Beyond the Secretory Pathway: New Insights into Protein Release

Beyond the Secretory Pathway: New Insights into Protein Release | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL Traffic This is a preprint and has not been peer reviewed. Data may be preliminary. 11 September 2025 V1 Latest version Share on Beyond the Secretory Pathway: New Insights into Protein Release Authors : Ruey-Hwa Chen , Antonio Costa-Filho J , Jayanta Debnath , T Galli 0000-0001-8514-7455 , Liang Ge 0000-0002-7371-2039 , Deborah Goberdhan , Wei Guo , … Show All … , Kangmin He , Ralf Jacob , Tiebang Kang , Min Goo Lee , Lian Li , Fabio Lolicato , Jun Lu , Vivek Malhotra , Walter Nickel , Vassiliki Nikoletopoulou , Stacey K. Ogden , Georgia Maria Sagia 0000-0002-7585-2035 , Feng Shao , Anbing Shi , Clotilde Théry , Christel Vérollet , Julien Villeneuve 0000-0002-5430-1680 , Frederik Verweij 0000-0001-8879-1174 , Yanzhuang Wang , Juan Wang , Shenjie Wu , Yihong Ye 0000-0002-9512-7922 [email protected] , Yin Hang , Li Yu , Min Zhang , Ying Zhang , Xin Zhou 0000-0002-8667-0309 , and Chiara Zurzolo Show Fewer Authors Info & Affiliations https://doi.org/10.22541/au.175760651.18696010/v1 Published Traffic Version of record Peer review timeline 396 views 190 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract In eukaryotes, protein secretion plays essential roles in intercellular communications and extracellular niche-building. Protein secretion generally requires a signal sequence that targets cargos to the canonical secretory pathway consisting of the endoplasmic reticulum (ER), the Golgi apparatus, plasma membrane, and vesicles moving between these compartments. However, cytoplasmic proteins lacking signal sequences (e.g. IL1β, Acb1, FGF2) have been detected and many have defined functions in the extracellular space, suggesting unconventional protein secretion (UcPS) via alternative pathways. In recent years, scientists have uncovered many new UcPS paradigms, reporting a plethora of mechanisms that collectively form a new field. The inaugural Cold Spring Harbor Asia (CSHA) conference on “ Molecular Mechanism and Physiology of Unconventional Secretion” is the first meeting to bring these researchers together, providing a collegial platform for information sharing at this exciting frontier of cell biology research. Supplementary Material File (2025-08-26 csha ucps meeting report clean copy.docx) Download 955.74 KB Information & Authors Information Version history V1 Version 1 11 September 2025 Peer review timeline Published Traffic Version of Record 6 Nov 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Collection Traffic Keyword unconventional protein secretion Authors Affiliations Ruey-Hwa Chen Academia Sinica View all articles by this author Antonio Costa-Filho J University of São Paulo View all articles by this author Jayanta Debnath University of California San Francisco View all articles by this author T Galli 0000-0001-8514-7455 Institute of Psychiatry and Neuroscience of Paris View all articles by this author Liang Ge 0000-0002-7371-2039 Tsinghua University View all articles by this author Deborah Goberdhan University of Oxford View all articles by this author Wei Guo University of Pennsylvania View all articles by this author Kangmin He Institute of Genetics and Developmental Biology Chinese Academy of Sciences View all articles by this author Ralf Jacob Philipps University of Marburg View all articles by this author Tiebang Kang Sun Yat-sen University Cancer Center View all articles by this author Min Goo Lee Yonsei University View all articles by this author Lian Li Emory University School of Medicine View all articles by this author Fabio Lolicato Heidelberg University Biochemistry Center View all articles by this author Jun Lu Yale University View all articles by this author Vivek Malhotra Centre de Regulacio Genomica View all articles by this author Walter Nickel Heidelberg University Biochemistry Center View all articles by this author Vassiliki Nikoletopoulou Universite de Lausanne View all articles by this author Stacey K. Ogden St Jude Children’s Research Hospital View all articles by this author Georgia Maria Sagia 0000-0002-7585-2035 National and Kapodistrian University of Athens View all articles by this author Feng Shao National Institute of Biological Sciences Beijing View all articles by this author Anbing Shi Huazhong University of Science and Technology View all articles by this author Clotilde Théry Institut Curie View all articles by this author Christel Vérollet CNRS-University of Toulouse View all articles by this author Julien Villeneuve 0000-0002-5430-1680 University of Montpellier View all articles by this author Frederik Verweij 0000-0001-8879-1174 University Utrecht View all articles by this author Yanzhuang Wang Shenzhen Bay Laboratory View all articles by this author Juan Wang Beijing University of Technology View all articles by this author Shenjie Wu University of California Berkeley View all articles by this author Yihong Ye 0000-0002-9512-7922 [email protected] National Institutes of Health View all articles by this author Yin Hang Tsinghua University View all articles by this author Li Yu Tsinghua University View all articles by this author Min Zhang Tsinghua University View all articles by this author Ying Zhang Tsinghua University View all articles by this author Xin Zhou 0000-0002-8667-0309 Harbin Medical University View all articles by this author Chiara Zurzolo Institut Pasteur Centre Medical View all articles by this author Metrics & Citations Metrics Article Usage 396 views 190 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Ruey-Hwa Chen, Antonio Costa-Filho J, Jayanta Debnath, et al. Beyond the Secretory Pathway: New Insights into Protein Release. Authorea . 11 September 2025. DOI: https://doi.org/10.22541/au.175760651.18696010/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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