive Age Women Who Had Myomectomy at Saint Paul’s Hospital Millennium Medical College, Addis Ababa: Retrospective Cross-sectional Study.","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-03-02 15:01:03","doi":"10.21203/rs.3.rs-250064/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"2787bc15-bcce-45da-99f8-f386ed70050d","owner":[],"postedDate":"March 2nd, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":2706920,"name":"Sexual \u0026 Reproductive Medicine"}],"tags":[],"updatedAt":"2021-11-28T21:54:17+00:00","versionOfRecord":{"articleIdentity":"rs-250064","link":"https://doi.org/10.1155/2021/6680112","journal":{"identity":"international-journal-of-reproductive-medicine","isVorOnly":true,"title":"International Journal of Reproductive Medicine"},"publishedOn":"2021-11-28 21:54:17","publishedOnDateReadable":"November 28th, 2021"},"versionCreatedAt":"2021-03-02 15:01:03","video":"","vorDoi":"10.1155/2021/6680112","vorDoiUrl":"https://doi.org/10.1155/2021/6680112","workflowStages":[]},"version":"v1","identity":"rs-250064","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-250064","identity":"rs-250064","version":["v1"]},"buildId":"_2-kVJe1T_tPrBINL-cwx","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}