Protective Effect Of Eurycoma Longifolia On Uterine Adhesion Induced By Coitus In Estradiol Valerate Treated Female Rats

Introduction and objective: Adhesion can be defined as fibrous bands of scar-like tissue that appear between two surfaces inside the body. Tissue adhesion formation is one of the common problems in postoperative lower abdomen or uterus in reproductive organs; it can lead to severe complications such as pain and infertility. The objective of this study was to evaluate the effect of standardised extract of Eurycoma longifolia (SEEL) in reducing adhesion formation in the uterus of estradiol valerate (EV)-treated rats induced by coitus. Method: Adult (12-14 weeks-old) female rats with normal Oestrous cycle (OC) were randomly divided into two groups (n = 8 for each group). Each rat (in both groups) was given of EV 2.0 mg/rat. One month after the EV injection, each rat in Group 1 was given SEEL at a dose of 50 mg/kg/d for four weeks. In Group 2, distilled water was orally administered to each rat. After 14 days of SEEL or distilled water treatment, each rat in both groups was allowed to mate with a proven fertile male rat. The duration of the mating was 10-14 days. Results: In the group treated with EV+ SEEL plus mating with a fertile male, the animals looked healthy when compared to the EV+mating group. However, neither implantation nor foetuses were observed during the macroscopical examination in either group. Adhesion on the uterus was not noted in the EV+ SEEL + mating animals. Adhesion formation in the EV+ SEEL+ mating animals was significantly reduced by 12.5% compared with that in the EV+mating group, which had 75%. Conclusion: the present study demonstrates that TAF 273 has been found to show a reduction in adhesion formation.