Crystal Structure and Properties of Thallium(I) Salinomycinate

In this study we present the preparation and characterization of novel thallium(I) coordination compound of the polyether ionophorous antibiotic salinomycin (SalH). The complex [TlSal(H2O)] exists as two subunits SalTl1 and SalTl2 which differ slightly in their structural parameters. Sali-nomycin acts in a pentadentate coordination mode through oxygen donor atoms and the six-fold arrangement around the metal centers is completed by interaction with water molecule. In the overall complex structure, the two mononuclear species SalTl1 and SalTl2 are connected via hy-drogen bond network by third water molecule. The inclusion of the heavy metal ion into the structure of the polyether ionophore reduces its biological activity against Gram-positive microor-ganisms and cervical cancer cells at in vitro conditions.